Conclusions
Because of its extended blood circulating life, fewer injections of smaller amounts of Oncaspar than unmodified asparaginases are required to maintain blood asparagine levels at low, therapeutically effective levels. While immune responses do occur with Oncaspar they are fewer than with unmodified asparaginases. Oncaspar might be even more effective if given in the first level of treatment.
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Davis, F.F. (2004). PEG-Adenosine Deaminase and PEG-Asparaginase. In: Maeda, H., Kabanov, A., Kataoka, K., Okano, T. (eds) Polymer Drugs in the Clinical Stage. Advances in Experimental Medicine and Biology, vol 519. Springer, Boston, MA. https://doi.org/10.1007/0-306-47932-X_3
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DOI: https://doi.org/10.1007/0-306-47932-X_3
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