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Signaling Pathways Involved in NCAM-Induced Neurite Outgrowth

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Structure and Function of the Neural Cell Adhesion Molecule NCAM

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 663))

Abstract

The neural cell adhesion molecule, NCAM, plays important roles in both the developing and adult brains. NCAM, originally, was described as a homophilic cell adhesion molecule abundantly expressed in the central nervous system. This view has been challenged, however, during the last two decades, and NCAM now is considered to be an inducer of complex intracellular signaling cascades in response to extracellular cues. Homo and heterophilic NCAM interactions result in the induction of neurite outgrowth, neuronal survival, and astrocyte proliferation. Here, we review the available data regarding NCAM-induced intracellular signaling and focus on the most intensively studied cellular response, neurite outgrowth.

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Authors and Affiliations

  1. Protein Laboratory, Institute of Neuroscience and Pharmacology, University of Copenhagen, Panum Institute, Building 6.2, Blegdamsvej 3, 2200, Copenhagen, Denmark

    Dorte Kornerup Ditlevsen & Kateryna Kolkova

  2. Enkam Pharmaceuticals A/S, Fruebjergvej 3, 582100, Copenhagen, Denmark

    Dorte Kornerup Ditlevsen & Kateryna Kolkova

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  1. Dorte Kornerup Ditlevsen
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  2. Kateryna Kolkova
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Correspondence to Dorte Kornerup Ditlevsen .

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  1. Panum Institute, Dept. Regenerative Medicine, University of Copenhagen, Blegdamsvej 3C, Koebenhavn N, 2200, Denmark

    Vladimir Berezin

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Ditlevsen, D.K., Kolkova, K. (2010). Signaling Pathways Involved in NCAM-Induced Neurite Outgrowth. In: Berezin, V. (eds) Structure and Function of the Neural Cell Adhesion Molecule NCAM. Advances in Experimental Medicine and Biology, vol 663. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1170-4_10

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