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Supportive Care in Cancer

Erschienen in:

01.03.2009 | Original Article

The Efficacy of prophylactic Shakuyaku-Kanzo-to for myalgia and arthralgia following Carboplatin and Paclitaxel combination chemotherapy for non-small cell lung cancer

verfasst von: Tsutomu Yoshida, Toshiyuki Sawa, Takashi Ishiguro, Akane Horiba, Shinya Minatoguchi, Hisayoshi Fujiwara

Erschienen in: Supportive Care in Cancer | Ausgabe 3/2009

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Abstract

Introduction

To assess the efficacy of Shakuyaku-Kanzo-to, a Japanese herbal medicine, for prophylaxis against paclitaxel-induced myalgia and arthralgia, a comparative study was conducted with 50 patients treated with carboplatin and paclitaxel.

Patients and Methods

Patients were alternatively assigned to receive either the intervention group (with Shakuyaku-Kanzo-to) or the control group (without Shakuyaku-Kanzo-to). We assessed the grade and the duration of myalgia and arthralgia.

Results

The grades of myalgia and arthralgia in the control group were significantly higher than the grades determined in the intervention group (p = 0.018). The mean duration of myalgia and arthralgia was 2.78 ± 2.09 days for the intervention group and 5.08 ± 2.89 days for the control group. The duration was significantly shorter in the intervention group than in the control group (p = 0.002).

Discussion

This study shows that prophylactic administration of Shakuyaku-Kanzo-to was effective against paclitaxel-induced myalgia and arthralgia.

Boyle FM, Monk R, Davey R et al (1996) Prevention of experimental paclitaxel neuropathy with glutamate. Proc AACR 37(Abstr #1974):290

Brystol-Myers Squibb (1996) Taxol (paclitaxel) injection prescribing information. Brystol-Myers Squibb, Princeton, pp 1–6

Fujii K, Okamoto S, Saitoh K, Sasaki N, Takano M, Tanaka S (2004) The efficacy of Shakuyaku-Kanzo-to for peripheral nerve dysfunction in paclitaxel combination chemotherapy for epithelial ovarian carcinoma. Gan To Kagaku Ryoho 31(10):1537–1540PubMed

Hotta K, Matsuo K, Ueoka H, Kiura K, Tabata M, Tanimoto M et al (2004) Meta-analysis of randomized clinical trials comparing cisplatin to carboplatin in patients with advanced non-small-cell lung cancer. JCO 2004:3852–3859CrossRef

Moriyama T, Higashi T, Yogashi K, Iida T, Segi E, Sugimoto Y et al (2005) Sensitization of TRPV1 by EP1 and IP reveals peripheral nociceptive mechanism of prostaglandins. Mol Pain 1(1):3. doi:10.1186/1744-8069-1-3 PubMedCrossRef

Murata T, Ushikabi F, Matsuoka T, Hirata M, Yamasaki A, Sugimoto Y et al (1997) Alterd pain perception and inflammatory response in mice lacking prostacyclin receptor. Nature 388:678–682. doi:10.1038/41780 PubMedCrossRef

Non-small Cell Lung Cancer Collaborative Group (1995) Chemotherapy in non-small cell lung cancer: A meta-analysis using updated data on individual patients from 52 randomized clinical trials. BMJ 311:899–909

Oho Y, Ohashi Y, Kubota K et al (2007) Randomized phase III study of cisplatin plus irinotecan versus carboplatin plus paclitaxel, cisplatin plus gemcitabine, and cisplatin plus vinorelbine for advanced non-small cell lung cancer: Four-Arm Cooperative Study in Japan. Ann Oncol 18(2):317–323. doi:10.1093/annonc/mdl377 CrossRef

Ohuchi K, Kamada Y, Levine L, Tsurufuji S (1981) Glycyrrhizin inhibits prostaglandin E2 production by activated peritoneal macrophages from rats. Prostaglandins Med 7(5):457–463. doi:10.1016/0161-4630(81)90033-1 PubMedCrossRef

10.

Rowinsky EK, Donehower RC, Jones RJ, Tucker RW (1988) Microtubule changes and cytotoxicity in leukemic cell line treated with Taxol. Cancer Res 48:4093–4100PubMed

11.

Samad TA, Sapirstein A, Woolf CJ (2002) Prostanoids and pain: unraveling mechanisms and revealing therapeutic targets. Trends Mol Med 8:390–396. doi:10.1016/S1471-4914(02)02383-3 PubMedCrossRef

12.

Schiff PB, Horwitz SB (1981) Taxol assembles tubulin in the absence of exogenous guanosine 5’-triphosphate or microtubule-associated proteins. Biochemistry 20:3247–3252. doi:10.1021/bi00514a041 PubMedCrossRef

13.

Shiki Y, Ishihara Y, Shirai K, Saito Y, Yoshida S (1986) Effect of glycyrrhizin on lysosomes labilization by phospholipase A2. Am J Chin Med 14:131–137. doi:10.1142/S0192415X86000211 PubMedCrossRef

14.

Van Deventer H, Bernard S (1999) Use of gabapentin to treat taxan-induced myalgia. J Clin Oncol 17(1):434–435PubMed

15.

Yana T, Takada M, Origasa H, Ijima T, Yamamoto N, Nakagawa K (2002) New chemotherapy agent plus platinum for advanced non-small cell lung cancer: a meta-analysis. Proc Am Soc Clin Oncol 21:328a

Titel: The Efficacy of prophylactic Shakuyaku-Kanzo-to for myalgia and arthralgia following Carboplatin and Paclitaxel combination chemotherapy for non-small cell lung cancer
verfasst von: Tsutomu Yoshida
Toshiyuki Sawa
Takashi Ishiguro
Akane Horiba
Shinya Minatoguchi
Hisayoshi Fujiwara
Publikationsdatum: 01.03.2009
Verlag: Springer-Verlag
Erschienen in: Supportive Care in Cancer / Ausgabe 3/2009
Print ISSN: 0941-4355
Elektronische ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-008-0508-z

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The Efficacy of prophylactic Shakuyaku-Kanzo-to for myalgia and arthralgia following Carboplatin and Paclitaxel combination chemotherapy for non-small cell lung cancer