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MicroRNAs in Disease

  • Chapter
Genomic Elements in Health, Disease and Evolution

Abstract

MicroRNAs are short non-coding RNA species that serve as post-transcriptional regulators of mRNA expression and they have a pivotal role in all cellular functions. Recently, there has been a great interest in deciphering the role of miRNAs in human diseases with a growing possibility of exploiting miRNAs in therapy as well. A miRNA can either be the primary cause of a disease, or be directly or indirectly involved in developing a pathological phenotype. Furthermore, miRNAs have been implicated in complex genetic diseases, while many researchers attempt to build miRNA expression maps characterizing specific diseases. Such findings assist in the better understanding of miRNA functions, dissect the biological background of a disease, as well as become a springboard for the development or improvement of prognostic, diagnostic and therapeutic tools. This chapter aims in providing a concise description of how miRNAs are responsible in the developing pathology of human disease, as well as provide an overview of the workflow followed in miRNA studies.

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  1. Department of Biological Sciences, Molecular Medicine Research Center, University of Cyprus, 75 Kallipoleos Str., 1678, Nicosia, Cyprus

    Gregory Papagregoriou Ph.D.

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  1. Department of Life and Health Sciences and University of Nicosia Medical School, University of Nicosia, Nicosia, Cyprus

    Kyriacos Felekkis

  2. Department of Biological Sciences, Molecular Medicine Research Center, University of Cyprus, Nicosia, Cyprus

    Konstantinos Voskarides

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Papagregoriou, G. (2015). MicroRNAs in Disease. In: Felekkis, K., Voskarides, K. (eds) Genomic Elements in Health, Disease and Evolution. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-3070-8_2

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