nach oben

Clinical Neuroradiology

Erschienen in:

01.10.2015 | Original Article

Whole Brain ¹H-Spectroscopy: A Developing Technique for Advanced Analysis of Cerebral Metabolism

verfasst von: X.-Q. Ding, H. Lanfermann

Erschienen in: Clinical Neuroradiology | Sonderheft 2/2015

Einloggen, um Zugang zu erhalten

Abstract

Objective

Accompanying the advance of neuroscientific research and modern therapeutic methods, efforts have been made to develop more practical and effective advanced magnetic resonance (MR) spectroscopic techniques.

Methods

We present a brief overview on ¹H-MRS techniques in neuroradiological diagnosis and several application examples of recently reported whole brain MR spectroscopic imaging technique (wbMRSI).

Results

Despite the benefits of using established ¹H-MRS techniques both single voxel MR spectroscopy (SVS) and chemical shift imaging (CSI) techniques suffer from limited spatial coverage. It is always necessary to define prior to the MRS examination which brain structure is physiologically or pathologically involved and thus should be targeted with ¹H-MRS. In contrast, the advanced wbMRSI allows estimating metabolite changes within a much larger brain region and at multiple brain structures simultaneously.

Conclusions

As a developing technique for advanced analysis of cerebral metabolism a wide application of the wbMRSI in both clinical diagnostics and neuroscience could be expected.

Oz G, Alger JR, Barker PB, Bartha R, Bizzi A, Boesch C, Bolan PJ, Brindle KM, Cudalbu C, Dinçer A, Dydak U, Emir UE, Frahm J, González RG, Gruber S, Gruetter R, Gupta RK, Heerschap A, Henning A, Hetherington HP, Howe FA, Hüppi PS, Hurd RE, Kantarci K, Klomp DW, Kreis R, Kruiskamp MJ, Leach MO, Lin AP, Luijten PR, Marjańska M, Maudsley AA, Meyerhoff DJ, Mountford CE, Nelson SJ, Pamir MN, Pan JW, Peet AC, Poptani H, Posse S, Pouwels PJ, Ratai EM, Ross BD, Scheenen TW, Schuster C, Smith IC, Soher BJ, Tkáč I, Vigneron DB, Kauppinen RA; MRS Consensus Group. Clinical proton MR spectroscopy in central nervous system disorders. Radiology. 2014;270:658–79.PubMedCentralCrossRefPubMed

Horska A, Barker PB. Imaging of brain tumors: MR spectroscopy and metabolic imaging. Neuroimaging. 2010;20:293–310.CrossRef

Alderliesten T, de Vries LS, Benders MJ, Koopman C, Groenendaal F. MR imaging and outcome of term neonates with perinatal asphyxia: value of diffusion-weighted MR imaging and ¹H MR spectroscopy. Radiology. 2011;261:235–42.CrossRefPubMed

Wattjes MP, Harzheim M, Lutterbey GG, Bogdanow M, Schild HH, Träber F. High field MR imaging and 1H-MR spectroscopy in clinically isolated syndromes suggestive of multiple sclerosis: correlation between metabolic alterations and diagnostic MR imaging criteria. J Neurol. 2008;255:56–63.CrossRefPubMed

Kayabas U, Alkan A, Firat AK, Karakas HM, Bayindir Y, Yetkin F. Magnetic resonance spectroscopy features of normal-appearing white matter in patients with acute brucellosis. Eur J Radiol. 2008;65:417–20.CrossRefPubMed

Pilatus U, Lais C, Rochmont Adu M, Kratzsch T, Frölich L, Maurer K, Zanella FE, Lanfermann H, Pantel J. Conversion to dementia in mild cognitive impairment is associated with decline of N-actylaspartate and creatine as revealed by magnetic resonance spectroscopy. Psychiatry Res. 2009;173:1–7.CrossRefPubMed

Bustillo JR. Use of proton magnetic resonance spectroscopy in the treatment of psychiatric disorders: a critical update. Dialogues Clin Neurosci. 2013;15:329–37.PubMedCentralPubMed

Maudsley AA, Domenig C, Sheriff S. Reproducibility of serial whole-brain MR spectroscopic imaging. NMR Biomed. 2010;23:251–6.PubMedCentralPubMed

Ding XQ, Maudsley AA, Sabati M, Sheriff S, Dellani PR, Lanfermann H. Reproducibility and reliability of short-TE whole-brain MR spectroscopic imaging of human brain at 3T. Magn Reson Med. 2015;73:921–8.CrossRefPubMed

10.

Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med. 1993;30:672–9.CrossRefPubMed

11.

Naressi A, Couturier C, Castang I, de Beer R, Graveron-Demilly D. Java-based graphical user interface for MRUI, a software package for quantitation of in vivo/medical magnetic resonance spectroscopy signals. Comput Biol Med. 2001;31:269–86.CrossRefPubMed

12.

Pouwels PJ, Brockmann K, Kruse B, Wilken B, Wick M, Hanefeld F, Frahm J. Regional age dependence of human brain metabolites from infancy to adulthood as detected by quantitative localized proton MRS. Pediatr Res. 1999;46:474–85.CrossRefPubMed

13.

Castillo M. History and evolution of brain tumor imaging: insights through radiology. Radiology. 2014;273:S111–25.CrossRefPubMed

14.

Svolos P, Kousi E, Kapsalaki E, Theodorou K, Fezoulidis I, Kappas C, Tsougos I. The role of diffusion and perfusion weighted imaging in the differential diagnosis of cerebral tumors: a review and future perspectives. Cancer Imaging. 2014;14:20.PubMedCentralPubMed

15.

Hattingen E, Raab P, Franz K, Lanfermann H, Setzer M, Gerlach R, Zanella FE, Pilatus U. Prognostic value of choline and creatine in WHO grade II gliomas. Neuroradiology. 2008;50:759–67.CrossRefPubMed

16.

Hourani R, Brant LJ, Rizk T, Weingart JD, Barker PB, Horská A. Can proton MR spectroscopic and perfusion imaging differentiate between neoplastic and nonneoplastic brain lesions in adults? AJNR Am J Neuroradiol. 2008;29:366–72.PubMedCentralCrossRefPubMed

17.

Hermann EJ, Hattingen E, Krauss JK, Marquardt G, Pilatus U, Franz K, Setzer M, Gasser T, Tews DS, Zanella FE, Seifert V, Lanfermann H. Stereotactic biopsy in gliomas guided by 3-tesla 1H-chemical-shift imaging of choline. Stereotact Funct Neurosurg. 2008;86:300–7.CrossRefPubMed

18.

Nelson SJ, Graves E, Pirzkall A, Li X, Antiniw Chan A, Vigneron DB, McKnight TR. In vivo molecular imaging for planning radiation therapy of gliomas: an application of 1H MRSI. J Magn Reson Imaging. 2002;16:464–76.CrossRefPubMed

19.

Gordon EM, Breeden AL, Bean SE, Vaidya CJ. Working memory-related changes in functional connectivity persist beyond task disengagement. Hum Brain Mapp. 2014;35:104–17.CrossRef

20.

Maudsley AA, Darkazanli A, Alger JR, Hall LO, Schuff N, Studholme C, Yu Y, Ebel A, Frew A, Goldgof D, Gu Y, Pagare R, Rousseau F, Sivasankaran K, Soher BJ, Weber P, Young K, Zhu X. Comprehensive processing, display and analysis for in vivo MR spectroscopic imaging. NMR Biomed. 2006;19:492–503.PubMedCentralCrossRefPubMed

21.

Maudsley AA, Domenig C, Govind V, Darkazanli A, Studholme C, Arheart K, Bloomer C. Mapping of brain metabolite distributions by volumetric proton MR spectroscopic imaging (MRSI). Magn Reson Med. 2009;61:548–59.PubMedCentralCrossRefPubMed

22.

Maudsley AA, Govind V, Arheart KL. Associations of age, gender and body mass with 1H MR-observed brain metabolites and tissue distributions. NMR Biomed. 2012;25:580–93.PubMedCentralCrossRefPubMed

23.

Govind V, Sharma KR, Maudsley AA, Arheart KL, Saigal G, Sheriff S. Comprehensive evaluation of corticospinal tract metabolites in amyotrophic lateral sclerosis using whole-brain 1H MR spectroscopy. PloS one. 2012;7:e35607.PubMedCentralCrossRefPubMed

24.

Stagg CJ, Knight S, Talbot K, Jenkinson M, Maudsley AA, Turner MR. Whole-brain magnetic resonance spectroscopic imaging measures are related to disability in ALS. Neurology. 2013;80:610–5.PubMedCentralCrossRefPubMed

25.

Maudsley AA, Roy B, Gupta RK, Sheriff S, Awasthi R, Gu M, Husain N, Mohakud S, Behari S, Spielman DM. Association of metabolite concentrations and water diffusivity in normal appearing brain tissue with glioma grade. J Neuroimaging. 2014;24:585–9.CrossRefPubMed

26.

Posse S, Otazo R, Dager SR, Alger J. MR spectroscopic imaging: principles and recent advances. J Magn Reson Imaging. 2013;37:1301–25.CrossRefPubMed

27.

Dydak U, Xu JS, Marjanska M, Posse S. Proceedings of the 19th Annual Meeting of ISMRM. In, 19th Annual Meeting of ISMRM. Montreal, Canada; 2011.

Titel: Whole Brain 1H-Spectroscopy: A Developing Technique for Advanced Analysis of Cerebral Metabolism
verfasst von: X.-Q. Ding
H. Lanfermann
Publikationsdatum: 01.10.2015
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Neuroradiology / Ausgabe Sonderheft 2/2015
Print ISSN: 1869-1439
Elektronische ISSN: 1869-1447
DOI: https://doi.org/10.1007/s00062-015-0428-5

Update Radiologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Whole Brain ¹H-Spectroscopy: A Developing Technique for Advanced Analysis of Cerebral Metabolism

Abstract

Objective

Methods

Results

Conclusions

Neu im Fachgebiet Radiologie

Akuter Schwindel: Wann lohnt sich eine MRT?

Screening-Mammografie offenbart erhöhtes Herz-Kreislauf-Risiko

S3-Leitlinie zu Pankreaskrebs aktualisiert

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

Update Radiologie

Springer Medizin

Abstract

Objective

Methods

Results

Conclusions

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Sonderheft 2/2015

MRI in the Diagnosis and Monitoring of Multiple Sclerosis: An Update

Differential Diagnosis of Acute Myelopathies: An Update

Hybrid MR-PET in Neuroimaging

Imaging Neurodegeneration: Steps Toward Brain Network-Based Pathophysiology and Its Potential for Multi-modal Imaging Diagnostics

The Dural AV-Fistula (DAVF), the Most Frequent Acquired Vascular Malformation of the Central Nervous System (CNS)

Das Referenzzentrum für Neuroradiologie für die Hirntumorstudien der deutschen Gesellschaft für pädiatrische Onkologie und Hämatologie (GPOH)

Neu im Fachgebiet Radiologie

Akuter Schwindel: Wann lohnt sich eine MRT?

Screening-Mammografie offenbart erhöhtes Herz-Kreislauf-Risiko

S3-Leitlinie zu Pankreaskrebs aktualisiert

Fünf Dinge, die im Kindernotfall besser zu unterlassen sind

Update Radiologie