DNA replication is a fundamental process within the cell cycle. The exact duplication of the genetic information ensures genome stability. Extensive research has identified the principal players required for the sequential processes: originlicensing (a controlled order of events giving a chromosome site the potential to be initiated within the S phase of the same cell cycle); initiation (by removing the license a previous licensed site is transformed into a site where the DNA helix starts to melt); and DNA replication (copying the parental DNA by leading and lagging strand DNA-synthesis). The present report compares the advantages and limitations of studying DNA replication in the model systems Xenopus laevis (X. laevis) and in Simian Virus 40 (SV40).
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Oehlmann, M., Mahon, C., Nasheuer, HP. (2007). Comparison of DNA Replication in Xenopus laevis and Simian Virus 40. In: Fagagna, F.d.d., Chiocca, S., McBlane, F., Cavallaro, U. (eds) Advances in Molecular Oncology. Advances In Experimental Medicine And Biology, vol 604. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-69116-9_1
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DOI: https://doi.org/10.1007/978-0-387-69116-9_1
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