Erschienen in:
01.07.2011 | Editorial
The brain–lung–brain axis
verfasst von:
Robert D. Stevens, Louis Puybasset
Erschienen in:
Intensive Care Medicine
|
Ausgabe 7/2011
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Excerpt
Severe neurological dysfunction and injury are associated with a propensity to develop concurrent pulmonary edema and lung injury which can further worsen clinical outcomes [
1]. This has been observed in a range of settings including traumatic brain injury [
2], aneurysmal subarachnoid hemorrhage [
3], status epilepticus [
4], and in brain death [
5]. More recently, studies have shown that critical pulmonary disorders such as acute lung injury and acute respiratory distress syndrome (ALI/ARDS) may be responsible for brain injury and poor neurocognitive outcomes [
6,
7]. While the implications of these findings are considerable, the underlying biological mechanisms need clarification. …