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Erschienen in: Critical Care 2/2010

01.04.2010 | Commentary

The kinetics of T regulatory cells in shock: beyond sepsis

verfasst von: Eirini Christaki, Eleni Patrozou

Erschienen in: Critical Care | Ausgabe 2/2010

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Abstract

During the past decade, there have been an increasing number of studies investigating the precise role of T regulatory cells in human disease. First recognized for their ability to prevent autoimmunity, T regulatory cells control effector CD4+ and CD8+ T lymphocytes and innate immune cells by several different suppressive mechanisms, like cell to cell contact, secretion of inhibitory cytokines and cytolysis. This suppressive function of T regulatory cells could contribute in a similar way to the profound immune dysfunction seen in critical illness whether the latter is due to sepsis or severe injury.
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Metadaten
Titel
The kinetics of T regulatory cells in shock: beyond sepsis
verfasst von
Eirini Christaki
Eleni Patrozou
Publikationsdatum
01.04.2010
Verlag
BioMed Central
Erschienen in
Critical Care / Ausgabe 2/2010
Elektronische ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc8897

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