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Chemical Interaction of Nitric Oxide With Protein Thiols

S-Nitrosylation Signaling

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Signal Transduction and the Gasotransmitters

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Summary

Protein S-nitrosylation reactions signal physiological effects. These reactions are carefully regulated in cells under normal conditions to achieve specificity and to prevent nitrosative stress. This regulation is achieved through metabolic control of S-nitrosothiol (SNO) synthesis and catabolism, as well as through cellular localization. Conditions involving excessive SNO accumulation (i.e., nitrosative stress) and regional SNO depletion (i.e., asthma and cystic fibrosis) have been associated with the pathophysiology of specific diseases.

SNO signaling involves a covalent modification of protein thiolate groups and, as such, is distinctly different from NO signaling involving free-radical reactions with metal centers. The study of SNO signaling is a rapidly emerging discipline that is relevant to nearly every field of medicie. However, the field remains hampered by imprecise assays and biochemical controversies. This chapter reviews the bioactivities and metabolism of physiological SNO compounds as well as the interaction of these compounds with aasotransmitters.

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Authors
  1. Allan Doctor
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  2. Benjamin M. Gaston
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Editors and Affiliations

  1. Department of Physiology, University of Saskatchewan, Saskatoon, SK, Canada

    Rui Wang MD, PhD, FAHA

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Doctor, A., Gaston, B.M. (2004). Chemical Interaction of Nitric Oxide With Protein Thiols. In: Wang, R. (eds) Signal Transduction and the Gasotransmitters. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-59259-806-9_4

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  • DOI: https://doi.org/10.1007/978-1-59259-806-9_4

  • Publisher Name: Humana Press, Totowa, NJ

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