Background
Methods
Type and populations of study
Data collected
Statistical analysis
Results
General description of the cohort
The intensive phase of treatment as death time
Survival time (months) | Number at risk | Deaths | Proportion of deaths (%) |
---|---|---|---|
0–1 | 1362 | 31 | 34 |
1–2 | 1317 | 17 | 19 |
2–3 | 1286 | 16 | 18 |
3–4 | 1255 | 10 | 11 |
4–5 | 1221 | 7 | 8 |
5–6 | 1186 | 8 | 9 |
6–7 | 42 | 1 | 1 |
7–8 | 30 | 0 | 0 |
Factors affecting survival time
Risk factors
≤
0.001) male sex (HR 0.61; 95% CI [0.40–0.93] p = 0.023), the initial weight < 40 kg (HR 4.06; 95% CI [2.42–6.81], p ≤
0.001), positive HIV status (HR 8.97; 95% CI [4.50–17.86, p ≤
0.001) and unknown (HR 2.18; 95% CI [1.17–4.09], p = 0.015) were the factors significantly associated with death in SPPTB (Table 2).
Participants characteristics | SPPTB deaths | HRi [95% CIii] | P-value | ||
---|---|---|---|---|---|
Yes | No | ||||
Age | < 45 years of age | 58 | 1023 | 1 | - |
≥ 45 years old | 32 | 249 | 2.16 [1.40–3.33] | ≤0.001 | |
Sex | Female | 37 | 375 | 1 | – |
Male | 53 | 897 | 0.61 [0.40–0.93] | 0.023 | |
Initial weight | ≥ 40 kg | 72 | 1205 | 1 | – |
< 40 kg | 18 | 67 | 4.06 [2.42–6.81] | ≤0.001 | |
Type of SPPTB | New casei | 81 | 1154 | 1 | – |
Old caseii | 9 | 118 | 1.00 [0.50–2.03] | 0.992 | |
HIV | Negative | 12 | 400 | 1 | ≤0.001 |
Unknown | 53 | 793 | 2.18 [1.17–4.09] | ||
Positive | 25 | 79 | 8.97 [4.50–17.86] | ||
Smear density | 1+ | 27 | 325 | 1 | 0.25 |
2+ | 10 | 230 | 0,55 [0.27–1,14] | ||
3+ | 53 | 717 | 0.92 [0.57–1.46] | ||
Treatment center | Semi-rural | 59 | 823 | 1 | – |
Urbain | 31 | 449 | 0.96 [0.62–1.49] | 0.865 |
≤
0.001), weight < 40 kg (HR 2.20 95% CI [1.89–5, 42], p ≤
0.001), HIV status (unknown HIV status (HR 1.96, 95% CI [1.04–4.67], p = 0.037) and positive HIV status (HR 7.10 95% CI [3.53–14.26], p ≤
0.001) were the factors independently associated with death in SPPTB (Table 3).
Participants characteristics | HR | 5%CI | P | |
---|---|---|---|---|
Age | < 45 years of age | 1 | ||
≥ 45 years old | 2.09 | [1.35–3.23] | ≤0.001 | |
Sex | Female | 1 | ||
Male | 1.05 | [0.65–1.69] | 0.840 | |
Initial weight | ≥ 40 kg | 1 | ||
< 40 kg | 2.20 | [1.89–5.42] | ≤0.001 | |
HIV | Negative | 1 | ||
Unknown | 1.96 | [1.04–3.67] | 0.037 | |
Positive | 7.10 | [3.53–14.26] | ≤0.001 |