Skip to main content

Basic Physiology of Pain Perception

  • Chapter
Pathophysiology of Pain Perception

Part of the book series: Plenum Series in Rehabilitation and Health ((SSRH))

Abstract

In science, pain is the subject of biology, medicine, psychology and the social sciences. As a result, a bio-psycho-social perspective has been increasingly on the rise in medical science. In this article I will address the neurobiological mechanisms of pain, while endeavoring to approach the issue from an interdisciplinary standpoint.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Beck, P. W., Handwerker, H. O., & Zimmermann, M. (1974). Nervous outflow from the cat’s foot during noxious radiant heat stimulations. Brain Research, 67, 373–386.

    Article  PubMed  Google Scholar 

  • Borsook, D. (Ed.) (1997). Molecular Neurobiology of Pain. Seattle: 1ASP Press.

    Google Scholar 

  • Carstens, E., Klumpp, D., & Zimmermann, M. (1980). Differential inhibitory effects of medial and lateral midbrain stimulation on spinal neuronal discharges to noxious skin heating in the cat. Journal of Neurophysiology, 43, 322–342.

    Google Scholar 

  • Coderre, T. J., Katz, J., Vaccarino, A. L., & Melzack, R. (1993). Contribution of central plasticity to pathological pain: review of clinical and experimental evidence. Pain, 52, 259–285.

    Article  PubMed  Google Scholar 

  • Dubuisson, D., & Dennis, S. G. (1977). The formalin test: a quantitative study of the analgesic effects of morphine, meperidinc, and brain stem stimulation in rats and cats. Pain, 4, 161–174.

    Article  PubMed  Google Scholar 

  • Fields, H. L., & Basbaum, A. I. (1994). Central nervous system mechanisms of pain modulation. In P. D. Wall & R. Melzack (Eds.), Textbook of Pain, 3rd Edition (pp. 243–257). Edinburgh: Churchill Livingstone.

    Google Scholar 

  • Foerster, O. (1927). Die Leitungsbahnen des Schmerzgefühls und die chirurgische Behandlung der Schmervgustände. Berlin, Wien: Urban & Schwarzenberg.

    Google Scholar 

  • Gebhardt, G. F. (1996). Visceral polymodal nociceptors.In T. Kumazawa, L. Kruger & K. Mizumura (Eds.), The Polymodal Receptor: A Gateway to Pathological Pain (pp. 101–114). Amsterdam: Elsevier.

    Chapter  Google Scholar 

  • Gebhardt, G. F., Sandkühler, J., Thalhammer, J.G., & Zimmermann, M. (1984). Inhibition in spinal cord of nociceptive information by electrical stimulation and morphine microinjection at identical sites in midbrain of the cat. Journal of Neurophysiology, 51, 75–89.

    Google Scholar 

  • Gillardon, F., Beck, H., Uhlmann, E., Herdegen, T., Sandkühler, J., Peymann, A., & Zimmermann, M. (1994). Inhibition of c-Fos protein expression in rat spinal cord by antisense oligodeoxynucleotide superfusion. European Journal of Neuroscience, 6, 880–884.

    Article  PubMed  Google Scholar 

  • Handwerker, H.O. (1999). Einführung in die Pathophysiologie des Schmerzes. Heidelberg: Springer.

    Book  Google Scholar 

  • Handwerker, H. O., Iggo, A., & Zimmermann, M. (1975). Segmental and supra-spinal actions on dorsal horn neurons responding to noxious and non-noxious skin stimuli. Pain, 1, 147–165.

    Article  PubMed  Google Scholar 

  • Hansen, K., & Schliack, H. (1962). Segmentale Inmrvation. Stuttgart: Thieme.

    Google Scholar 

  • Hassler, R. (1960). Die zentralen Systeme des Schmerzes. Acta Neurochirurgica, 8, 353–423.

    Article  PubMed  Google Scholar 

  • Hsieh, J. C., Stahle-Backdahl, M., Hagermark, O., Stone-Elander, S., Rosenquist, G., & Ingvar, M. (1996). Traumatic nociceptive pain activates the hypothalamus and the periaqueductal gray: a positron emission tomography study. Pain, 64, 303–314.

    Article  PubMed  Google Scholar 

  • Ji, R.-R., & Woolf, C. J. (2001). Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain. Neurobiology of Disease 8, 1–10.

    Article  PubMed  Google Scholar 

  • Maggi, C. A., & Meli, A (1988). The sensory-efferent function of capsaicin-sensitive neurons. General Pharmacology 19, 1–43.

    PubMed  Google Scholar 

  • MacLean, P. D. (1990). The triune brain. Role in paleocerebral functions. Plenum, New York.

    Google Scholar 

  • Mense, S. (1993). Nociception from skeletal muscle in relation to clinical muscle pain. Pain, 54, 241–289.

    Article  PubMed  Google Scholar 

  • Morgan, J. I., & Curran, T. (1989). Stimulus-transcription coupling in neurons: role of cellular immediate-early genes. Trends in Neurosciences, 12, 459–462.

    Article  PubMed  Google Scholar 

  • Nieuwenhuys, R. (1985). Chemoarchitecture of the brain. Berlin, Springer.

    Book  Google Scholar 

  • Reynolds, D.V. (1969). Surgery in the rat during electrical analgesia induced by focal brain stimulation. Science, 164, 444–445.

    Article  PubMed  Google Scholar 

  • Sandkühler, J., Bromm, B., & Gebhart, G. F. (Eds.) (2000). Progress in Brain Research, Vol. 129. Amsterdam: Elsevier Science.

    Google Scholar 

  • Schmidt, R. F., Schaible, H.-G., Meßlinger, K., Heppelmann, B., Hanesch, U., & Pawlak, M. (1994). Silent and active nociceptors: structure, functions, and clinical implications. In G. F. Gebhart, D. L. Hammond & D. S. Jensen (Eds.), Proceedings of the 7th World Congress on Pain. Progress in Pain Research and Management, vol 2 (pp. 213–250), Seattle: IASP Press.

    Google Scholar 

  • Tölle, T. R., Schadrack, J., & Zieglgänsberger, W. (Eds.) (1995). Immediate-Early Genes in the Central Nervous System. Berlin: Springer.

    Google Scholar 

  • Tricklebank, M. D., & Curzon, G. (Eds.) (1984). Stress Induced Analgesia. New York: Wiley.

    Google Scholar 

  • Willis, W. D. (1982). Control of nociceptive transmission in the spinal cord. In H. Autrum, G. Ottoson, E. R. Pert & R. E Schmidt (Eds.), Progress in Sensory Physiology, vol 3. Berlin, Heidelberg, New York, Tokyo: Springer.

    Google Scholar 

  • Zimmermann, M. (1983). Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16, 109–110.

    Article  PubMed  Google Scholar 

  • Zimmermann, M. (1991). Central nervous mechanisms modulating pain-related information: do they become deficient after lesions of the peripheral or central nervous system? In K. L. Casey (Ed.), Pain and Central Nervous System Disease: the Central Pain Syndromes (pp. 183–199). New York: Raven Press.

    Google Scholar 

  • Zimmermann, M. (2001). Pathobiology of neuropathic pain. European Journal of Pharmacology, 429, 23–37.

    Article  PubMed  Google Scholar 

  • Zimmermann, M., & Herdegen, T. (1996). Plasticity of the nervous system at the systemic, cellular and molecular levels: A mechanism of chronic pain and hyperalgesia. In G. Carli & M. Zimmermann (Eds.), Towards the Neurobiology of Chronic Pain. Progress in Brain Research, vol 110 (pp. 233–259). Amsterdam: Elsevier.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2004 Springer Science+Business Media New York

About this chapter

Cite this chapter

Zimmermann, M. (2004). Basic Physiology of Pain Perception. In: Lautenbacher, S., Fillingim, R.B. (eds) Pathophysiology of Pain Perception. Plenum Series in Rehabilitation and Health. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-9068-6_1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4419-9068-6_1

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4613-4780-4

  • Online ISBN: 978-1-4419-9068-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics