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European Journal of Nutrition

Erschienen in:

01.08.2015 | Original Contribution

When early life growth restriction in rats is followed by attenuated postnatal growth: effects on cardiac function in adulthood

verfasst von: Vladislava Zohdi, James T. Pearson, Michelle M. Kett, Paul Lombardo, Michal Schneider, M. Jane Black

Erschienen in: European Journal of Nutrition | Ausgabe 5/2015

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Abstract

Purpose

Epidemiological and experimental studies demonstrate that intrauterine growth restriction (IUGR) followed by accelerated postnatal growth leads to increased risk of developing cardiac disease in adulthood. The aim of this study was to examine the effect of early life growth restriction on cardiac structure and function in young adult rats.

Methods

IUGR was induced in Wistar Kyoto dams through administration of a low protein diet (LPD; 8.7 % casein) during pregnancy and lactation; controls received a normal protein diet (NPD; 20 % casein). Cardiac function and structure were assessed in female NPD (n = 7) and LPD (n = 7) offspring at 18 weeks of age by echocardiography and pressure–volume techniques, and systolic blood pressure by tail–cuff sphygmomanometry.

Results

LPD offspring remained significantly smaller throughout life compared to controls. There were no differences in the levels of systolic blood pressure, left ventricular cardiac dimensions, heart rate, ejection fraction and fractional shortening of the cardiac muscle between the investigated groups. Aortic peak systolic velocity was significantly reduced in the LPD group (P = 0.02).

Conclusion

Our findings support the idea that the programming of adult cardiovascular disease can be prevented or delayed in IUGR offspring when postnatal growth trajectory resembles that of in utero.

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Titel: When early life growth restriction in rats is followed by attenuated postnatal growth: effects on cardiac function in adulthood
verfasst von: Vladislava Zohdi
James T. Pearson
Michelle M. Kett
Paul Lombardo
Michal Schneider
M. Jane Black
Publikationsdatum: 01.08.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: European Journal of Nutrition / Ausgabe 5/2015
Print ISSN: 1436-6207
Elektronische ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-014-0752-6

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