Erschienen in:
01.04.2010 | Commentary
Where does the lactate come from? A rare cause of reversible inhibition of mitochondrial respiration
verfasst von:
Bruno Levy, Pierre Perez, Jessica Perny
Erschienen in:
Critical Care
|
Ausgabe 2/2010
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Abstract
Biguanide poisoning is associated with lactic acidosis. The exact mechanism of biguanide-induced lactic acidosis is not well understood. In the previous issue of Critical Care, Protti and colleagues demonstrated that biguanide-induced lactic acidosis may be due in part to a reversible inhibition of mitochondrial respiration. Thus, in the absence of an antidote, increased drug elimination through dialysis is logical.