Introduction
Materials and method
Case selection and manual plan development
KBP modeling
Model clinical validation and verification
Statistical analysis
Results
Dosimetry comparison of the plans of the two groups in the training dataset
Plan added to the IMRT model | Plan added to the VMAT model | P value | |
---|---|---|---|
PTV | |||
Dmax (Gy) | 73.21 ± 0.61 | 72.73 ± 1.29 | 0.051 |
V105% (cc) | 0.11 ± 0.30 | 0.18 ± 0.43 | 0.38 |
HI | 1.06 ± 0.01 | 1.07 ± 0.02 | 0.11 |
CI | 0.89 ± 0.03 | 0.89 ± 0.03 | 0.13 |
Rectum (Gy) | |||
D15% | 52.86 ± 7.47 | 52.53 ± 6.59 | 0.89 |
D25% | 40.13 ± 7.01 | 42.46 ± 7.11 | 0.04 |
D35% | 31.73 ± 7.14 | 35.02 ± 6.65 | 0.01 |
D50% | 21.10 ± 6.75 | 15.97 ± 15.5 | 0.04 |
Bladder(Gy) | |||
D15% | 35.30 ± 17.24 | 36.32 ± 18.84 | 0.22 |
D25% | 25.09 ± 17.44 | 25.19 ± 19.99 | 0.91 |
D35% | 20.32 ± 16.1 | 20.23 ± 18.11 | 0.93 |
D50% | 14.90 ± 12.85 | 15.97 ± 15.5 | 0.26 |
Lt femur (Gy) | |||
Dmax | 29.25 ± 7.10 | 36.05 ± 6.73 | 3.27 |
D40% | 14.41 ± 4.29 | 14.38 ± 7.60 | 0.98 |
D25% | 17.12 ± 5.18 | 19.56 ± 8.54 | 0.09 |
Rt femur (Gy) | |||
Dmax | 29.15 ± 7.05 | 34.83 ± 6.95 | 0.00 |
D40% | 15.65 ± 4.47 | 14.96 ± 7.09 | 0.57 |
D25% | 18.87 ± 5.99 | 19.87 ± 7.83 | 0.49 |
Outlier management and statistical validation results
Dosimetric comparison of the target region and OAR in the validation dataset
M-IMRT(M) | V-IMRT(V) | I-IMRT(I) | P value | |||
---|---|---|---|---|---|---|
M&V | V&I | M&I | ||||
PTV | ||||||
Dmax (Gy) | 73.95 ± 1.04 | 73.22 ± 0.87 | 72.90 ± 0.59 | 0.54 | 0.65 | 0.89 |
V105% (cc) | 0.12 ± 0.25 | 0.01 ± 0.01 | 0.00 ± 0.01 | 0.17 | 0.21 | 0.88 |
HI | 1.05 ± 0.02 | 1.04 ± 0.01 | 1.04 ± 0.01 | 0.12 | 0.04 | 0.57 |
CI | 0.87 ± 0.03 | 0.89 ± 0.01 | 0.86 ± 0.02 | 0.64 | 0.61 | 0.58 |
Rectum(Gy) | ||||||
D15% | 51.68 ± 2.69 | 52.98 ± 5.53 | 52.51 ± 5.31 | 0.25 | 0.51 | 0.65 |
D25% | 41.85 ± 2.57 | 42.85 ± 6.19 | 41.92 ± 6.37 | 0.60 | 0.97 | 0.46 |
D35% | 34.88 ± 2.12 | 34.84 ± 5.94 | 33.69 ± 7.10 | 0.99 | 0.65 | 0.48 |
D50% | 25.63 ± 2.77 | 23.45 ± 5.67 | 23.92 ± 7.36 | 0.35 | 0.55 | 0.66 |
Bladder(Gy) | ||||||
D15% | 45.36 ± 13.85 | 38.84 ± 17.74 | 39.85 ± 17.55 | 0.20 | 0.28 | 0.06 |
D25% | 37.27 ± 17.54 | 25.88 ± 18.45 | 26.54 ± 18.45 | 0.05 | 0.07 | 0.01 |
D35% | 32.01 ± 16.33 | 17.69 ± 16.36 | 17.77 ± 16.36 | 0.01 | 0.01 | 0.88 |
D50% | 25.94 ± 15.49 | 10.54 ± 12.42 | 10.36 ± 12.58 | 0.01 | 0.01 | 0.67 |
Left femoral head(Gy) | ||||||
Dmax | 40.24 ± 6.90 | 35.28 ± 7.48 | 35.13 ± 6.65 | 0.02 | 0.01 | 0.88 |
D40% | 20.17 ± 8.28 | 15.99 ± 7.36 | 16.44 ± 7.53 | 0.01 | 0.01 | 0.04 |
D25% | 24.22 ± 9.14 | 19.25 ± 8.37 | 19.59 ± 8.23 | 0.01 | 0.01 | 0.35 |
Right femoral head(Gy) | ||||||
Dmax | 37.92 ± 11.57 | 28.74 ± 11.57 | 31 ± 9.72 | 0.00 | 0.01 | 0.04 |
D40% | 19.68 ± 8.72 | 12.67 ± 7.2 | 13.42 ± 6.87 | 0.00 | 0.01 | 0.24 |
D25% | 24.11 ± 9.12 | 16.71 ± 8.13 | 17.6 ± 8.11 | 0.00 | 0.01 | 0.20 |
Discussion
Item | V-IMRT | I-IMRT | P value |
---|---|---|---|
RV | |||
Dmean (Gy) | 2.94 ± 1.51 | 3.07 ± 1.65 | 0.02 |
V5Gy (cc) | 3974.44 ± 1114.31 | 3902 ± 1085.85 | 0.11 |
MU | 860.4 ± 139.26 | 860.9 ± 163.97 | 0.98 |