nach oben

European Journal of Nutrition

Erschienen in:

21.09.2023 | Original Contribution

The association of preconceptional folic acid supplementation with gestational age and preterm birth risk in twin pregnancies: a prospective cohort study in China

verfasst von: Yuanqing Xia, Lili Huang, Zichong Long, Yiting Chen, Li Gao, Renyi Hua, Shenghui Li, Yanlin Wang

Erschienen in: European Journal of Nutrition | Ausgabe 1/2024

Einloggen, um Zugang zu erhalten

Abstract

Purpose

This study aims to explore the association of maternal preconceptional folic acid (FA) supplementation with gestational age and preterm birth in twin pregnancies, and whether the association varies by chorionicity or conception mode.

Methods

From November 2018 to December 2021, the information of FA supplementation and pregnancy outcomes were collected in twin pregnant women. The linear regression models and the logistic regression were used to test the association of preconceptional FA supplementation with gestational age at delivery and preterm birth and premature rupture of membranes (PROM).

Results

A total of 416 twin pregnancies were included. Compared with no use in twins, maternal preconceptional FA use was associated with a 0.385-week longer gestational age (95% CI 0.019–0.751) and lower risk of preterm birth < 36 weeks (adjusted OR 0.519; 95% CI 0.301–0.895) and PROM (adjusted OR 0.426; 95% CI 0.215–0.845). The protective effect on preterm birth < 36 weeks and PROM is similar whether taking FA supplements alone or multivitamins. However, the associations varied by chorionicity and conception mode of twins or compliance with supplementation. The positive associations between preconceptional FA use and gestational age only remained significant among twins via assisted reproductive technology or dichorionic diamniotic twins. Significant protective effects on preterm birth < 36 weeks and PROM were only found among women who took FA at least 4 times a week before conception.

Conclusion

Maternal preconceptional FA supplementation was associated with longer gestation duration and lower risk of preterm birth < 36 weeks and PROM in twin pregnancies. To improve the success of their pregnancies, reproductive women should start taking FA supplements well before conception and with good compliance.

Nur mit Berechtigung zugänglich

Smits J, Monden C (2011) Twinning across the developing world. PLoS ONE 6(9):e25239. https://doi.org/10.1371/journal.pone.0025239CrossRefPubMedPubMedCentral

Ananth CV, Chauhan SP (2012) Epidemiology of twinning in developed countries. Semin Perinatol 36(3):156–161. https://doi.org/10.1053/j.semperi.2012.02.001CrossRefPubMed

Monden C, Pison G, Smits J (2021) Twin peaks: more twinning in humans than ever before. Hum Reprod (Oxford, England) 36(6):1666–1673. https://doi.org/10.1093/humrep/deab029CrossRef

Deng C, Dai L, Yi L, Li X, Deng K, Mu Y, Wang K, Tao J, Li Q, Xu L (2019) Temporal trends in the birth rates and perinatal mortality of twins: a population-based study in China. PLoS ONE 14(1):e0209962. https://doi.org/10.1371/journal.pone.0209962CrossRefPubMedPubMedCentral

Stock S, Norman J (2010) Preterm and term labour in multiple pregnancies. Semin Fetal Neonatal Med 15(6):336–341. https://doi.org/10.1016/j.siny.2010.06.006CrossRefPubMed

Dodd JM, Grivell RM, Obrien CM, Dowswell T, Deussen AR (2017) Prenatal administration of progestogens for preventing spontaneous preterm birth in women with a multiple pregnancy. Cochrane Database Syst Rev 10(10):Cd012024. https://doi.org/10.1002/14651858.CD012024.pub2CrossRefPubMed

Blencowe H, Cousens S, Oestergaard MZ, Chou D, Moller AB, Narwal R, Adler A, Vera Garcia C, Rohde S, Say L, Lawn JE (2012) National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications. Lancet (London, England) 379(9832):2162–2172. https://doi.org/10.1016/s0140-6736(12)60820-4CrossRefPubMed

Liu L, Oza S, Hogan D, Chu Y, Perin J, Zhu J, Lawn JE, Cousens S, Mathers C, Black RE (2016) Global, regional, and national causes of under-5 mortality in 2000–15: an updated systematic analysis with implications for the Sustainable Development Goals. Lancet (London, England) 388(10063):3027–3035. https://doi.org/10.1016/s0140-6736(16)31593-8CrossRefPubMed

Vogel JP, Chawanpaiboon S, Moller AB, Watananirun K, Bonet M, Lumbiganon P (2018) The global epidemiology of preterm birth. Best Pract Res Clin Obstet Gynaecol 52:3–12. https://doi.org/10.1016/j.bpobgyn.2018.04.003CrossRefPubMed

10.

Mwaniki MK, Atieno M, Lawn JE, Newton CR (2012) Long-term neurodevelopmental outcomes after intrauterine and neonatal insults: a systematic review. Lancet (London, England) 379(9814):445–452. https://doi.org/10.1016/s0140-6736(11)61577-8CrossRefPubMed

11.

Araújo BF, Zatti H, Madi JM, Coelho MB, Olmi FB, Canabarro CT (2012) Analysis of neonatal morbidity and mortality in late-preterm newborn infants. J Pediatr 88(3):259–266. https://doi.org/10.2223/jped.2196CrossRef

12.

Saigal S, Doyle LW (2008) An overview of mortality and sequelae of preterm birth from infancy to adulthood. Lancet (London, England) 371(9608):261–269. https://doi.org/10.1016/s0140-6736(08)60136-1CrossRefPubMed

13.

Crider KS, Yang TP, Berry RJ, Bailey LB (2012) Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate’s role. Adv Nutr (Bethesda, Md) 3(1):21–38. https://doi.org/10.3945/an.111.000992CrossRef

14.

De-Regil LM, Peña-Rosas JP, Fernández-Gaxiola AC, Rayco-Solon P (2015) Effects and safety of periconceptional oral folate supplementation for preventing birth defects. Cochrane Database Syst Rev 2015(12):Cd007950. https://doi.org/10.1002/14651858.CD007950.pub3CrossRefPubMedPubMedCentral

15.

Daly S, Mills JL, Molloy AM, Conley M, Lee YJ, Kirke PN, Weir DG, Scott JM (1997) Minimum effective dose of folic acid for food fortification to prevent neural-tube defects. Lancet (London, England) 350(9092):1666–1669. https://doi.org/10.1016/s0140-6736(97)07247-4CrossRefPubMed

16.

Czeizel AE, Dudás I (1992) Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med 327(26):1832–1835. https://doi.org/10.1056/nejm199212243272602CrossRefPubMed

17.

Smithells RW, Sheppard S, Schorah CJ, Seller MJ, Nevin NC, Harris R, Read AP, Fielding DW (1980) Possible prevention of neural-tube defects by periconceptional vitamin supplementation. Lancet (London, England) 1(8164):339–340. https://doi.org/10.1016/s0140-6736(80)90886-7CrossRefPubMed

18.

Wu Y, Yuan Y, Kong C, Ma Q, Ye H, Jing W, Liu J, Liu M (2021) The association between periconceptional folic acid supplementation and the risk of preterm birth: a population-based retrospective cohort study of 200,000 women in China. Eur J Nutr 60(4):2181–2192. https://doi.org/10.1007/s00394-020-02409-8CrossRefPubMed

19.

Li Q, Wang YY, Guo Y, Zhou H, Wang X, Wang QM, Shen HP, Zhang YP, Yan DH, Li S, Chen G, Lin L, He Y, Yang Y, Peng ZQ, Wang HJ, Ma X (2020) Folic acid supplementation and the association between maternal airborne particulate matter exposure and preterm delivery: a national birth cohort study in China. Environ Health Perspect 128(12):127010. https://doi.org/10.1289/ehp6386CrossRefPubMedPubMedCentral

20.

Li Z, Ye R, Zhang L, Li H, Liu J, Ren A (2014) Periconceptional folic acid supplementation and the risk of preterm births in China: a large prospective cohort study. Int J Epidemiol 43(4):1132–1139. https://doi.org/10.1093/ije/dyu020CrossRefPubMedPubMedCentral

21.

Liu X, Lv L, Zhang H, Zhao N, Qiu J, He X, Zhou M, Xu X, Cui H, Liu S, Lerro C, Lin X, Zhang C, Zhang H, Xu R, Zhu D, Dang Y, Han X, Bai H, Chen Y, Tang Z, Lin R, Yao T, Su J, Wang W, Wang Y, Ma B, Huang H, Liang J, Qiu W, Liu Q, Zhang Y (2016) Folic acid supplementation, dietary folate intake and risk of preterm birth in China. Eur J Nutr 55(4):1411–1422. https://doi.org/10.1007/s00394-015-0959-1CrossRefPubMed

22.

Bukowski R, Malone FD, Porter FT, Nyberg DA, Comstock CH, Hankins GD, Eddleman K, Gross SJ, Dugoff L, Craigo SD, Timor-Tritsch IE, Carr SR, Wolfe HM, D’Alton ME (2009) Preconceptional folate supplementation and the risk of spontaneous preterm birth: a cohort study. PLoS Med 6(5):e1000061. https://doi.org/10.1371/journal.pmed.1000061CrossRefPubMedPubMedCentral

23.

Zheng JS, Guan Y, Zhao Y, Zhao W, Tang X, Chen H, Xu M, Wu L, Zhu S, Liu H, Huang T, Li D (2016) Pre-conceptional intake of folic acid supplements is inversely associated with risk of preterm birth and small-for-gestational-age birth: a prospective cohort study. Br J Nutr 115(3):509–516. https://doi.org/10.1017/s0007114515004663CrossRefPubMed

24.

Wang Y, Cao Z, Peng Z, Xin X, Zhang Y, Yang Y, He Y, Xu J, Ma X (2015) Folic acid supplementation, preconception body mass index, and preterm delivery: findings from the preconception cohort data in a Chinese rural population. BMC Preg Childb 15:336. https://doi.org/10.1186/s12884-015-0766-yCrossRef

25.

Catov JM, Bodnar LM, Olsen J, Olsen S, Nohr EA (2011) Periconceptional multivitamin use and risk of preterm or small-for-gestational-age births in the Danish National Birth Cohort. Am J Clin Nutr 94(3):906–912. https://doi.org/10.3945/ajcn.111.012393CrossRefPubMedPubMedCentral

26.

Chen LW, Lim AL, Colega M, Tint MT, Aris IM, Tan CS, Chong YS, Gluckman PD, Godfrey KM, Kwek K, Saw SM, Yap F, Lee YS, Chong MF, van Dam RM (2015) Maternal folate status, but not that of vitamins B-12 or B-6, is associated with gestational age and preterm birth risk in a multiethnic Asian population. J Nutr 145(1):113–120. https://doi.org/10.3945/jn.114.196352CrossRefPubMed

27.

Parazzini F, Chiaffarino F, Ricci E, Improta L, Monni G (2011) Homocysteine, red cell, and plasma folate concentrations and birth weight in Italian women: results from a prospective study. J Maternal Fetal Neonatal Med 24(3):427–431. https://doi.org/10.3109/14767058.2010.501127CrossRef

28.

Leduc L, Takser L, Rinfret D (2005) Persistance of adverse obstetric and neonatal outcomes in monochorionic twins after exclusion of disorders unique to monochorionic placentation. Am J Obstet Gynecol 193(5):1670–1675. https://doi.org/10.1016/j.ajog.2005.04.007CrossRefPubMed

29.

Koudstaal J, Bruinse HW, Helmerhorst FM, Vermeiden JP, Willemsen WN, Visser GH (2000) Obstetric outcome of twin pregnancies after in-vitro fertilization: a matched control study in four Dutch university hospitals. Hum Reprod (Oxford, England) 15(4):935–940. https://doi.org/10.1093/humrep/15.4.935CrossRef

30.

Breathnach FM, McAuliffe FM, Geary M, Daly S, Higgins JR, Dornan J, Morrison JJ, Burke G, Higgins S, Dicker P, Manning F, Carroll S, Malone FD (2012) Optimum timing for planned delivery of uncomplicated monochorionic and dichorionic twin pregnancies. Obstet Gynecol 119(1):50–59. https://doi.org/10.1097/AOG.0b013e31823d7b06CrossRefPubMed

31.

Visintin C, Mugglestone MA, James D, Kilby MD (2011) Antenatal care for twin and triplet pregnancies: summary of NICE guidance. BMJ (Clinical research ed) 343:d5714. https://doi.org/10.1136/bmj.d5714CrossRefPubMed

32.

Chow S-C, Shao J, Wang H (2008) Sample size calculations in clinical research, 2nd edn. Chapman & Hall/CRC, New York

33.

Shieh G (2019) Effect size, statistical power, and sample size for assessing interactions between categorical and continuous variables. Br J Math Stat Psychol 72(1):136–154. https://doi.org/10.1111/bmsp.12147CrossRefPubMed

34.

Martín-Calvo N, Mínguez-Alarcón L, Gaskins AJ, Nassan FL, Williams PL, Souter I, Hauser R, Chavarro JE (2019) Paternal preconception folate intake in relation to gestational age at delivery and birthweight of newborns conceived through assisted reproduction. Reprod Biomed Online 39(5):835–843. https://doi.org/10.1016/j.rbmo.2019.07.005CrossRefPubMedPubMedCentral

35.

Timmermans S, Jaddoe VW, Hofman A, Steegers-Theunissen RP, Steegers EA (2009) Periconception folic acid supplementation, fetal growth and the risks of low birth weight and preterm birth: the Generation R Study. Br J Nutr 102(5):777–785. https://doi.org/10.1017/s0007114509288994CrossRefPubMed

36.

Shaw GM, Carmichael SL, Yang W, Siega-Riz AM (2011) Periconceptional intake of folic acid and food folate and risks of preterm delivery. Am J Perinatol 28(10):747–752. https://doi.org/10.1055/s-0031-1280855CrossRefPubMed

37.

Victoria MA (2006) Pregnancy outcomes after assisted reproductive technology. J Obstetr Gynaecol Canada JOGC J d’obstetriq Gynecol Can JOGC 3(28):220–233

38.

Lb Y (2010) Epigenetics, genomic imprinting and assisted reproductive technology. Ann Endocrinol 3(71):237–238

39.

Florjanski J, Zimmer M, Borowiec Z, Pomorski M, Filipowski H (2010) Complication rates in the second and third trimester of spontaneous twin pregnancies and twin pregnancies after in vitro fertilization. Neuro Endocrinol Lett 31(3):384–389PubMed

40.

Qin JB, Wang H, Sheng X, Xie Q, Gao S (2016) Assisted reproductive technology and risk of adverse obstetric outcomes in dichorionic twin pregnancies: a systematic review and meta-analysis. Fertil Steril 105(5):1180–1192. https://doi.org/10.1016/j.fertnstert.2015.12.131CrossRefPubMed

41.

Stephenson J, Heslehurst N, Hall J, Schoenaker D, Hutchinson J, Cade JE, Poston L, Barrett G, Crozier SR, Barker M, Kumaran K, Yajnik CS, Baird J, Mishra GD (2018) Before the beginning: nutrition and lifestyle in the preconception period and its importance for future health. Lancet (London, England) 391(10132):1830–1841. https://doi.org/10.1016/s0140-6736(18)30311-8CrossRefPubMed

42.

Barker M, Dombrowski SU, Colbourn T, Fall CHD, Kriznik NM, Lawrence WT, Norris SA, Ngaiza G, Patel D, Skordis-Worrall J, Sniehotta FF, Steegers-Theunissen R, Vogel C, Woods-Townsend K, Stephenson J (2018) Intervention strategies to improve nutrition and health behaviours before conception. Lancet (London, England) 391(10132):1853–1864. https://doi.org/10.1016/s0140-6736(18)30313-1CrossRefPubMed

43.

Siega-Riz AM, Savitz DA, Zeisel SH, Thorp JM, Herring A (2004) Second trimester folate status and preterm birth. Am J Obstet Gynecol 191(6):1851–1857. https://doi.org/10.1016/j.ajog.2004.07.076CrossRefPubMed

44.

Selhub J, Jacques PF, Wilson PW, Rush D, Rosenberg IH (1993) Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 270(22):2693–2698. https://doi.org/10.1001/jama.1993.03510220049033CrossRefPubMed

45.

van der Molen EF, Verbruggen B, Nováková I, Eskes TK, Monnens LA, Blom HJ (2000) Hyperhomocysteinemia and other thrombotic risk factors in women with placental vasculopathy. BJOG 107(6):785–791. https://doi.org/10.1111/j.1471-0528.2000.tb13341.xCrossRefPubMed

46.

Goldenberg RL, Hauth JC, Andrews WW (2000) Intrauterine infection and preterm delivery. N Engl J Med 342(20):1500–1507. https://doi.org/10.1056/nejm200005183422007CrossRefPubMed

47.

Goldenberg RL, Culhane JF, Iams JD, Romero R (2008) Epidemiology and causes of preterm birth. Lancet (London, England) 371(9606):75–84. https://doi.org/10.1016/s0140-6736(08)60074-4CrossRefPubMed

48.

Kim H, Hwang JY, Ha EH, Park H, Ha M, Lee SJ, Hong YC, Chang N (2011) Association of maternal folate nutrition and serum C-reactive protein concentrations with gestational age at delivery. Eur J Clin Nutr 65(3):350–356. https://doi.org/10.1038/ejcn.2010.267CrossRefPubMed

49.

Zhao M, Chen YH, Dong XT, Zhou J, Chen X, Wang H, Wu SX, Xia MZ, Zhang C, Xu DX (2013) Folic acid protects against lipopolysaccharide-induced preterm delivery and intrauterine growth restriction through its anti-inflammatory effect in mice. PLoS ONE 8(12):e82713. https://doi.org/10.1371/journal.pone.0082713CrossRefPubMedPubMedCentral

50.

Bruinse HW, van den Berg H (1995) Changes of some vitamin levels during and after normal pregnancy. Eur J Obstet Gynecol Reprod Biol 61(1):31–37. https://doi.org/10.1016/0028-2243(95)02150-qCrossRefPubMed

51.

Nijhout HF, Reed MC, Budu P, Ulrich CM (2004) A mathematical model of the folate cycle: new insights into folate homeostasis. J Biol Chem 279(53):55008–55016. https://doi.org/10.1074/jbc.M410818200CrossRefPubMed

52.

Wald NJ, Law MR, Morris JK, Wald DS (2001) Quantifying the effect of folic acid. Lancet (London, England) 358(9298):2069–2073. https://doi.org/10.1016/s0140-6736(01)07104-5CrossRefPubMed

53.

Fuchs F, Senat MV (2016) Multiple gestations and preterm birth. Semin Fetal Neonatal Med 21(2):113–120. https://doi.org/10.1016/j.siny.2015.12.010CrossRefPubMed

54.

Kugelman A, Colin AA (2013) Late preterm infants: near term but still in a critical developmental time period. Pediatrics 132(4):741–751. https://doi.org/10.1542/peds.2013-1131CrossRefPubMed

55.

Institute of Medicine Committee on Understanding Premature B, Assuring Healthy O (2007) The National Academies Collection: reports funded by National Institutes of Health. In: Behrman RE, Butler AS (eds) Preterm birth: causes, consequences, and prevention. National Academies Press (US), Washington DC. https://doi.org/10.17226/11622CrossRef

56.

Seale AC (2016) Every day and every gram counts at birth. Lancet Infect Dis 16(8):876–877. https://doi.org/10.1016/s1473-3099(16)00154-7CrossRefPubMed

57.

Miller JE, Hammond GC, Strunk T, Moore HC, Leonard H, Carter KW, Bhutta Z, Stanley F, de Klerk N, Burgner DP (2016) Association of gestational age and growth measures at birth with infection-related admissions to hospital throughout childhood: a population-based, data-linkage study from Western Australia. Lancet Infect Dis 16(8):952–961. https://doi.org/10.1016/s1473-3099(16)00150-xCrossRefPubMed

58.

Yoshida-Montezuma Y, Sivapathasundaram B, Brown HK, Keown-Stoneman C, de Souza RJ, To T, Borkhoff CM, Birken CS, Maguire JL, Anderson LN (2022) Association of late preterm birth and size for gestational age with cardiometabolic risk in childhood. JAMA Netw Open 5(5):e2214379. https://doi.org/10.1001/jamanetworkopen.2022.14379CrossRefPubMedPubMedCentral

59.

Ren A, Zhang L, Li Z, Hao L, Tian Y, Li Z (2006) Awareness and use of folic acid, and blood folate concentrations among pregnant women in northern China—an area with a high prevalence of neural tube defects. Reprod Toxicol (Elmsford, NY) 22(3):431–436. https://doi.org/10.1016/j.reprotox.2006.02.003CrossRef

60.

Zhao Y, Hao L, Zhang L, Tian Y, Cao Y, Xia H, Deng Y, Wang T, Yu M, Li Z (2009) Plasma folate status and dietary folate intake among Chinese women of childbearing age. Matern Child Nutr 5(2):104–116. https://doi.org/10.1111/j.1740-8709.2008.00172.xCrossRefPubMedPubMedCentral

61.

Liu J, Jin L, Meng Q, Gao L, Zhang L, Li Z, Ren A (2015) Changes in folic acid supplementation behaviour among women of reproductive age after the implementation of a massive supplementation programme in China. Public Health Nutr 18(4):582–588. https://doi.org/10.1017/s1368980014000950CrossRefPubMed

62.

Zeng Z, Zhu J (2010) Low folic acid supplement intake rate among women in northern China with a high-prevalence of neural tube defects, 2008. Prev Med 51(3–4):338–339. https://doi.org/10.1016/j.ypmed.2010.07.015CrossRefPubMed

63.

Paulik E, Császár J, Kozinszky Z, Nagymajtényi L (2009) Preconceptional and prenatal predictors of folic acid intake in Hungarian pregnant women. Eur J Obstet Gynecol Reprod Biol 145(1):49–52. https://doi.org/10.1016/j.ejogrb.2009.03.020CrossRefPubMed

64.

Bärebring L, Mullally D, Glantz A, Elllis J, Hulthén L, Jagner Å, Bullarbo M, Winkvist A, Augustin H (2018) Sociodemographic factors associated with dietary supplement use in early pregnancy in a Swedish cohort. Br J Nutr 119(1):90–95. https://doi.org/10.1017/s0007114517003270CrossRefPubMed

Titel: The association of preconceptional folic acid supplementation with gestational age and preterm birth risk in twin pregnancies: a prospective cohort study in China
verfasst von: Yuanqing Xia
Lili Huang
Zichong Long
Yiting Chen
Li Gao
Renyi Hua
Shenghui Li
Yanlin Wang
Publikationsdatum: 21.09.2023
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 1/2024
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-023-03223-8

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Alphablocker schützt vor Miktionsproblemen nach der Biopsie

16.05.2024 alpha-1-Rezeptorantagonisten Nachrichten

Nach einer Prostatabiopsie treten häufig Probleme beim Wasserlassen auf. Ob sich das durch den periinterventionellen Einsatz von Alphablockern verhindern lässt, haben australische Mediziner im Zuge einer Metaanalyse untersucht.

Eingreifen von Umstehenden rettet vor Erstickungstod!

15.05.2024 Fremdkörperaspiration Nachrichten

Wer sich an einem Essensrest verschluckt und um Luft ringt, benötigt vor allem rasche Hilfe. Dass Umstehende nur in jedem zweiten Erstickungsnotfall bereit waren, diese zu leisten, ist das ernüchternde Ergebnis einer Beobachtungsstudie aus Japan. Doch es gibt auch eine gute Nachricht.

Neue S3-Leitlinie zur unkomplizierten Zystitis: Auf Antibiotika verzichten?

15.05.2024 Harnwegsinfektionen Nachrichten

Welche Antibiotika darf man bei unkomplizierter Zystitis verwenden und wovon sollte man die Finger lassen? Welche pflanzlichen Präparate können helfen? Was taugt der zugelassene Impfstoff? Antworten vom Koordinator der frisch überarbeiteten S3-Leitlinie, Prof. Florian Wagenlehner.

Schadet Ärger den Gefäßen?

14.05.2024 Arteriosklerose Nachrichten

In einer Studie aus New York wirkte sich Ärger kurzfristig deutlich negativ auf die Endothelfunktion gesunder Probanden aus. Möglicherweise hat dies Einfluss auf die kardiovaskuläre Gesundheit.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 1/2024

Cardiovascular health: balancing salt and water consumption

Protein intake and type 2 diabetes mellitus: an umbrella review of systematic reviews for the evidence-based guideline for protein intake of the German Nutrition Society

Substitution analyses of foods with varying fat quality and the associations with all-cause mortality and impact of the FADS-1 genotype in elderly men

Correction to: Buttermilk: an important source of lipid soluble forms of choline that influences the immune system development in Sprague–Dawley rat offspring

Validity of combined hydration self-assessment measurements to estimate a low vs. high urine concentration in a small sample of (tactical) athletes