Abstract
Glial cell line-derived neurotrophic factor (GDNF) and related neurotrophic factors neurturin (NRTN), artemin (ARTN) and persephin (PSPN) form a subgroup in the transforming growth factor-β superfamily. They signal by binding to a receptor complex consisting of a ligand-binding GPI-anchored GDNF family receptor a (GFRα1 to GFRα4) and the trans-membrane tyrosine kinase Ret (for review see references 1–3). A schematic view of the GDNF family signaling is shown in Fig. 1.
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Rossi, J., Airaksinen, M.S. (2002). GDNF Family Signalling in Exocrine Tissues: Distinct Roles for GDNF and Neurturin in Parasympathetic Neuron Development. In: Sullivan, D.A., Stern, M.E., Tsubota, K., Dartt, D.A., Sullivan, R.M., Bromberg, B.B. (eds) Lacrimal Gland, Tear Film, and Dry Eye Syndromes 3. Advances in Experimental Medicine and Biology, vol 506. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-0717-8_2
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DOI: https://doi.org/10.1007/978-1-4615-0717-8_2
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