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Immunoregulation in Experimental Autoimmune Endocrine Disease

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Autoimmune Endocrinopathies

Part of the book series: Contemporary Endocrinology ((COE,volume 15))

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Abstract

The proposition of Mackay and Burnet that failure of immune regulation is best envisaged as the central feature of autoimmune disease remains as relevant three decades later as it was in 1964. Nevertheless, views on the precise manner in which immune homeostasis is achieved have changed since then, accompanying changes in perception of the mechanisms mediating immune functions. It is likely that they will be subject to ongoing modification as understanding of the immune system is further refined.

Probably the most satisfactory way to look at autoimmune disease is as a failure at some point of the normal homeostatic mechanisms that prevent the emergence of forbidden clones (1).

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Authors
  1. Peter McCullagh MD, DPhil, MRCP
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Editors and Affiliations

  1. Division of Endocrinology, Department of Medicine, The Wellesley Hospital, University of Toronto, Toronto, Ontario, Canada

    Robert Volpé MD, FRCP(C), FACP, FRCP

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McCullagh, P. (1999). Immunoregulation in Experimental Autoimmune Endocrine Disease. In: Volpé, R. (eds) Autoimmune Endocrinopathies. Contemporary Endocrinology, vol 15. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-704-8_2

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  • DOI: https://doi.org/10.1007/978-1-59259-704-8_2

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4757-4572-6

  • Online ISBN: 978-1-59259-704-8

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