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Mechanisms of Metastasis: Seed and Soil

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Cancer Metastasis And The Lymphovascular System: Basis For Rational Therapy

Part of the book series: Cancer Treatment and Research ((CTAR,volume 135))

Stephen Paget published in 1889 in The Lancet a paper by the title of “The distribution of secondary growths in cancer of the breast” inspired by the work of Fuchs “Das Sarkom des Uvealtractus” in 1882 published in Graefe’s Archiv Fur Ophthalmologie. Although Fuchs has written previously about the metastatic embolus and its relationship to the recipient tissue, it is Paget who spread the concept of the “seed and soil” that continues to be regarded as a major contribution to the area of cancer metastasis.The “seeds” refer to certain tumor cells with metastatic capability, and the “soil” is any organ or tissue providing a proper environment for growth of the seeds (1). Paget suggested that the spread of metastatic cells was organ specific and not merely anatomic.

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Authors and Affiliations

  1. Department of Dermatopathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA

    Adriano Piris MD & Martin C. Mihm MD

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  1. Adriano Piris MD
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  2. Martin C. Mihm MD
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Editors and Affiliations

  1. University of California San Francisco and UCSF Comprehensive Cancer Center at Mount Zion, 1600 Divisadero Street, 94143, San Francisco, CA, USA

    Stanley P. L. Leong MD, FACS

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Piris, A., Mihm, M.C. (2007). Mechanisms of Metastasis: Seed and Soil. In: Leong, S.P.L. (eds) Cancer Metastasis And The Lymphovascular System: Basis For Rational Therapy. Cancer Treatment and Research, vol 135. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-69219-7_9

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  • DOI: https://doi.org/10.1007/978-0-387-69219-7_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-0-387-69218-0

  • Online ISBN: 978-0-387-69219-7

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