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Graefe's Archive for Clinical and Experimental Ophthalmology

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01.02.2012 | Retinal Disorders

The characterization of functional disturbances in Chinese patients with Bietti’s crystalline dystrophy at different fundus stages

verfasst von: Dan Ning Liu, Yong Liu, Xiao Hong Meng, Zheng Qin Yin

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 2/2012

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Abstract

Purpose

The aim of this study was to characterize the functional and clinical disturbances and screen the optimal functional tests in assessing Bietti’s crystalline dystrophy (BCD) patients by a cross-sectional method.

Methods

The clinical characteristics of BCD were studied in 15 Chinese patients using fundoscopy, fundus fluorescein angiography (FFA), and autofluorescence (AF). The functional features were evaluated by full-field electroretinography (fERG), 85º and 30º perimetry, multifocal ERG (mERG), and chromatic pupillometry.

Results

The 15 patients were separated into three clinical stages according to their fundus features. fERG- and mERG- showed reduced reponses in the early stages. Substages could be further defined according to the fERG results in the intermediate stages. Reduced pupillary light reflex (PLR) activities with blue-and white-light stumili existed in all patients. The most reduced PLR activities were elicited in the advanced stage of patients who had other nonresponsive functional tests.

Conclusions

This study identified the most sensitive functional methods for assessing BCD patients, and the significance of PLR in the advanced stages. In addition, the defined-substages can help us understand the disease more clearly.

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Titel: The characterization of functional disturbances in Chinese patients with Bietti’s crystalline dystrophy at different fundus stages
verfasst von: Dan Ning Liu
Yong Liu
Xiao Hong Meng
Zheng Qin Yin
Publikationsdatum: 01.02.2012
Verlag: Springer-Verlag
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 2/2012
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-011-1809-3

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