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Synapse: A Clinical Trial Examining the Impact of Actively Engaging the Aging Mind

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Enhancing Cognitive Fitness in Adults

Abstract

A fundamental challenge and responsibility for modern science is to progress toward understanding neuroprotective factors that will support and optimize cognitive aging. The present chapter describes the scientifically driven efforts of our research group to this end. We do this in three ways beginning with a review of the latest findings regarding the neurocognitive declines that are part of the normal aging process. Next, we present the Scaffolding Theory of Aging and Cognition (STAC; Annu Rev Psychol 60:173–196, 2009), which describes a model for how the brain adapts to the neural deterioration that occurs as a natural part of the aging process. Finally, we introduce a program of research designed using the tenets of the STAC model to investigate how engaging in cognitively and socially stimulating activities may promote the neurocognitive health of seniors long term.

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References

  • Banich, M. T. (1998). The missing link: The role of interhemispheric interaction in attentional processing. Brain and Cognition, 36, 128–157.

    Article  PubMed  CAS  Google Scholar 

  • Basak, C., Boot, W. R., Voss, M. W., & Kramer, A. F. (2008). Can training in a real-time strategy video game attenuate cognitive decline in older adults? Psychology and Aging, 23, 765–777.

    Article  PubMed  Google Scholar 

  • Bennett, D. A., Wilson, R. S., Schneider, J. A., Evans, D. A., Leon, C. F. M. D., Arnold, S. E., et al. (2003). Education modifies the relation of AD pathology to level of cognitive function in older persons. Neurology, 60, 1909–1915.

    PubMed  CAS  Google Scholar 

  • Boot, W., & Blakely, D. (2011). Mental and physical exercise as a means to reverse cognitive aging and enhance well-being. In P. E. Hartman-Stein & A. La Rue (Eds.), Enhancing cognitive fitness in adults: A guide for use and development of community-based programs. New York: Springer.

    Google Scholar 

  • Bosma, H., Boxtel, M. P. V., Ponds, R. W., Houx, P. J., Burdorf, A., & Jolles, J. (2003). Mental work demands protect against cognitive impairment: MAAS prospective cohort study. Experimental Aging Research, 29, 33–45.

    Article  PubMed  Google Scholar 

  • Boyke, J., Driemeyer, J., Gaser, C., Buchel, C., & May, A. (2008). Training-induced brain structure changes in the elderly. The Journal of Neuroscience, 28, 7031–7035.

    Article  PubMed  CAS  Google Scholar 

  • Cabeza, R., Anderson, N. D., Locantore, J. K., & McIntosh, A. R. (2002). Aging gracefully: Compensatory brain activity in high-performing older adults. NeuroImage, 17, 1394–1402.

    Article  PubMed  Google Scholar 

  • Cabeza, R., Daselaar, S. M., Dolcos, F., Prince, S. E., Budde, M., & Nyberg, L. (2004). Task-independent and task-specific age effects on brain activity during working memory, visual attention and episodic retrieval. Cerebral Cortex, 14, 364–375.

    Article  PubMed  Google Scholar 

  • Cabeza, R., Grady, C. L., Nyberg, L., McIntosh, A. R., Tulving, E., Kapur, S., et al. (1997). Age-related differences in neural activity during memory encoding and retrieval: A positron emission tomography study. The Journal of Neuroscience, 17, 391–400.

    PubMed  CAS  Google Scholar 

  • Carlson, M. C., Erickson, K. I., Kramer, A. F., Voss, M. W., Bolea, N., Mielke, M., et al. (2009). Evidence for neurocognitive plasticity in at-risk older adults: The Experience Corps Program. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 64, 1275–1282.

    Article  Google Scholar 

  • Cherry, B. J., Adamson, M., Duclos, A., & Hellige, J. B. (2005). Aging and individual variation in interhemispheric collaboration and hemispheric asymmetry. Aging, Neuropsychology, and Cognition, 12, 316–339.

    Article  Google Scholar 

  • Colcombe, S., & Kramer, A. F. (2003). Fitness effects on the cognitive function of older adults. Psychological Science, 14, 125.

    Article  PubMed  Google Scholar 

  • Epstein, R., & Kanwisher, N. (1998). A cortical representation of the local visual environment. Nature, 392, 598–601.

    Article  PubMed  CAS  Google Scholar 

  • Fera, F., Weickert, T. W., Goldberg, T. E., Tessitore, A., Hariri, A., Das, S., et al. (2005). Neural mechanisms underlying probabilistic category learning in normal aging. The Journal of Neuroscience, 25, 11340–11348.

    Article  PubMed  CAS  Google Scholar 

  • Fjell, A. M., Westlye, L. T., Amlien, I., Espeseth, T., Reinvang, I., Raz, N., et al. (2009). High consistency of regional cortical thinning in aging across multiple samples. Cerebral Cortex, 19(9), 2001–2012.

    Article  PubMed  Google Scholar 

  • Gaser, C., & Schlaug, G. (2003). Brain structures differ between musicians and non-musicians. Journal of Neuroscience, 23, 9240.

    PubMed  CAS  Google Scholar 

  • Grady, C. L., McIntosh, A. R., Rajah, M. N., Beig, S., & Craik, F. I. (1999). The effects of age on the neural correlates of episodic encoding. Cerebral Cortex, 9, 805–814.

    Article  PubMed  CAS  Google Scholar 

  • Gutchess, A. H., Welsh, R. C., Hedden, T., Bangert, A., Minear, M., Liu, L. L., et al. (2005). Aging and the neural correlates of successful picture encoding: Frontal activations compensate for decreased medial-temporal activity. Journal of Cognitive Neuroscience, 17, 84–96.

    Article  PubMed  Google Scholar 

  • Head, D., Buckner, R. L., Shimony, J. S., Williams, L. E., Akbudak, E., Conturo, T. E., et al. (2004). Differential vulnerability of anterior white matter in nondemented aging with minimal acceleration in dementia of the Alzheimer type: Evidence from diffusion tensor imaging. Cerebral Cortex, 14, 410–423.

    Article  PubMed  Google Scholar 

  • Hillary, F. G., Genova, H. M., Chiaravalloti, N. D., Rypma, B., & DeLuca, J. (2006). Prefrontal modulation of working memory performance in brain injury and disease. Human Brain Mapping, 27, 837–847.

    Article  PubMed  Google Scholar 

  • Hultsch, D. F., Hertzog, C., Dixon, R. A., & Small, B. J. (1999). Memory changes in the aged. Cambridge: Cambridge University Press.

    Google Scholar 

  • Jessberger, S., & Gage, F. H. (2008). Stem-cell-associated structural and functional plasticity in the aging hippocampus. Psychology and Aging, 23, 684–691.

    Article  PubMed  Google Scholar 

  • Kanwisher, N., McDermott, J., & Chun, M. M. (1997). The fusiform face area: A module in human extrastriate cortex specialized for face perception. The Journal of Neuroscience, 17, 4302–4311.

    PubMed  CAS  Google Scholar 

  • Kempermann, G., Gast, D., & Gage, F. H. (2002). Neuroplasticity in old age: Sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment. Annals of Neurology, 52, 135–143.

    Article  PubMed  Google Scholar 

  • Kempermann, G., Kuhn, H. G., & Gage, F. H. (1998). Experience-induced neurogenesis in the senescent dentate gyrus. The Journal of Neuroscience, 18, 3206–3212.

    PubMed  CAS  Google Scholar 

  • Kobayashi, S., Ohashi, Y., & Ando, S. (2002). Effects of enriched environments with different durations and starting times on learning capacity during aging in rats assessed by a refined procedure of the Hebb-Williams maze task. Journal of Neuroscience Research, 70, 340–346.

    Article  PubMed  CAS  Google Scholar 

  • Lodi-Smith, J., Geise, A. C., Roberts, B. W., & Robins, R. W. (2009). Narrating personality change. Journal of Personality and Social Psychology, 96, 679–689.

    Article  PubMed  Google Scholar 

  • Lodi-Smith, J., & Roberts, B. W. (2007). Social investment and personality: A meta-analysis of the relationship of personality traits to investment in work, family, religion, and volunteerism. Personality and Social Psychology Review, 11, 68–86.

    Article  PubMed  Google Scholar 

  • Lustig, C., Shah, P., Seidler, R., & Reuter-Lorenz, P. A. (2009). Aging, training, and the brain: A review and future directions. Neuropsychology Review, 19, 504–522.

    Article  PubMed  Google Scholar 

  • Maguire, E. A., Gadian, D. G., Johnsrude, I. S., Good, C. D., Ashburner, J., Frackowiak, R. S., et al. (2000). Navigation-related structural change in the hippocampi of taxi drivers. Proceedings of the National Academy of Sciences of the United States of America, 97, 4398–4403.

    Article  PubMed  CAS  Google Scholar 

  • McCrae, R. R., & Costa, P. T. (1988). Age, personality, and the spontaneous self-concept. Journal of Gerontology, 43, S177–S185.

    PubMed  CAS  Google Scholar 

  • Morcom, A. M., Good, C. D., Frackowiak, R. S., & Rugg, M. D. (2003). Age effects on the neural correlates of successful memory encoding. Brain: A Journal of Neurology, 126, 213–229.

    Google Scholar 

  • Noice, H., Noice, T., & Staines, G. (2004). A short-term intervention to enhance cognitive and affective functioning in older adults. Journal of Aging and Health, 16, 562.

    Article  PubMed  Google Scholar 

  • Park, D. C., & Gutchess, A. H. (2005). Long-term memory and aging: A cognitive neuroscience perspective. In R. Cabeza, L. Nyberg, & D. C. Park (Eds.), Cognitive neuroscience of aging: Linking cognitive and cerebral aging (pp. 218–245). New York: Oxford Press.

    Google Scholar 

  • Park, D. C., Lautenschlager, G., Hedden, T., Davidson, N. S., Smith, A. D., & Smith, P. K. (2002). Models of visuospatial and verbal memory across the adult life span. Psychology and Aging, 17, 299–320.

    Article  PubMed  Google Scholar 

  • Park, D. C., Polk, T. A., Park, R., Minear, M., Savage, A., & Smith, M. R. (2004). Aging reduces neural specialization in ventral visual cortex. Proceedings of the National Academy of Sciences of the United States of America, 101, 13091–13095.

    Article  PubMed  CAS  Google Scholar 

  • Park, D. C., & Reuter-Lorenz, P. A. (2009). The adaptive brain: Aging and neurocognitive scaffolding. Annual Review of Psychology, 60, 173–196.

    Article  PubMed  Google Scholar 

  • Pereira, A. C., Huddleston, D. E., Brickman, A. M., Sosunov, A. A., Hen, R., McKhann, G. M., et al. (2007). An in vivo correlate of exercise-induced neurogenesis in the adult dentate gyrus. Proceedings of the National Academy of Sciences, 104, 5638–5643.

    Article  CAS  Google Scholar 

  • Persson, J., Nyberg, L., Lind, J., Larsson, A., Nilsson, L. G., Ingvar, M., et al. (2006). Structure-function correlates of cognitive decline in aging. Cerebral Cortex, 16, 907–915.

    Article  PubMed  Google Scholar 

  • Polk, T. A., & Farah, M. J. (1998). The neural development and organization of letter recognition: Evidence from functional neuroimaging, computational modeling, and behavioral studies. Proceedings of the National Academy of Sciences of the United States of America, 95, 847–852.

    Article  PubMed  CAS  Google Scholar 

  • Polk, T. A., Stallcup, M., Aguirre, G. K., Alsop, D. C., D’Esposito, M., Detre, J. A., et al. (2002). Neural specialization for letter recognition. Journal of Cognitive Neuroscience, 14, 145–159.

    Article  PubMed  Google Scholar 

  • Potkanowicz, E. S. (2011). The role of physical activity in cognitive fitness: a general guide for community programs. In P. E. Hartman-Stein & A. La Rue (Eds.), Enhancing cognitive fitness in adults: A guide for use and development of community-based programs. New York: Springer.

    Google Scholar 

  • Puce, A., Allison, T., Asgari, M., Gore, J. C., & McCarthy, G. (1996). Differential sensitivity of human visual cortex to faces, letter strings, and textures: A functional magnetic resonance imaging study. The Journal of Neuroscience, 16, 5205–5215.

    PubMed  CAS  Google Scholar 

  • Raz, N. (2000). Aging of the brain and its impact on cognitive performance: Integration of structural and functional findings. In F. Craik & T. A. Salthouse (Eds.), The handbook of aging and cognition (2nd ed., pp. 1–90). New York: Psychology Press.

    Google Scholar 

  • Raz, N., & Kennedy, K. M. (2009). A systems approach to age-related change: Neuroanatomical changes, their modifiers, and cognitive correlates. In W. Jagust & M. D’Esposito (Eds.), Imaging the aging brain (pp. 151–268). New York: Oxford University Press.

    Google Scholar 

  • Raz, N., Rodrigue, K. M., Head, D., Kennedy, K. M., & Acker, J. D. (2004). Differential aging of the medial temporal lobe: A study of a five-year change. Neurology, 62, 433–438.

    PubMed  CAS  Google Scholar 

  • Rebok, G. W., Carlson, M. C., Barron, J. S., Frick, K. D., McGill, S., & Parisi, J. M. (2011). Experience Corps®: A civic engagement-based public health intervention in the public schools. In P. E. Hartman-Stein & A. La Rue (Eds.), Enhancing cognitive fitness in adults: A guide for use and development of community-based programs. New York: Springer.

    Google Scholar 

  • Reuter-Lorenz, P. A., & Cappell, K. (2008). Neurocognitive aging and the compensation hypothesis. Current Directions in Psychological Science, 18, 177–182.

    Article  Google Scholar 

  • Reuter-Lorenz, P. A., Jonides, J., Smith, E. E., Hartley, A., Miller, A., Marshuetz, C., et al. (2000). Age differences in the frontal lateralization of verbal and spatial working memory revealed by PET. Journal of Cognitive Neuroscience, 12, 174–187.

    Article  PubMed  CAS  Google Scholar 

  • Reuter-Lorenz, P. A., Marshuetz, C., Jonides, J., Smith, E. E., Hartley, A., & Koeppe, R. (2001). Neurocognitive ageing of storage and executive processes. The European Journal of Cognitive Psychology, 13, 257.

    Google Scholar 

  • Reuter-Lorenz, P. A., Stanczak, L., & Miller, A. (1999). Neural recruitment and cognitive aging: Two hemispheres are better than one especially as you age. Psychological Science, 10, 494–500.

    Article  Google Scholar 

  • Roberts, B. W., Wood, D., & Smith, J. L. (2005). Evaluating Five Factor Theory and social investment perspectives on personality trait development. Journal of Research in Personality, 39, 166–184.

    Article  Google Scholar 

  • Rypma, B., & D’Esposito, M. (2001). Age-related changes in brain–behaviour relationships: Evidence from event-related functional MRI studies. The European Journal of Cognitive Psychology, 13, 235.

    Article  Google Scholar 

  • Salat, D. H., Buckner, R. L., Snyder, A. Z., Greve, D. N., Desikan, R. S., Busa, E., et al. (2004). Thinning of the cerebral cortex in aging. Cerebral Cortex, 14, 721–730.

    Article  PubMed  Google Scholar 

  • Schooler, C., Mulatu, M. S., & Oates, G. (1999). The continuing effects of substantively complex work on the intellectual functioning of older workers. Psychology and Aging, 14, 483–506.

    Article  PubMed  CAS  Google Scholar 

  • Stine-Morrow, E. A. L., & Parisi, J. M. (2011). A practical guide to senior Odyssey. In P. E. Hartman-Stein & A. La Rue (Eds.), Enhancing cognitive fitness in adults: A guide for use and development of community-based programs. New York: Springer.

    Google Scholar 

  • Wen, W., & Sachdev, P. (2004). The topography of white matter hyperintensities on brain MRI in healthy 60- to 64-year-old individuals. NeuroImage, 22, 144–154.

    Article  PubMed  Google Scholar 

  • Wilson, R. S., & Bennett, D. A. (2003). Cognitive activity and risk of Alzheimer’s disease. Current Directions in Psychological Science, 12, 87.

    Article  Google Scholar 

  • Wilson, R. S., Bennett, D. A., Gilley, D. W., Beckett, L. A., Barnes, L. L., & Evans, D. A. (2000). Premorbid reading activity and patterns of cognitive decline in Alzheimer disease. Archives of Neurology, 57, 1718–1723.

    Article  PubMed  CAS  Google Scholar 

  • Zhou, X., & Merzenich, M. M. (2007). Intensive training in adults refines A1 representations degraded in an early postnatal critical period. Proceedings of the National Academy of Sciences of the United States of America, 104, 15935–15940.

    Article  PubMed  CAS  Google Scholar 

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Acknowledgments

Research supported by the National Institutes on Aging grants #R01AG026589 and 1RC1AG036003.

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Authors and Affiliations

  1. Department of Psychology, Canisius College, 2001 Main Street, Buffalo, NY, 14208, USA

    Jennifer Lodi-Smith Ph.D.

  2. Center for Vital Longevity, University of Texas, Dallas, TX, USA

    Denise C. Park Ph.D.

Authors
  1. Jennifer Lodi-Smith Ph.D.
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  2. Denise C. Park Ph.D.
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Corresponding author

Correspondence to Jennifer Lodi-Smith Ph.D. .

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Editors and Affiliations

  1. Center for Healthy Aging, W. Main St. 265, Kent, 44240-2403, Ohio, USA

    Paula E. Hartman-Stein

  2. School of Medicine & Public Health, Wisconsin Alzheimer's Institute, University of Wisconsin, Big Sky Drive 7818, Madison, 53719, Wisconsin, USA

    Asenath LaRue

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Lodi-Smith, J., Park, D.C. (2011). Synapse: A Clinical Trial Examining the Impact of Actively Engaging the Aging Mind. In: Hartman-Stein, P., LaRue, A. (eds) Enhancing Cognitive Fitness in Adults. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0636-6_4

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  • DOI: https://doi.org/10.1007/978-1-4419-0636-6_4

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