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Current Hypertension Reports

Erschienen in:

01.01.2018 | Secondary Hypertension: Nervous System Mechanisms (M Wyss, Section Editor)

The Interactions of the Immune System and the Brain in Hypertension

verfasst von: Marialuisa Perrotta, Giuseppe Lembo, Daniela Carnevale

Erschienen in: Current Hypertension Reports | Ausgabe 1/2018

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Abstract

Purpose of Review

Hypertension still represents a huge health problem, causing death and disability and rising at epidemic levels worldwide. The availability of a vast array of antihypertensive therapeutic strategies still fails to adequately treat significant fractions of refractory patients. The possible explanation to this disappointing evidence should be ascribed to the fact that myriad of mechanisms contribute to onset and maintenance of hypertension. Although we have been able to develop strategies aimed at counteracting the single mechanisms identified as master regulators of blood pressure, we still lack strategies capable to approach at the complex interactions established among the different pathophysiological mechanisms.

Recent Findings

One of the most intriguing pathophysiological interactions in hypertension emerged in the very last years is the one established between the autonomic nervous system and immunity.

Summary

Here we briefly review the most important contributions revealing neural modulation of immunity in hypertension and how this novel concept is integrated in the already known multitude of regulations exerted by the autonomic nervous system in typical organs involved in blood pressure regulation.

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Titel: The Interactions of the Immune System and the Brain in Hypertension
verfasst von: Marialuisa Perrotta
Giuseppe Lembo
Daniela Carnevale
Publikationsdatum: 01.01.2018
Verlag: Springer US
Erschienen in: Current Hypertension Reports / Ausgabe 1/2018
Print ISSN: 1522-6417
Elektronische ISSN: 1534-3111
DOI: https://doi.org/10.1007/s11906-018-0808-8

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The Interactions of the Immune System and the Brain in Hypertension