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Zytokinregulation und Schmerz

Ergebnisse tierexperimenteller und klinischer Forschung

verfasst von: Dr. N. Üçeyler, C. Sommer

Erschienen in: Der Schmerz | Ausgabe 6/2008

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Zusammenfassung

Zytokine sind lösliche Peptide und Proteine, die im Organismus überwiegend von Immunzellen produziert und sezerniert werden. In zahlreichen Tiermodellen gehen eine endogene Vermehrung oder exogene Zufuhr proinflammatorischer Zytokine mit Schmerzverhalten einher. Andererseits kann dieses Schmerzverhalten durch Zytokininhibitoren in Modellen für entzündliche und neuropathische Schmerzen reduziert werden. Etliche Studien weisen auch auf die Bedeutung von Zytokinen bei unterschiedlichen schmerzhaften Erkrankungen beim Menschen hin. Bei verschiedenen chronischen Schmerzsyndromen findet sich systemisch ein proinflammatorisches Zytokinprofil assoziiert. Bei manchen Schmerzsyndromen ist dieses proinflammatorische Profil begleitet von einem Mangel an analgetisch wirksamen antiinflammatorischen Zytokinen. Eine Reihe von Fallberichten und offenen Studien, jedoch auch einige kontrollierte Studien zeigten Behandlungserfolge mit Zytokininhibitoren bei Schmerzen. Der folgende Artikel fasst die wesentlichen Befunde aus tierexperimenteller und klinischer Forschung zur Rolle von Zytokinen bei Schmerz und zur potenziellen Bedeutung zytokinmodulierender Substanzen in der Schmerztherapie zusammen.

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Titel: Zytokinregulation und Schmerz
Ergebnisse tierexperimenteller und klinischer Forschung
verfasst von: Dr. N. Üçeyler
C. Sommer
Publikationsdatum: 01.12.2008
Verlag: Springer-Verlag
Erschienen in: Der Schmerz / Ausgabe 6/2008
Print ISSN: 0932-433X
Elektronische ISSN: 1432-2129
DOI: https://doi.org/10.1007/s00482-008-0706-0

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