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Renal Tumors

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Minimally Invasive Tumor Therapies

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 167))

9.6 Summary

The treatment of RCC is rapidly changing. The introduction of minimally invasive thermal ablation techniques offers a safe and accurate alternative to open surgery in the treatment of renal tumors. Because of its technical benefits, percutaneous radiofrequency ablation took the lead among these minimally invasive techniques. Supported by convincing results from experimental studies, patient data prove this procedure to be safe and efficient. As a minimally invasive and nephron-sparing technique, it is well suited for patients with a single kidney, multiple tumors, or contraindications for open surgery.

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References

  1. Jemal A, Tiwari R, Murray T, Ghafoor A, Samuels A, Ward E, Feuer EJ, Thun M (2004) Cancer statistics, 2004. CA Cancer J Clin 54:8–29

    PubMed  Google Scholar 

  2. Pantuck AJ, Zisman A, Belldegrun AS (2001) The changing natural history of renal cell carcinoma. J Urol 166:297–301

    Article  Google Scholar 

  3. Homma Y, Kawabe K, Kitamura T, Nishimura Y, Shinohara M, Kondo Y, Saito I, Minowada S, Asakage Y (1995) Increased incidental detection and reduced mortality in renal cancer — recent retrospective analysis at eight institutions. Int J Urol 2:77–80

    Article  PubMed  CAS  Google Scholar 

  4. Zagoria RJ, Dyer RB (1998) The small renal mass: detection, characterization, and management. Abdom Imaging 23:256–265

    Article  PubMed  CAS  Google Scholar 

  5. Guinan PD, Vogelzang NJ, Fremgen AM, Chmiel JS, Sylvester JL, Sener SF, Imperato JP (1995) Renal cell carcinoma: tumor size, stage and survival. Members of the Cancer Incidence and End Results Committee. J Urol 153:901–903

    Article  PubMed  CAS  Google Scholar 

  6. Thrasher JB, Paulson DF (1993) Prognostic factors in renal cancer. Urol Clin North Am 20:247–262

    PubMed  CAS  Google Scholar 

  7. Vogelzang NJ, Stadler WM (1988) Kidney cancer. Lancet 352:1691–1696

    Article  Google Scholar 

  8. Uzzo RG, Novick AC (2001) Nephron sparing surgery for renal tumors: indications techniques and outcomes. J Urol 166:6–18

    Article  PubMed  CAS  Google Scholar 

  9. Fergany AF, Hafez KS, Novick AC (2000) Longterm results of nephron-sparing surgery for localized renal cell carcinoma: 10-year follow up. J Urol 163:442–445

    Article  PubMed  CAS  Google Scholar 

  10. Herr HW (1999) Partial nephrectomy for unilateral renal cell carcinoma and a normal contralateral kidney: 10-year follow-up. J Urol 1161:33–35

    Google Scholar 

  11. Moll V, Becht E, Ziegler M (1993) Kidney preserving surgery in renal cell tumors: indications, techniques and results in 152 patients. J Urol 150:319–323

    PubMed  CAS  Google Scholar 

  12. Zlotta AR, Wildschutz T, Raviv G, Peny MO, van Gansbeke D, Noel JC, Schulman CC (1997) Radiofrequency interstitial tumor ablation (RITA) is a possible new modality for treatment of renal cancer: ex vivo and in vivo experience. J Endourol 11:251–258

    PubMed  CAS  Google Scholar 

  13. Munver R, Threatt CB, Delvecchio FC, Preminger GM, Polascik TJ (2002) Hypertonic saline-augmented radiofrequency ablation of the VX-2 tumor implanted in the rabbit kidney: a short-term survival pilot study. Urology 60:170–175

    Article  PubMed  Google Scholar 

  14. Hsu TH, Fidler ME, Gill IS (2000) Radiofrequency ablation of the kidney: acute and chronic histology in porcine model. Urol 56:872–875

    Article  PubMed  CAS  Google Scholar 

  15. Crowley JD, Shelton J, Iverson AJ, Burton MP, Dalrymple NC, Bishoff JT (2000) Laparoscopic and computed tomography-guided percutaneous radiofrequency ablation of renal tissue: acute and chronic effects in an animal model. Urology 57:976–980

    Article  Google Scholar 

  16. Polascik TJ, Hamper U, Lee BR, Dai Y, Hilton J, Magee CA, Crone JK, Shue MJ, Ferrell M, Trapanotto V, Adiletta M, Partin AW (1999) Ablation of renal tumors in a rabbit model with interstitial saline-augmented radiofrequency energy: preliminary report of a new technology. Urology 53:465–472

    Article  PubMed  CAS  Google Scholar 

  17. Aschoff AJ, Sulman A, Martinez M, Duerk JL, Resnick MI, MacLennan GT, Lewin JS (2001) Perfusion-modulated MR imaging-guided radiofrequency ablation of the kidney in a porcine model. AJR Am J Roentgenol 177:151–158

    PubMed  CAS  Google Scholar 

  18. Chang I, Mikityansky I, Wray-Cahen D, Pritchard WF, Karanian JW, Wood BJ (2004) Effects of perfusion on radiofrequency ablation in swine kidneys. Radiology 231:500–505

    PubMed  Google Scholar 

  19. Corwin TS, Lindberg G, Traxer O, Gettman MT, Smith TG, Pearle MS, Cadeddu JA (2001) Laparoscopic radiofrequency thermal ablation of renal tissue with and without hilar occlusion. J Urol 166:281–284

    Article  PubMed  CAS  Google Scholar 

  20. Gervais DA, McGovern FJ, Arellano RS, McDougal WS, Mueller PR (2005) Radiofrequency ablation of renal cell carcinoma: part 1, indications, results, and role in patient management over a 6-year period and ablation of 100 tumors. AJR Am J Roentgenol 185:64–71

    PubMed  Google Scholar 

  21. Neeman Z, Sarin S, Coleman J, Fojo T, Wood BJ (2005) Radiofrequency ablation for tumorrelated massive hematuria. J Vasc Interv Radiol 16:417–421

    PubMed  Google Scholar 

  22. Brown SD, Vansonnenberg E, Morrison PR, Diller L, Shamberger RC (2005) CT-guided radiofrequency ablation of pediatric Wilms tumor in a solitary kidney. Pediatr Radiol 39:923–928

    Article  Google Scholar 

  23. Zagoria RJ, Chen MY, Kavanagh PV, Torti FM (2001) Radio frequency ablation of lung metastases from renal cell carcinoma. J Urol 166:1827–1828

    Article  PubMed  CAS  Google Scholar 

  24. Gervais DA, Arellano RS, Mueller PR (2002) Percutaneous radiofrequency ablation of nodal metastases. Cardiovasc Intervent Radiol 25:547–549

    Article  PubMed  Google Scholar 

  25. Goetz MP, Callstrom MR, Charboneau JW, Farrell MA, Maus TP, Welch TJ, Wong GY, Sloan JA, Novotny PJ, Petersen IA, Beres RA, Regge D, Capanna R, Saker MB, Gronemeyer DH, Gevargez A, Ahrar K, Choti MA, de Baere TJ, Rubin J (2004) Percutaneous image-guided radiofrequency ablation of painful metastases involving bone: a multicenter study. J Clin Oncol 22:300–306

    Article  PubMed  Google Scholar 

  26. Goldberg SN, Gazelle GS, Mueller PR (2000) Thermal ablation therapy for focal malignancy: a unified approach to underlying principles, techniques, and diagnostic imaging guidance. AJR Am J Ronetgenol 174:323–331

    CAS  Google Scholar 

  27. Rendon RA, Kachura JR, Sweet JM, Gertner MR, Sherar MD, Robinette M, Tsihlias J, Trachtenberg J, Sampson H, Jewett MA (2002) The uncertainty of radio frequency treatment of renal cell carcinoma: findings at immediate and delayed nephrectomy. J Urol 167:1587–1592

    Article  PubMed  Google Scholar 

  28. Gervais DA, McGovern FJ, Arellano RS, McDougal SW, Mueller PR (2003) Renal cell carcinoma: clinical experience and technical success with radio-frequency ablation of 42 tumors. Radiology 226:417–424

    PubMed  Google Scholar 

  29. Farrell MA, Charboneau JW, Callstrom MR, Reading CC, Engen DE, Blute ML (2003) Paranephric water instillation: a technique to prevent bowel injury during percutaneous renal radiofrequency ablation. AJR Am J Roentgenol 181:1315–1317

    PubMed  CAS  Google Scholar 

  30. Schultze D, Morris CS, Bhave AD, Worgan BA, Najarian KE (2003) Radiofrequency ablation of renal transitional cell carcinoma with protective cold saline infusion. J Vasc Interv Radiol 14:489–492

    PubMed  Google Scholar 

  31. Hall WH, McGahan JP, Link DP, deVere White RW (2000) Combined embolization and percutaneous radiofrequency ablation of a solid renal tumor. AJR Am J Roentgenol 174:1592–1594

    PubMed  CAS  Google Scholar 

  32. Tacke J, Mahnken A, Bucker A, Rohde D, Gunther RW (2001) Nephron-sparing percutaneous ablation of a 5 cm renal cell carcinoma by superselective embolization and percutaneous RF ablation. Rofo 173:980–983

    PubMed  CAS  Google Scholar 

  33. Mahnken A, Rohde D, Brkovic D, Günther RW, Tacke J (2005) Percutaneous radiofrequency ablation of renal cell carcinoma: preliminary results. Acta Radiol 46:208–214

    Article  PubMed  CAS  Google Scholar 

  34. Rendon RA, Gertner MR, Sherar MD, Asch MR, Kachura JR, Sweet J, Jewett MA (2001) Development of a radiofrequency based thermal therapy technique in an in vivo porcine model for the treatment of small renal masses. J Urol 166:292–298

    Article  PubMed  CAS  Google Scholar 

  35. Merkle EM, Shonk JR, Duerk JL, Jacobs GH, Lewin JS (1999) MR-guided RF thermal ablation of the kidney in a porcine model. AJR Am J Roentgenol 173:645–651

    PubMed  CAS  Google Scholar 

  36. Tuncali K, vanSonnenberg E, Shankar S, Mortele KJ, Cibas ES, Silverman SG (2004) Evaluation of patients referred for percutaneous ablation of renal tumors: importance of a preprocedural diagnosis. AJR Am J Roentgenol 183:575–582

    PubMed  Google Scholar 

  37. Matsumoto ED, Watumull L, Johnson DB, Ogan K, Taylor GD, Josephs S, Cadeddu JA (2004) The radiographic evolution of radio frequency ablated renal tumors. J Urol 172:45–48

    Article  PubMed  Google Scholar 

  38. McGovern FJ, Goldberg SN, Wood BJ, Mueller PR (1999) Radiofrequency ablation of renal cell carcinoma via image-guided needle electrodes. J Urol 161:599–600

    Article  PubMed  CAS  Google Scholar 

  39. Lotan Y Cadeddu JA (2005) A cost comparison of nephron-sparing surgical techniques for renal tumour. BJU Int 95:1039–1042

    Article  PubMed  Google Scholar 

  40. Rhim H, Dodd GD, Chintapalli KN, Wood BJ, Dupuy DE, Hvizda JL, Sewell PE, Goldberg SN (2004) Radiofrequency thermal ablation of abdominal tumors: lessons learned from complications. Radiographics 24:41–52

    PubMed  Google Scholar 

  41. Mayo-Smith WW, Dupuy DE, Parikh PM, Pezzullo JA, Cronan JJ (2003) Imaging-guided percutaneous radiofrequency ablation of solid renal masses: techniques and outcomes of 38 treatment sessions in 32 consecutive patients. AJR Am J Roentgenol 180:1503–1508

    PubMed  Google Scholar 

  42. Lee JM, Kim SW, Chung GH, Lee SY, Han YM, Kim CS (2003) Open radio-frequency thermal ablation of renal VX2 tumors in a rabbit model using a cooled-tip electrode: feasibility, safety, and effectiveness. Eur Radiol 13:1324–1332

    Article  PubMed  Google Scholar 

  43. Michaels MJ, Rhee HK, Mourtzinos AP, Summerhayes IC, Silverman ML, Libertino JA (2002) Incomplete renal tumor destruction using radio frequency interstitial ablation. J Urol 168:2406–2410

    Article  PubMed  Google Scholar 

  44. Rendon RA, Kachura JR, Sweet JM, Gertner MR, Sherar MD, Robinette M, Trachtenberg JTJ, Sampson H, Jewett MAS (2002) The uncertainty of radiofrequency treatment of renal cell carcinoma: findings at immediate and delayed nephrectomy. J Urol 167:1587–1592

    Article  PubMed  Google Scholar 

  45. Walther MM, Shawker TH, Libutti SK, Lubensky I, Choyke PL, Venzon D, Linehan WM (2000) A phase 2 study of radio frequency interstitial tissue ablation of localized renal tumors. J Urol 163:1424–1427

    Article  PubMed  CAS  Google Scholar 

  46. Jacomides L, Ogan K, Watumull L, Cadeddu JA (2003) Laparoscopic application of radio frequency energy enables in situ renal tumor ablation and partial nephrectomy. J Urol 169:49–53

    Article  PubMed  Google Scholar 

  47. Uchida M, Imaide Y, Sugimoto K, Uehara H, Watanabe H (1995) Percutaneous cryosurgery for renal tumors. Br J Urol 75:132–136

    Article  PubMed  CAS  Google Scholar 

  48. Hoffmann NE, Bischof JC (2002) The cryobiology of cryosurgical injury. Urology 60[2 Suppl 1]:40–49

    Article  PubMed  Google Scholar 

  49. Stephenson RA, King DK, Rohr LR (1996) Renal cryoablation in a canine model. Urology 47:772–776

    Article  PubMed  CAS  Google Scholar 

  50. Nadler RB, Kim SC, Rubenstein JN, Yap RL, Campbell SC, User HM (2003) Laparoscopic renal cryosurgery: the northwestern experience. J Urol 170:1121–1125

    Article  PubMed  Google Scholar 

  51. Korshandi M, Foy RC, Chong W, Hoenig D, Cohen JK, Rukstalis DB (2002) Preliminary experience with cryoablation of renal lesions smaller than 4 centimeters. J Am Osteopath Assoc 102:277–281

    Google Scholar 

  52. Shingleton WB, Sewell PE (2001) Percutaneous renal tumor cryoablation with MRI guidance. J Urol 165:773–776

    Article  PubMed  CAS  Google Scholar 

  53. Harada J, Dohi M, Mogami T (2001) Initial experience of percutaneous renal cryosurgery under the guidance of horizontal open MRI system. Radiat Med 19:291–296

    PubMed  CAS  Google Scholar 

  54. Lofti MA, McCue P, Gomella LG (1994) Laparoscopic interstitial contact laser ablation of renal lesions: an experimental model. J Endourol 8:153–156

    Article  Google Scholar 

  55. Dick EA, Joarder R, De Jode MG, Wragg P, Vale JA, Gedroyc WM (2002) Magnetic resonance imaging-guided laser thermal ablation of renal tumours. BJU Int 90:814–822

    Article  PubMed  CAS  Google Scholar 

  56. De Jode MG, Vale JA, Gedroyc WM (1999) MRguided laser thermoablation of inoperable renal tumors in an open-configuration interventional MR scanner: preliminary clinical experience in three cases. J Magn Reson Imaging 10:545–549

    Article  PubMed  Google Scholar 

  57. Hirao Y, Fujimoto K, Yoshii M, Tanaka N, Hayashi Y, Momose H, Samma S, Okajima E, Uemura H, Yoshida K, Ozono S (2002) Non-ischemic nephron-sparing surgery for small renal cell carcinoma: complete tumor enucleation using a microwave tissue coagulator. Jpn J Clin Oncol 32:95–102

    Article  PubMed  Google Scholar 

  58. Murota T, Kawakita M, Oguchi N, Shimada O, Danno S, Fujita I, Matsuda T (2002) Retroperitoneoscopic partial nephrectomy using microwave coagulation for small renal tumors. Eur Urol 41:540–545

    Article  PubMed  Google Scholar 

  59. Paterson RF, Barret E, Siqueira TM Jr, Gardner TA, Tavakkoli J, Rao VV, Sanghvi NT, Cheng L, Shalhav AL (2003) Laparoscopic partial kidney ablation with high intensity focused ultrasound. J Urol 169:347–351

    Article  PubMed  Google Scholar 

  60. Susani M, Madersbacher S, Kratzik C, Vingers L, Marberger M (1993) Morphology of tissue destruction induced by focused ultrasound. Eur Urol 23:34–38

    PubMed  Google Scholar 

  61. Kohrmann KU, Michel MS, Gaa J, Marlinghaus E, Alken P (2002) High intensity focused ultrasound as noninvasive therapy for multilocal renal cell carcinoma: case study and review of the literature. J Urol 167:2397–2403

    Article  PubMed  Google Scholar 

  62. Wu F, Wang ZB, Chen WZ, Bai J, Zhu H, Qiao TY (2003) Preliminary experience using high intensity focused ultrasound for the treatment of patients with advanced stage renal malignancy. J Urol 170:2237–2240

    Article  PubMed  Google Scholar 

  63. Ogan K, Jacomides L, Dolmatch BL, Rivera FJ, Dellaria MF, Josephs SC, Cadeddu JA (2002) Percutaneous radiofrequency ablation of renal tumors: technique, limitations, and morbidity. Urology 60:954–958

    Article  PubMed  Google Scholar 

  64. Matlaga BR, Zagoria RJ, Woodruff RD, Torti FM, Hall MC (2002) Phase II trial of radio frequency ablation of renal cancer: evaluation of the kill zone. J Urol 168:2401–2405

    Article  PubMed  Google Scholar 

  65. Pavlovich CP, Walther MM, Choyke PL, Pautler SE, Chang R, Linehan WM, Wood BJ (2002) Percutaneous radio frequency ablation of small renal tumors: initial results. J Urol 167:10–15

    Article  PubMed  Google Scholar 

  66. De Baere T, Kuoch V, Smayra T, Dromain C, Cabrera T, Court B, Roche A (2002) Radiofrequency ablation of renal cell carcinoma: preliminary clinical experience. Urology 167:1961–1964

    Article  Google Scholar 

  67. Roy-Choudhury SH, Cast JE, Lee-Elliott CE, Breen DJ (2002) Percutaneous radiofrequency (RFA) ablation of small renal cell carcinoma (RCC) — medium-term outcome (abstract). Radiology 225:S387

    Google Scholar 

  68. Su LM, Jarrett TW, Chan DY, Kavoussi LR, Solomon SB (2003) Percutaneous computed tomography-guided radiofrequency ablation of renal masses in high surgical risk patients: preliminary results. Urology 61[Suppl 4A]:26–33

    Article  PubMed  Google Scholar 

  69. Farrell MA, Charboneau WJ, DiMarco DS, Chow GK, Zincke H, Callstrom MR, Lewis BD, Lee RA, Reading CC (2003) Imaging-guided radiofrequency ablation of solid renal tumors. AJR Am J Roentgenol 180:1509–1513

    PubMed  CAS  Google Scholar 

  70. Lewin JS, Nour SG, Connell CF, Sulman A, Duerk JL, Resnick MI, Haaga JR (2004) Phase II clinical trial of interactive MR imaging-guided interstitial radiofrequency thermal ablation of primary kidney tumors: initial experience. Radiology 232:835–845

    PubMed  Google Scholar 

  71. Zagoria RJ, Hawkins AD, Clark PE, Hall MC, Matlaga BR, Dyer RB, Chen MY (2004) Percutaneous CT-guided radiofrequency ablation of renal neoplasms: factors influencing success. AJR Am J Roentgenol 183:201–207

    PubMed  Google Scholar 

  72. Veltri A, De Fazio G, Malfitana V, Isolato G, Fontana D, Tizzani A, Gandini G (2004) Percutaneous US-guided RF thermal ablation for malignant renal tumors: preliminary results in 13 patients. Eur Radiol 14:2303–2310

    Article  PubMed  Google Scholar 

  73. Chiou YY, Hwang JI, Chou YH, Wang JH, Chiang JH, Chang CY (2005) Percutaneous radiofrequency ablation of renal cell carcinoma. J Chin Med Assoc 68:221–225

    Article  PubMed  Google Scholar 

  74. Matsumoto ED, Johnson DB, Ogan K, Trimmer C, Sagalowsky A, Margulis V, Cadeddu JA (2005) Short-term efficacy of temperature-based radiofrequency ablation of small renal tumors. Urology 65:877–881

    Article  PubMed  Google Scholar 

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  1. Department of Diagnostic Radiology, University Hospital, RWTH Aachen University, Pauwelsstraße 30, 52074, Aachen, Germany

    Dr. med. Andreas Mahnken

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  1. Dr. med. Andreas Mahnken
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  2. Joseph Tacke
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  1. Departement of Diagnostic Radiology, Faculty of Medicine Carl Gustav Carus University Hospital, Fetscherstrasse 74, 01377, Dresden, Germany

    Christian Stroszczynski

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Mahnken, A., Tacke, J. (2006). Renal Tumors. In: Stroszczynski, C. (eds) Minimally Invasive Tumor Therapies. Recent Results in Cancer Research, vol 167. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-28137-1_9

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  • DOI: https://doi.org/10.1007/3-540-28137-1_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-28136-8

  • Online ISBN: 978-3-540-28137-5

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