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Cancer Microenvironment

Erschienen in:

01.12.2010 | Review Paper

The Extracellular Matrix in Digestive Cancer

verfasst von: Daniel L. Worthley, Andrew S. Giraud, Timothy C. Wang

Erschienen in: Cancer Microenvironment | Ausgabe 1/2010

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Abstract

The extracellular components of the cancer microenvironment play a critical role in tumor initiation, progression and invasion. In this review we examine the normal formation and function of the basement membrane and extracellular matrix. We characterize the interactions between the matrix and the epithelium and explore the causes and consequences of the extracellular remodeling that accompanies carcinogenesis. Finally, we address the therapeutic possibilities of incorporating matrix as well as epithelial strategies in the management of digestive cancer.

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Titel: The Extracellular Matrix in Digestive Cancer
verfasst von: Daniel L. Worthley
Andrew S. Giraud
Timothy C. Wang
Publikationsdatum: 01.12.2010
Verlag: Springer Netherlands
Erschienen in: Cancer Microenvironment / Ausgabe 1/2010
Print ISSN: 1875-2292
Elektronische ISSN: 1875-2284
DOI: https://doi.org/10.1007/s12307-010-0053-4

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