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Axon Guidance Factors in Developmental and Pathological Angiogenesis

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Endothelial Signaling in Development and Disease

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Abstract

Despite the defined and crucial roles of classical angiogenic proteins such as vascular endothelial growth factor (VEGF), Notch, and angiopoietins in the vascular system, recent research shows that the sophisticated and multistep processes of vascular growth, guidance, and stability also require the participation of different molecular families that were first identified to have a role in the nervous system. This chapter will therefore focus on the canonical axon guidance cues netrins, slits, semaphorins, and ephrins, and summarize the current knowledge regarding their role in the vascular system during health and disease.

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Acknowledgements

This work is supported by the European Research Council (ERC-StG-2012; 311367 NeuroVascular Link).

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  1. Biochemistry Center, Heidelberg University, Im Neuenheimer Feld 328, 69120, Heidelberg, Germany

    Robert Luck MSc & Carmen Ruiz de Almodovar PhD

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    Mirko HH Schmidt

  2. Institute of Neurology Building 89, 4.Floor, R402, Goethe University Frankfurt School of Medicine, Frankfurt, Germany

    Stefan Liebner

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Luck, R., Ruiz de Almodovar, C. (2015). Axon Guidance Factors in Developmental and Pathological Angiogenesis. In: Schmidt, M., Liebner, S. (eds) Endothelial Signaling in Development and Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2907-8_11

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