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Shift Work and Circadian Disruption

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Breast Cancer Epidemiology

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Abstract

There is increasing interest in the possible role of environmental factors that can alter normal endocrine function, often referred to as “endocrine disruptors,” in the etiology of cancer. Because the release of nearly all hormones exhibits a circadian timing patterned on approximately a 24-h cycle, agents that disrupt circadian rhythm may also alter endocrine function and thereby the regulation of reproductive hormones (Czeisler and Klerman 1999). Of particular interest regarding breast cancer is the potential influence of both light at night and sleep disruption on the regulation of estrogen release and levels of circulating estrogen.

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Authors and Affiliations

  1. Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA

    Scott Davis & Dana K. Mirick

  2. Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, WA, USA

    Scott Davis

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  1. Scott Davis
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  2. Dana K. Mirick
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Correspondence to Scott Davis .

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    Christopher Li

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Davis, S., Mirick, D.K. (2010). Shift Work and Circadian Disruption. In: Li, C. (eds) Breast Cancer Epidemiology. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-0685-4_10

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