Abstract
One of the few known causes of sarcomas is therapeutic irradiation. Therapeutic radiation has also been associated with development of breast cancer, lung cancer, and accelerated coronary artery disease in patients receiving thoracic radiation [1, 2]. With the increased recognition of second cancers as a long-term side effect of radiation therapy, some attempts have been made to use radiation more sparingly; however, for reasons unclear to the authors, use of therapeutic radiation is even more widespread than in the past, with the use of tylectomy and radiation therapy, a recognized standard of care for ductal carcinoma in situ of the breast, despite the ability to obtain negative margins in at least 95 % of patients with surgery alone [3, 4]. The incidence of a sarcoma after radiation is not precisely known and may vary from one part of the body to the next. In a series of patients treated for cancer of all sites in Finland, for example, the crude risk was of the order of 0.05 % [5].
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Brennan, M.F., Antonescu, C.R., Maki, R.G. (2013). Radiation-Induced Sarcomas. In: Management of Soft Tissue Sarcoma. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-5004-7_16
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DOI: https://doi.org/10.1007/978-1-4614-5004-7_16
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