Erschienen in:
01.04.2003 | Comment
—to: Pani MA, Van Autreve J, Van der Auwera BJ, Gorus FK, Badenhoop K (2002) Non-transmitted maternal HLA DQ2 or DQ8 alleles and risk of Type 1 diabetes in offspring: the importance of foetal or post partum exposure to diabetogenic molecules. Diabetologia 45:1340–1343
verfasst von:
Dr. A. P. Lambert, K. M. Gillespie, P. J. Bingley, E. A. M. Gale
Erschienen in:
Diabetologia
|
Ausgabe 4/2003
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Excerpt
To the Editor: Pani et al. [
1] investigated children with Type 1 diabetes and their parents, and found that high risk HLA class II haplotypes were not only transmitted more frequently from both parents to the child with diabetes, but were also more common among the maternal non-transmitted haplotypes than paternal. They hypothesised that low exposure of the child to maternal non-transmitted haplotypes in retained maternal cells—microchimerism—might contribute to increased disease susceptibility. Maternal cells could persist into adult life [
2] and contribute to the development of autoimmune disease in the offspring [
3]. We have tried to replicate the findings of Pani et al. in a large United Kingdom population of families with Type 1 diabetes. …