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Vascular Development in the Zebrafish

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Endothelial Signaling in Development and Disease

Abstract

One of the earliest processes during vertebrate development is the formation of the cardiovascular system. This highly complex system of differently sized tubes permits circulation of blood while enabling the exchange of oxygen and nutrients in all perfused tissues. Recent studies in zebrafish have provided additional insight into the initial establishment of the vasculature, particularly the process of vasculogenesis. During vasculogenesis, angioblasts exhibit a complex migratory behavior before they differentiate into endothelial cells and form a primitive vascular network. In addition to migrating to specific locations, endothelial precursor cells also need to be specified to take on arterial and venous fates. In particular, the interdependence between the spatial and temporal localization of early angioblasts and their arterial-venous specification has gained some interest and is one focus of this review. Furthermore, we discuss the complex network of genetic interactions that play a role in arterial-venous specification.

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Abbreviations

DA:

Dorsal aorta

DLAV:

Dorsal longitudinal anastomotic vessel

HLT:

Hypotrichosis-lymphedema-telangiectasia

HMG:

High-mobility group

HPF:

Hours post-fertilization

ISV:

Intersegmental vessels

LDA:

Lateral dorsal aorta

LPM:

Lateral plate mesoderm

MO:

Morpholino

NICD:

Notch intracellular domain

PCV:

Posterior cardinal vein

PHBC:

Primordial hindbrain channel

TAD:

Transactivation domain

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Authors and Affiliations

  1. Cells-in-Motion Cluster of Excellence (EXC 1003—CiM), University of Münster, Münster, Germany

    Prof. Dr. Stefan Schulte-Merker PhD

  2. Hubrecht Institute—KNAW & UMC Utrecht, 3584 CT, Utrecht, The Netherlands

    Dorien M. A. Hermkens PhD & Prof. Dr. Stefan Schulte-Merker PhD

  3. Erasmus MC, Rotterdam, The Netherlands

    Dorien M. A. Hermkens PhD & Henricus J. Duckers MD, PhD

  4. Institute for Cardiovascular Organogenesis and Regeneration, WWU, Mendelstr. 7, 48149, Münster, Germany

    Prof. Dr. Stefan Schulte-Merker PhD

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  1. Dorien M. A. Hermkens PhD
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  2. Henricus J. Duckers MD, PhD
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  3. Prof. Dr. Stefan Schulte-Merker PhD
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Correspondence to Stefan Schulte-Merker PhD .

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  1. Microscopic Anatomy and Neurobiology Building 708, 2.Floor, R2.006, Johannes Gutenberg University School of Medicine, Mainz, Germany

    Mirko HH Schmidt

  2. Institute of Neurology Building 89, 4.Floor, R402, Goethe University Frankfurt School of Medicine, Frankfurt, Germany

    Stefan Liebner

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Hermkens, D., Duckers, H., Schulte-Merker, S. (2015). Vascular Development in the Zebrafish. In: Schmidt, M., Liebner, S. (eds) Endothelial Signaling in Development and Disease. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-2907-8_2

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