Abstract
The efficiency of hormonal stimulation on metabolic regulation not only depends on the plasma concentration of the hormones, their receptors, post-receptor, and second messenger systems, but also on the enzymatic and metabolic adaptation triggered by physical activity. Insulin and catecholamines, as well as the mechanisms, which elicit the metabolic response, will be discussed. The previous assumption of the insulin mediated glucose transport through the cell membrane after insulin receptor interaction and post-receptor activation is challenged by the function of the glucose transporter Glut 4 on the plasma and intracellular membranes. New findings on this subject, such as additive effects of insulin and exercise, will be reported. The exercise induced catecholamine overflow, which can exceed resting values by up to 50 fold, is attenuated by adrenoreceptor down-regulation, post-receptor adaptation, activation of second messenger systems, metabolic and renal clearance rates, as well as by the sulfconjugation of catecholamines. The metabolic regulation of carbohydrate-and lipid metabolism by insulin and catecholamines will be addressed.
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References
Bonen, A., J. C. McDermott, and M. H. Tan. Glucose transport in skeletal muscle. Intern. Series On Sport Sciences: Biochemistry of Exercise VII, 21: 295–317, 1990.
Cryer, P. E. Physiology and pathophysiology of the human sympathoadrenal neuroendocrine system. New Engl. J. Med. 303: 436–443, 1980.
Czech, M. P. The nature and regulation of the insulin receptor: structure and function. Ann. Rev. Physiol. 47:357–381, 1985.
Etgen Jr., G. J., A. R. Memon, G. A. Thompson Jr., and J. L. Ivy. Insulin-and contraction-stimulated translocation of GTP binding proteins and Glut 4 protein in skeletal muscle. J. Biol. Chem. 268: 20164–20169, 1993.
Farrell, P. A. Exercise effects on regulation of energy metabolism by pancreatic and gut hormones. Perspectives in Exerc. Science and Sports Med.: Energy Supply in Exercise and Sport 5: 383–434, 1992.
Flores-Riveros, J. R., K. H. Kästner, K. S. Thompson, and M. D. Lane. Cyclic AMP-induced transcriptional repression of the insulin-responsive glucose transporter (Glut 4) gene: identification of a promoter region required for down-regulation of transcription. Biochem. Biophys. Res. Commun. 194: 1148–1154, 1993.
Goodyear, L. J., M. F. Hirshman, P. M. Valyou, and E. S. Horton. Glucose transporter number, function, and subcellular distribution in rat skeletal muscle after exercise training. Diabet. 41: 1091–1099, 1992.
Hausdorff, W. P., M. G. Caron, and R. J. Lefkowitz. Turning off the signal: desensitization of beta-adrenergic receptor function. FASEB J. 4: 2881–2889. 1990.
Herrmann-Frank, A., and G. Meissner. Regulation of Ca 2+ release from skeletal muscle sarcoplasmatic reticulum. Muscle Fatigue Mechan. in Exerc. and Train. 34: 11–19, 1992.
Jakobs, D. B., and Y. C. Jung. Sulfonylurea potentiates insulin-induced recruitment of glucose transport carrier in rat adipocytes. J.. Biol. Chem. 260: 2593–2596. 1985.
Kono, T., F. W. Robinson, T. L. Blevins, and O. Ezaki. Evidence that translocation of the glucose transporter acitivity is the major mechanism of insulin action on glucose transport in fat cells. J. Biol. Chem. 18: 10942–10947, 1982.
Neufer, P. D., M. H. Shinebarger, and G. L. Dohm. Effect of training and detraining on skeletal glucose transporter (Glut 4) content in rats. Can. J. Physiol. and Pharmacol. 70: 1286–1290, 1992.
Piper, R. C., D. E. James, J.W. Slot, C. Puri, and J. C. Lawrence Jr. Glut 4 phosphorylation and inhibition of glucose transport by dibutyryl cAMP. J. Biol. Chem. 268: 16557–16563, 1993.
Ploug, T., H. Galbo, and E. A. Richter. Increased muscle glucose uptake during concentrations: no need for insulin. Am. J. Physiol. 247: E726–E731, 1984.
Ploug, T., H. Galbo, J. Vinten, M. Jorgensen. and E. A. Richter. Kinetics of glucose transport in rat muscle: effects of insulin and concentrations. Am. J. Physiol. 253: E12–E20, 1987.
Richter, E. A., T. Ploug, and H. Galbo. Increased muscle glucose uptake after exercise. Diabet. 34: 1041–1048, 1985.
Rodnick, K. J., E. J. Henriksen, D. E. James, and J. O. Holloszy. Exercise training, glucose transporters, and glucose transport in rat skeletal muscles. Am. J. Physiol. 262: C9–C14, 1992.
Rosen, O. M. After Insulin Binds. Science 237: 1452–1458, 1987.
Slentz, C. A., E. A. Gulve, K. J. Rodnick, E. J. Henriksen, J. H. Youn, and J. O. Holloszy. Glucose transporters and maximal transport are increased in endurance trained rat soleus. Am. J. Physiol. 73: 486–492, 1992.
Smith, R. L., and J. C. Lawrence Jr. Insulin action in denervated skeletal muscle. J.. Biol. Chem. 260: 273–278, 1985.
Strobel, G., B. Friedmann, J. Jost, and P. Bärtsch. Plasma and platelet catecholamine and catecholamine sulfate response to various exercise tests. Am. J. Physiol. 267: E537–E543, 1994.
Weicker, H., G. Strobel. Sportmedizin:Biochemisch-physiologische Grundlagen und ihre sportartspezifische Bedeutung. Stuttgart, Germany: Gustav Fischer Verlag, Stuttgart, 1994.
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Weicker, H., Strobel, G. (1996). Endocrine Regulation of Metabolism During Exercise. In: Steinacker, J.M., Ward, S.A. (eds) The Physiology and Pathophysiology of Exercise Tolerance. Springer, Boston, MA. https://doi.org/10.1007/978-1-4615-5887-3_16
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DOI: https://doi.org/10.1007/978-1-4615-5887-3_16
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