Background
Boffetta et al. [1] | Lee and Hamling [2] | |||
---|---|---|---|---|
Cancer | Na
| RR (95% CI)b
| Na
| RR (95% CI)b
|
Oropharyngeal | 13 | 1.8 (1.1–2.9) | 19 | 1.36 (1.04–1.77) |
- published since 1990 | Not given | 14 | 1.00 (0.83–1.20) | |
Oesophageal | 5 | 1.6 (1.1–2.3) | 7 | 1.13 (0.95–1.36) |
Pancreatic | 6 | 1.6 (1.1–2.2) | 7 | 1.07 (0.71–1.60) |
Lung | 5 | 1.2 (0.7–1.9) | 6 | 0.99 (0.71–1.37) |
Stomach | Not given | 8 | 1.03 (0.88–1.20) | |
Bladder | Not given | 10 | 0.95 (0.71–1.29) | |
Overall cancer | Not given | 7 | 0.98 (0.84–1.15) |
Objectives
Differences between the estimates from the two reviews
ST usea
| |||||||
---|---|---|---|---|---|---|---|
Ref | Type | Exposure | Inclusion of smokersb
| Reviewc
| Sex | Relative risk (95% CI) | Comments |
[3] | ST | Current | NS | L&H | M | 2.02 (0.53–7.74) | |
(CPS-I) | ST | Current | NS | B | M | 2.0 (0.5–7.7) | Estimates agreed
|
[3] | ST | Current | NS | L&H | M | 0.90 (0.12–6.71) | |
(CPS-II) | ST | Current | NS | B | M | 0.9 (0.1–6.7) | Estimates agreed
|
[4] | Snuff | Ever | SNS | L&H | M | 1.10 (0.50–2.41) | |
Snuff | Ever | SNS | B | M | 1.1 (0.5–2.4) | Estimates agreed
| |
[5] | Snuff | Ever | SNS | L&H | M | 0.7 (0.5–0.9) | |
Snuff | Ever | NS | B | M | 0.8 (0.4–1.7) | NS not SNS | |
[6] | Snuff | Ever | SNS | L&H | M | 3.1 (1.5–6.6) | Too recent to be included by B |
[7] | Chew | Ever | SNS | L&H | M+F | 2.05 (1.48–2.83)e
| Not included by B |
[8] | Chew | Ever | SNS | L&H | M | 2.00 (1.16–3.47)e
| Not included by B |
[9] | ST | Ever | SNS | L&H | M | 3.63 (1.02–12.95)e
| Not included by B |
[10] | Snuff | Ever | SNS | L&H | F | 2.67 (1.83–3.90)e
| |
Snuff | Ever | NSf
| B | F | 4.2 (2.6–6.7) | Whites | |
Snuff | Ever | NSf
| B | F | 1.5 (0.5–4.8) | Blacks | |
[11] | ST | Ever | SNS | B | M | 2.3 (0.2–12.9) | Tongue cancer |
ST | Ever | SNS | B | M | 11.2 (4.1–30.7) | Mouth cancer | |
Not included by L&H as no valid smoking adjustmentg
| |||||||
[12] | ST | Ever | NS | L&H | F | 6.2 (1.9–19.8) | |
ST | Ever | NS | B | F | 6.2 (1.9–19.8) | Estimates agree | |
[13] | Snuff | Ever | NS | L&H | M+F | 0.67 (0.08–5.75)e
| Not included by B |
[14] | ST | Ever | SNS | L&H | M+F | 1.04 (0.41–2.68)e
| Not included by B |
[15] | ST | Ever | SNS | L&H | M | 0.96 (0.70–1.33)e
| |
Chew | Ever | SNS | B | M | 1.0 (0.7–1.4) | Chew not ST | |
[16] | Chew | Ever | SNS | L&H | M | 1.11 (0.81–1.53)e
| |
Chew | Ever | NS | B | M | 2.3 (0.7–7.3) | NS not SNS | |
[17]h
| ST | Ever | SNS | L&H | M+F | 1.43 (0.64–3.21)e
| Not included by B |
[18] | Snuff | Ever | SNS | L&H | M | 0.98 (0.63–1.50)e
| |
Snuff | Ever | SNS | B | M | 1.4 (0.8–2.4) | Oral cancer excluding pharynx | |
[19] | Snuff | Ever | SNS | L&H | M+F | 0.8 (0.5–1.3) | Estimate for NS also available |
Snuff | Ever | SNS | B | M+F | 0.8 (0.5–1.3) | Estimates agree | |
[20] | ST | Ever | SNS | L&H | M | 1.0 (0.4–2.3) | Not included by B |
[21] | Snuff | Ever | SNS | L&H | M+F | 0.7 (0.3–1.3) | Not included by B |
Total | L&H | 1.36 (1.04–1.77) | 19 estimates | ||||
B | 1.8 (1.1–2.9) | 13 estimates |
ST usea
| |||||||
---|---|---|---|---|---|---|---|
Ref | Type | Exposure | Inclusion of smokersb
| Reviewc
| Sex | Relative risk (95% CI) | Comments |
[4] | Snuff | Ever | SNS | L&H | M | 1.40 (0.61–3.24) | |
Snuff | Ever | SNS | B | M | 1.4 (0.6–3.2) | Estimates agreed
| |
[22] | Snuff | Ever | SNS | L&H | M | 1.00 (0.79–1.27)e
| Estimate for NS also available |
Snuff | Ever | NS | B | M | 3.5 (1.6–7.6) | NS not SNS; squamous cell carcinoma not all oesophageal cancer | |
[23] | Chew | Ever | NS | L&H | M | 1.18 (0.28–4.90)e
| Not included by B |
Chew | Ever | NS | L&H | F | 2.69 (0.92–7.87)e
| Not included by B | |
[24] | ST | Ever | NS | L&H | M | 1.2 (0.1–13.3) | |
ST | Ever | NS | B | M | 1.2 (0.1–13.3) | Estimates agree | |
[18] | Snuff | Ever | SNS | L&H | M | 1.2 (0.7–2.2) | |
Snuff | Ever | SNS | B | M | 1.2 (0.7–2.2) | Estimates agree | |
[25] | Snuff | Ever | SNS | L&H | M+F | 1.31 (0.89–1.92)e
| |
Snuff | Ever | SNS | B | M+F | 1.4 (0.9–2.3) | Squamous cell carcinoma not all oesophageal cancer | |
Total | L&H | 1.13 (0.95–1.36) | 7 estimates | ||||
B | 1.6 (1.1–2.3) | 5 estimates |
ST usea
| |||||||
---|---|---|---|---|---|---|---|
Ref | Type | Exposure | Inclusion of smokersb
| Reviewc
| Sex | Relative risk (95% CI) | Comments |
[26] | ST | Ever | SNS | L&H | M | 1.7 (0.9–3.1) | |
ST | Ever | SNS | B | M | 1.7 (0.9–3.1) | Estimates agree | |
[4] | Snuff | Ever | SNS | L&H | M | 1.67 (1.12–2.50) | Estimates for NS also available |
Snuff | Ever | SNS | B | M | 1.7 (1.1–2.5) | Estimates agreed
| |
[5] | Snuff | Ever | SNS | L&H | M | 0.9 (0.7–1.2) | |
Snuff | Ever | NS | B | M | 2.0 (1.2–3.3) | NS not SNS | |
[27] | ST | Ever | SNS | L&H | M | 0.29 (0.09–0.92)e
| Not included by B |
[28] | Chew | Ever | NS | L&H | M | 2.82 (0.85–9.39) | Personal communication from Dr Muscat |
Chew | Ever | NSf
| B | M | 3.6 (1.0–12.8) | Estimate actually for non-current smokers | |
[29] | ST | Ever | NSg
| L&H | M+F | 1.1 (0.4–3.1) | |
ST | Ever | NS | B | M+F | 1.4 (0.5–3.6) | Estimate biased as pipe and cigar smokers included in numerator only | |
[30] | ST | Ever | SNS | L&H | M+F | 0.65 (0.43–0.97)e
| Estimate for NS also available |
Chew | Ever | NS | B | M+F | 0.6 (0.3–1.4) | Chew not ST; NS not SNS | |
Total | L&H | 1.07 (0.71–1.60) | 7 estimates | ||||
B | 1.6 (1.1–2.2) | 6 estimates |
ST usea
| |||||||
---|---|---|---|---|---|---|---|
Ref | Type | Exposure | Inclusion of smokersb
| Reviewc
| Sex | Relative risk (95% CI) | Comments |
[31] | ST | Ever | NS | L&H | F | 6.80 (1.60–28.5) | Not included by B |
[3] | ST | Current | NS | L&H | M | 1.08 (0.64–1.83) | |
(CPS-I) | ST | Current | NS | B | M | 1.1 (0.6–1.8) | Estimates agreed
|
[3] | ST | Ever | NS | L&H | M | 1.77 (1.14–2.74)e
| |
(CPS-II) | ST | Current | NS | B | M | 2.0 (1.2–3.2) | Current not ever exposure |
[4] | Snuff | Ever | SNS | L&H | M | 0.80 (0.61–1.05) | Estimate for NS also available |
Snuff | Ever | SNS | B | M | 0.8 (0.6–1.1) | Estimates agreed
| |
[5] | Snuff | Ever | SNS | L&H | M | 0.7 (0.6–0.7) | |
Snuff | Ever | NS | B | M | 0.8 (0.5–1.3) | NS not SNS | |
[27] | ST | Ever | SNS | L&H | M | 0.69 (0.47–1.00)e
| Not included by B |
Total | L&H | 0.99 (0.71–1.37) | 6 estimates | ||||
B | 1.2 (0.7–1.9) | 5 estimatesf
|