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Inhibitory Ly49 Receptors on Mouse Natural Killer Cells

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Negative Co-Receptors and Ligands

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 350))

Abstract

The Ly49 receptors, which are expressed in a stochastic manner on subsets of murine natural killer (NK) cells, T cells, and other cells, are encoded by the Klra gene family and include receptors with either inhibitory or activating function. All of the inhibitory Ly49 receptors are characterized by an immunoreceptor tyrosine-based inhibitory motif in their cytoplasmic domain, which upon phosphorylation recruits tyrosine or lipid phosphatases to dampen signals transmitted through other activating receptors. Most of the inhibitory Ly49 receptors recognize polymorphic epitopes on major histocompatibility complex (MHC) class I proteins as ligands. Here, we review the polymorphism, ligand specificity, and signaling capacity of the inhibitory Ly49 receptors and discuss how these molecules regulate NK cell development and function.

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Acknowledgments

M.T.O. is an Irvington Postdoctoral Fellow of the Cancer Research Institute. L.L.L. is a American Cancer Society Professor and is supported by NIH grants AI068129, CA095137, and AI066897. The authors have no competing financial interests.

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Authors and Affiliations

  1. Department of Microbiology and Immunology and the Cancer Research Institute, University of California, San Francisco, CA, 94143, USA

    Mark T. Orr & Lewis L. Lanier

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  1. Mark T. Orr
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  2. Lewis L. Lanier
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Correspondence to Mark T. Orr or Lewis L. Lanier .

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Editors and Affiliations

  1. Emory Vaccine Center &, Yerkes National Primate Research Center, Emory University, Gatewood Rd. 954, Atlanta, 30329, Georgia, USA

    Rafi Ahmed

  2. Fac. Medicine, Dept. Medical Chemistry and Molecular, Kyoto University, Yoshida Konoe-cho, Kyoto, 606-8501, Japan

    Tasuku Honjo

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Orr, M.T., Lanier, L.L. (2010). Inhibitory Ly49 Receptors on Mouse Natural Killer Cells. In: Ahmed, R., Honjo, T. (eds) Negative Co-Receptors and Ligands. Current Topics in Microbiology and Immunology, vol 350. Springer, Berlin, Heidelberg. https://doi.org/10.1007/82_2010_85

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