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01.03.2015 | Maternal-Fetal Medicine

The relationship between the VEGF/sVEGFR-1 ratio and threatened abortion

verfasst von: Uğur Keskin, Mustafa Ulubay, Murat Dede, Taner Ozgurtas, Yahya Kemal Koçyiğit, Fevzi Nuri Aydin, Ali Ergün

Erschienen in: Archives of Gynecology and Obstetrics | Ausgabe 3/2015

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Abstract

Purpose

The aim of this study was to evaluate the levels of vascular endothelial growth factor (VEGF), soluble VEGF receptor-1 (sVEGFR-1) and placenta growth factor (PlGF) and VEGF/SVEGFR-1 ratio in pregnant women with threatened abortion (TA) compared to uncomplicated pregnancies at the same gestational week.

Methods

Thirty-three pregnant women with TA and thirty-three pregnant women with uncomplicated pregnancies were included in this case–control study. The level of VEGF, sVEGFR-1, and PIGF was analyzed by enzyme-linked immunosorbent assay (ELISA). The primary purpose of this study was to compare the VEGF, sVEGFR- 1, and PlGF levels and VEGF/sVEGFR-1 ratios in pregnant women with TA and pregnant women with uncomplicated pregnancies. The secondary purpose of this study was to evaluate the correlation between serum levels of these markers and gestational age.

Results

The serum levels of the sVEGFR-1 [0.60 (0.21–1.68) vs. 0.24 (0.09–0.57) ng/ml], VEGF [39.10 (6.57–163.56) vs. 5.24 (0.84–15.08) ng/ml] and VEGF/SVEGFR-1 ratio [68.64 (6.45–550.48) vs 24.12 (2.63–72.63)] were significantly elevated in women with TA (respectively, p: 0.001, p: 0.001, p: 0.001). However, PlGF did not elevate in women with TA [20.80 (3.13–93.11) vs 20.16 (1.22–49.91) ng/ml] (p: 0.473).

Conclusion

These findings support the hypothesis that increased levels of the VEGF and sVEGFR-1 and VEGF/SVEGFR-1 ratio may be associated with the pathogenesis of TA.

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Titel: The relationship between the VEGF/sVEGFR-1 ratio and threatened abortion
verfasst von: Uğur Keskin
Mustafa Ulubay
Murat Dede
Taner Ozgurtas
Yahya Kemal Koçyiğit
Fevzi Nuri Aydin
Ali Ergün
Publikationsdatum: 01.03.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Archives of Gynecology and Obstetrics / Ausgabe 3/2015
Print ISSN: 0932-0067
Elektronische ISSN: 1432-0711
DOI: https://doi.org/10.1007/s00404-014-3452-9

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The relationship between the VEGF/sVEGFR-1 ratio and threatened abortion