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The Role of ATP in the Regulation of NCAM Function

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Structure and Function of the Neural Cell Adhesion Molecule NCAM

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 663))

Abstract

Extracellular ATP is an abundant signaling molecule that has a number of functions in the nervous system. It is released by both neurons and glial cells, activates purinergic receptors, and acts as a trophic factor as well as a neurotransmitter. In this review, we summarize the evidence for a direct ATP-NCAM interaction and discuss its functional implications. The ectodomain of NCAM contains the ATP binding Walker motif A and has intrinsic ATPase activity, which could modulate NCAM-dependent signaling processes. NCAM interacts directly with and signals through FGFR. The NCAM binding site to ATP overlaps with the site of NCAM-FGFR interaction, and ATP is capable of disrupting NCAM-FGFR binding. This implies that NCAM signaling through FGFR can be regulated by ATP, which is supported by the observation that ATP can abrogate NCAM-induced neurite outgrowth. Finally, ATP can induce NCAM ectodomain shedding, possibly affecting the structural plasticity associated with learning and memory.

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Authors and Affiliations

  1. Department of Cellular and Molecular Medicine, University of Copenhagen, The Panum Institute building 12.6, Blegdamsvej 3, 2200, Copenhagen N, Denmark

    Martin V. Hübschmann

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  1. Martin V. Hübschmann
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  2. Galina Skladchikova
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Correspondence to Martin V. Hübschmann .

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  1. Panum Institute, Dept. Regenerative Medicine, University of Copenhagen, Blegdamsvej 3C, Koebenhavn N, 2200, Denmark

    Vladimir Berezin

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Hübschmann, M.V., Skladchikova, G. (2010). The Role of ATP in the Regulation of NCAM Function. In: Berezin, V. (eds) Structure and Function of the Neural Cell Adhesion Molecule NCAM. Advances in Experimental Medicine and Biology, vol 663. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-1170-4_5

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