Abstract
As in many surgical specialties, much of the tissue which is excised in an ophthalmic operating theatre is not submitted to pathological examination. The common operations such as cataract extraction, corneal graft (keratoplasty), glaucoma surgery (trabeculectomy) and extraocular muscle shortening (squint or strabismus surgery) yield specimens which show tissue changes that are considered by some clinicians to be irrelevant to the further management of the patient, although the material is certainly of value in research institutes. By contrast, an informed opinion is always required for the investigation of inflammatory or neoplastic disease of the globes, the eyelids, the conjunctiva or the orbit, and such diagnostic histopathology is well within the remit of an experienced general pathologist.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bergua A, Jünmann A, Naumann GOH (1993) NADPH-D-reaktive choroidale Ganglienzellen beim Menschen. Klin Monatsbl Augenheilkd 203:77–82
Damji KF, Allingham RR (1997) Molecular genetics is revolutionising our understanding of ophthalmic disease. Am J Ophthalmol 124: 530–543
Della NG (1996) Molecular biology in ophthalmology. A review of principles and recent advances. Arch Ophthalmol 114:457–463
Dixon JS, Jen PYP, Gosling JA (1998) Immunohistochemical characteristics of human paraganglion cells and sensory corpuscles associated with the urinary bladder. A developmental study in the male fetus, neonate and infant. J Anat 192:407–415
Evans AT, Orrell JM, Grant A (1991) Re-evaluating silver-stained nucleolar organizer regions (AGNORs) in problematic cutaneous melanocytic lesions: a study with quantitation and pattern analysis. J Pathol 65:61–67
Freeman WR Wiley CA (1989) In situ nucleic acid hybridization. Sury Ophthalmol 34:187–192
Glasgow BJ, Foos RY (1993) Ocular Cytopathology. Butterworth Heinemann, Boston
Green WR (1984) Diagnostic cytopathology of ocular fluid specimens. Ophthalmology 91:726–749
Grossniklaus HE (1992) Fine needle aspiration biopsy of the iris. Arch Ophthalmol 110:969–976
Karcioglu ZA, Caldwell DR (1984) Frozen section diagnosis in ophthalmic surgery. Sury Ophthalmol 28:323–332
Khalil AK, Kubota T, Tawara A, Inomata H (1996) Ultrastructural agerelated changes on the posterior iris surface. A possible relationship to the pathogenesis of exfoliation. Arch Ophthalmol 114:721–725
Lalani EN, Golding M, Hudson M (1995) Protein extraction and western blotting from methacarn-fixed tissue. J Pathol 177:323–328
Latchman DS (Editor) (1995) PCR Applications in Pathology. Principles and Practice. Oxford University Press, Oxford
Laver NM, Robison G, Pfeffer BA (1993) Novel procedure for isolating intact retinal vascular beds from diabetic humans and animal models. Invest Ophthalmol Vis Sci 34:2097–2104
Leong S-Y (Editor) (1993) Applied Immunohistochemistry for the Surgical Pathologist. Edward Arnold, London McMenamin PG (1997) The distribution of immune cells in the uveal tract of the normal eye. Eye 11:183–193
McNicol AM, Farquharson MA (1997) In situ hybridization and its diagnostic applications in pathology. J Pathol 182:250–261
Marcus DM, Minkovitz JB, Wardwell SD, Albert DM (1990) The value of nucleolar organizer regions in uveal melanoma. Am J Ophthalmol 110:527–534
Margo CE (1986) Special histochemical stains in ocular pathology. Sury Ophthalmol 31:131–135
Margo CE, Lee A (1995) Fixation of whole eyes: the role of fixative osmolarity in the production of tissue artefact. Graefes Arch Clin Exp Ophthalmol 233:355–370
Marshall GE, Konstas AG, Lee WR (1993) Collagens in ocular tissue. Br J Ophthalmol 77:515–524
Mies C (1994) Molecular biological analysis of paraffin-embedded tissues. Hum Pathol 25:555–560
Müller LJ, Pels L, Vrensen GFJM (1996) Ultrastructural organisation of human corneal nerves. Invest Ophthalmol Vis Sci 37:476–478
Olver JM, McCartney ACE (1989) Anterior segment vascular casting. Eye 3:303–307
Pellegrini G, Traverso CE, Franzi AT, Zingrian M, Cancedda R, De Luca M (1997) Long term restoration of damaged corneal surfaces with autologous cultivated corneal epithelium. Lancet 349:990–993
Polak JM, McGhee JOD (1990) In Situ Hybridisation. Principles and Practice. Oxford University Press, Oxford
Polak JM, van Noorden S (1983) Immunocytochemistry. Practical Applications in Pathology and Biology. Wright PSG, Bristol
Rummelt V, Wenkel H, Rummelt C, Jahn G, Meyer HJ, Naumann GOH (1992) Detection of varicella zoster virus DNA and viral antigen in the late stage of bilateral acute retinal necrosis syndrome. Arch Ophthalmol 110:1132–1136
Ruskell G (1998) The retinopial vein: a vein passing directly from the retina to the pia mater at the optic nerve head. Br J Ophthalmol 82:495–497
Sharpe RW, Bethel KJ, Keefe KS, Hall FW, Levine EM, Regillo CD (1996) Choroidal haematopoiesis in an adult. Arch Ophthalmol 114: 1421–1422
Stanton CA, Sloan B, Slusher MM, Greven CM (1992) Acquired immunodeficiency syndrome-related primary intraocular lymphoma. Arch Ophthalmol 110:1614–1617
Taylor AW, Sehu KW, Lee WR, Williamson TW (1993) Morphometric assessment of the central retinal artery and vein in the optic nerve head. Can J Ophthalmol 28: 320–324
Wilkerson CL, Syed NA, Fisher MR, Robinson NL, Wallow IHL, Albert DM (1996) Melanocytes and iris colour. Arch Ophthalmol 114: 437–442
Wilson DJ, Braziel R, Rosenbaum JT (1992) Intraocular lymphoma. Immunopathologic analysis of vitreous biopsy specimens. Arch Ophthalmol 110:1455–1458
Wilson MW, Czechonska G, Finger PT, Rausen A, Hooper ME, Haik BG (2001) Chemotherapy for eye cancer. Sury Ophthalmol 45:416–444
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer-Verlag London
About this chapter
Cite this chapter
Lee, W.R. (2002). Examination of the Globe. Technical Aspects. In: Ophthalmic Histopathology. Springer, London. https://doi.org/10.1007/978-1-4471-3910-2_1
Download citation
DOI: https://doi.org/10.1007/978-1-4471-3910-2_1
Publisher Name: Springer, London
Print ISBN: 978-1-4471-3912-6
Online ISBN: 978-1-4471-3910-2
eBook Packages: Springer Book Archive