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Precursors of Vulvovaginal Squamous Cell Carcinoma

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Pathology of the Vulva and Vagina

Part of the book series: Essentials of Diagnostic Gynecological Pathology ((EDGP))

Abstract

The current classification of intraepithelial lesions of the vulva defines two distinct types of vulvar intraepithelial neoplasia (VIN), termed usual-type VIN (uVIN) and differentiated-type VIN (dVIN). uVIN occurs in younger women, is typically associated with high-risk HPV infection and hence with neoplasia at other anogenital sites. Vaginal intraepithelial neoplasia (VaIN) is also strongly related to HPV infection and is classified morphologically in a similar way to uVIN. Associated carcinomas are generally of warty or basaloid type. By contrast, dVIN occurs in older women, is not typically associated with HPV infection but rather shows a clinicopathological association with lichen sclerosus and HPV-negative keratinizing squamous cell carcinoma. This chapter describes these entities, highlighting the role played by HPV infection in the development of uVIN and VaIN, and discusses whether HPV-associated and non-HPV-associated VIN lesions equate to uVIN and dVIN, respectively.

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Authors and Affiliations

  1. Department of Pathology, Ninewells Hospital, Dundee, DD1 9SY, UK

    Richard Oparka BMSc, MBChB

  2. Department of Pathology, Ninewells Hospital and Division of Cancer Research, Jacqui Wood Cancer Centre, University of Dundee, James Arrott Drive, DD1 9SY, UK

    C. Simon Herrington MA., MBBS, DPhil, FRCP, FRCPath

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  1. Richard Oparka BMSc, MBChB
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  2. C. Simon Herrington MA., MBBS, DPhil, FRCP, FRCPath
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Correspondence to C. Simon Herrington MA., MBBS, DPhil, FRCP, FRCPath .

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  1. , Department of Pathology, Leicester Royal Infirmary, Infirmary Square, Leicester, LE1 5WW, United Kingdom

    Laurence Brown

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Oparka, R., Herrington, C.S. (2013). Precursors of Vulvovaginal Squamous Cell Carcinoma. In: Brown, L. (eds) Pathology of the Vulva and Vagina. Essentials of Diagnostic Gynecological Pathology. Springer, London. https://doi.org/10.1007/978-0-85729-757-0_6

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  • DOI: https://doi.org/10.1007/978-0-85729-757-0_6

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