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Erschienen in:
01.08.2011 | Clinical Investigation
Transcatheter Infusion of Epirubicin in Water-in-Oil-in-Water Emulsion via a Cystic Artery for the Treatment of Hepatocellular Carcinoma
Erschienen in: CardioVascular and Interventional Radiology | Ausgabe 4/2011
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Purpose
We have previously reported the clinical efficacy of water-in-oil-in-water (W/O/W) emulsion containing anticancer agent. The purpose of this study was to evaluate the safety and effectiveness of transcatheter arterial infusion (TAI) of W/O/W emulsion via a cystic artery for hepatocellular carcinoma (HCC).
Methods
TAI of a W/O/W emulsion was performed at our institute in five patients with Stage III or IV HCC with blood supply from the cystic artery. In all patients, 2–12 ml W/O/W emulsion was infused via a cystic artery. Therapeutic effects and complications were evaluated in these patients.
Results
Of the five patients treated, one achieved a complete response and two achieved a partial response. After treatment, acute cholecystitis or gallbladder ischemia that required treatment was not encountered in any patient.
Conclusions
W/O/W emulsion can be safely infused via a cystic artery without major complications; it is a good therapeutic option for the patients with advanced HCC fed by a cystic artery.