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01.06.2009 | Aktuelles

Tiefe Hirnstimulation bei idiopathischem Parkinson-Syndrom

Empfehlungen der Deutschen Arbeitsgemeinschaft Tiefe Hirnstimulation

verfasst von: R. Hilker, R. Benecke, G. Deuschl, W. Fogel, A. Kupsch, C. Schrader, F. Sixel-Döring, L. Timmermann, J. Volkmann, Dr. M. Lange

Erschienen in: Der Nervenarzt | Ausgabe 6/2009

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Zusammenfassung

Die tiefe Hirnstimulation (THS) bessert bei idiopathischem Parkinson-Syndrom prinzipiell Levodopa-responsive Symptome und Tremor. Die Stimulation des Nucleus subthalamicus (STN) ist in Bezug auf die Kontrolle von Fluktuationen und die Off-Zeit-Reduktion der rein medikamentösen Therapie überlegen. Verlaufsuntersuchungen zeigen eine langfristig anhaltende Wirksamkeit der STN-Stimulation, auch wenn die Erkrankung selbst weiter progredient ist. Die STN-THS erlaubt im Gegensatz zur Stimulation des Globus pallidus internus (GPi) zumeist die Reduktion der dopaminergen Medikation. Die Stimulation im Nucleus ventralis intermedius thalami (VIM) stellt eine Alternative bei älteren Patienten mit medikamentös nicht beherrschbarem Tremor dar. Eine konsequente und sorgfältige Indikationsstellung ist besonders bei Parkinson-Patienten zur Minimierung möglicher Operationsrisiken und unerwünschter Wirkungen der THS unabdingbar. Diese Arbeit fasst die aktuelle Datenlage zu dieser Thematik in Form von Empfehlungen zusammen, welche innerhalb der Arbeitsgemeinschaft Tiefe Hirnstimulation erarbeitet wurden.

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Titel: Tiefe Hirnstimulation bei idiopathischem Parkinson-Syndrom
Empfehlungen der Deutschen Arbeitsgemeinschaft Tiefe Hirnstimulation
verfasst von: R. Hilker
R. Benecke
G. Deuschl
W. Fogel
A. Kupsch
C. Schrader
F. Sixel-Döring
L. Timmermann
J. Volkmann
Dr. M. Lange
Publikationsdatum: 01.06.2009
Verlag: Springer-Verlag
Erschienen in: Der Nervenarzt / Ausgabe 6/2009
Print ISSN: 0028-2804
Elektronische ISSN: 1433-0407
DOI: https://doi.org/10.1007/s00115-009-2695-3

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