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Prognostic Indicators in Penile Cancer

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Textbook of Penile Cancer

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Abstract

Penile cancer prognosis is closely related to the natural history of the neoplasm. The primary cancer progressively infiltrates penile structures, initially in a horizontal and superficial pattern of spread, followed by a stepwise vertical invasion through the penile fascia and tunica albuginea1. However, the main characteristic of this uncommon malignancy is the high tendency to metastasize through the lymphatic vasculature to superficial inguinal, deep inguinal, and pelvic lymph nodes.

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References

  1. Velazquez EF, Soskin A, Bock A, Codas R, Barreto JE, Cubilla AL. Positive resection margins in partial penectomies: sites of involvement and proposal of local routes of spread of penile squamous cell carcinoma. Am J Surg Pathol. 2004;28:384-389.

    Article  PubMed  Google Scholar 

  2. Rippentrop JM, Joslyn SA, Konety BR. Squamous cell carcinoma of the penis: evaluation of data from the surveillance, epidemiology, and end results program. Cancer. 2004;101(6):1357-1363.

    Article  PubMed  Google Scholar 

  3. Hakenberg OW, Wirth MP. Issues in the treatment of penile carcinoma. A short review. Urol Int. 1999;62(4):229-233.

    Article  PubMed  CAS  Google Scholar 

  4. Ornellas AA, Seixas AL, Marota A, et al. Surgical treatment of invasive squamous cell carcinoma of the penis: retrospective analysis of 350 cases. J Urol. 1994;151(5):1244-1249.

    PubMed  CAS  Google Scholar 

  5. Horenblas S, van Tinteren H, Delemarre JF, et al. Squamous cell carcinoma of the penis. III. Treatment of regional lymph nodes. J Urol. 1993;149(3):492-497.

    PubMed  CAS  Google Scholar 

  6. Bouchot O, Auvigne J, Peuvrel P, et al. Management of regional lymph nodes in carcinoma of the penis. Eur Urol. 1989;16(6):410-415.

    PubMed  CAS  Google Scholar 

  7. Pizzocaro G, Piva L, Bandieramonte G, et al. Up-to-date management of carcinoma of the penis. Eur Urol. 1997;32(1):5-15.

    PubMed  CAS  Google Scholar 

  8. Ficarra V, Akduman B., Bouchot O., Palou J., Tobias-Machado M. Prognostic factors in penile cancer. In: Pompeo AC, Heyns CF, Abrams P, eds. Penile Cancer. International Consultation on Penile Cancer, Edition 2009.

    Google Scholar 

  9. Villavicencio H, Rubio-Briones J, Regalado R, et al. Grade, local stage and growth pattern as prognostic factors in carcinoma of the penis. Eur Urol. 1997;32(4):442-447.

    PubMed  CAS  Google Scholar 

  10. Bezerra AL, Lopes A, Santiago GH, et al. Human papillomavirus as a prognostic factor in carcinoma of the penis: analysis of 82 patients treated with amputation and bilateral lymphadenectomy. Cancer. 2001;91(12):2315-2321.

    Article  PubMed  CAS  Google Scholar 

  11. Novara G, Galfano A, De Marco V, et al. Prognostic factors in squamous cell carcinoma of the penis. Nat Clin Pract Urol. 2007;4(3):140-146.

    Article  PubMed  Google Scholar 

  12. Pandey D, Mahajan V, Kannan RR. Prognostic factors in node-positive carcinoma of the penis. J Surg Oncol. 2006;93(2):133-138.

    Article  PubMed  Google Scholar 

  13. Srinivas V, Morse MJ, Herr HW, et al. Penile cancer: relation of extent of nodal metastasis to survival. J Urol. 1987;137(5):880-882.

    PubMed  CAS  Google Scholar 

  14. Ravi R. Correlation between the extent of nodal involvement and survival following groin dissection for carcinoma of the penis. Br J Urol. 1993;72(5 Pt 2):817-819.

    Article  PubMed  CAS  Google Scholar 

  15. Leijte JA, Gallee M, Antonini N, Horenblas S. Evaluation of current TNM classification of penile carcinoma. J Urol. 2008;180:933-938.

    Article  PubMed  Google Scholar 

  16. Misra S, Chaturvedi A, Misra NC. Penile carcinoma: a challenge for the developing world. Lancet Oncol. 2004;5(4):240-247.

    Article  PubMed  Google Scholar 

  17. Ficarra V, Zattoni F, Cunico SC, et al. Gruppo Uro-Oncologico del Nord Est (Northeast Uro-Oncological Group) Penile Cancer Project. Lymphatic and vascular embolizations are independent predictive variables of inguinal lymph node involvement in patients with squamous cell carcinoma of the penis: Gruppo Uro-Oncologico del Nord Est (Northeast Uro-Oncological Group) Penile Cancer data base data. Cancer. 2005;103(12):2507-2516.

    Article  PubMed  Google Scholar 

  18. Leijte JA, Kirrander P, Antonini N, et al. Recurrence patterns of squamous cell carcinoma of the penis: recommendations for follow-up based on a two-centre analysis of 700 patients. Eur Urol. 2008;54(1):161-168.

    Article  PubMed  Google Scholar 

  19. Horenblas S. Lymphadenectomy for squamous cell carcinoma of the penis. Part 2: the role and technique of lymph node dissection. BJU Int. 2001;88(5):473-483.

    Article  PubMed  CAS  Google Scholar 

  20. Lopes A, Bezerra AL, Pinto CA, et al. p53 as a new prognostic factor for lymph node metastasis in penile carcinoma: analysis of 82 patients treated with amputation and bilateral lymphadenectomy. J Urol. 2002;168(1):81-86.

    Article  PubMed  Google Scholar 

  21. Guimarães GC, Lopes A, Campos RS, et al. Front pattern of invasion in squamous cell carcinoma of the penis: new prognostic factor for predicting risk of lymph node metastases. Urology. 2006;68(1):148-153.

    Article  PubMed  Google Scholar 

  22. Campos RS, Lopes A, Guimarães GC, et al. E-cadherin, MMP-2, and MMP-9 as prognostic markers in penile cancer: analysis of 125 patients. Urology. 2006;67(4):797-802.

    Article  PubMed  Google Scholar 

  23. Lopes A, Hidalgo GS, Kowalski LP, et al. Prognostic factors in carcinoma of the penis: multivariate analysis of 145 patients treated with amputation and lymphadenectomy. J Urol. 1996;156(5):1637-1642.

    Article  PubMed  CAS  Google Scholar 

  24. Lont AP, Kroon BK, Horenblas S, et al. Presence of high-risk human papillomavirus DNA in penile carcinoma predicts favorable outcome in survival. Int J Cancer. 2006;119(5):1078-1081.

    Article  PubMed  CAS  Google Scholar 

  25. Guimarães GC, Leal ML, Campos RS, et al. Do proliferating cell nuclear antigen and MIB-1/Ki-67 have prognostic value in penile squamous cell carcinoma? Urology. 2007;70(1):137-142.

    Article  PubMed  Google Scholar 

  26. Harmer MH. Penis (ICD-0187). In: TNM Classification of Malignant Tumours, 3rd ed. Geneva: International Union Against Cancer, pp. 126, 1978.

    Google Scholar 

  27. Horenblas S, van Tinteren H. Squamous cell carcinoma of the penis. IV. Prognostic factors of survival: analysis of tumor, nodes and metastasis classification system. J Urol. 1994;151(5):1239-1243.

    PubMed  CAS  Google Scholar 

  28. Guimaraes GC, Cunha IW, Soares FA, et al. Penile squamous cell carcinoma clinicopathological features, nodal metastasis and outcome in 333 cases. J Urol. 2009;182:528-534.

    Article  PubMed  Google Scholar 

  29. Dai B, Ye DW, Kong YY, et al. Predicting regional lymph node metastasis in Chinese patients with penile squamous cell carcinoma: the role of histopathological classification, tumor stage and depth of invasion. J Urol. 2006;176(4 Pt 1):1431-1435.

    Article  PubMed  Google Scholar 

  30. Broders AC. Squamous-cell epithelioma of the skin: a study of 256 cases. Ann Surg. 1921;73(2):141-160.

    Article  PubMed  CAS  Google Scholar 

  31. Slaton JW, Morgenstern N, Levy DA, et al. Tumor stage, vascular invasion and the percentage of poorly differentiated cancer: independent prognosticators for inguinal lymph node metastasis in penile squamous cancer. J Urol. 2001;165(4):1138-1142.

    Article  PubMed  CAS  Google Scholar 

  32. Ficarra V, Maffei N, Piacentini I, et al. Local treatment of penile squamous cell carcinoma. Urol Int. 2002;69(3):169-173.

    Article  PubMed  Google Scholar 

  33. Chaux A, Caballero C, Soares F, Guimaraes GC, Cunha IW, Reuter V, Barreto J, Rodriguez I, Cubilla AL. The prognostic index: a useful pathologic guide for prediction of nodal metastases and survival in penile squamous cell carcinoma. Am J Surg Pathol. 2009 Apr 18.

    Google Scholar 

  34. Cubilla AL, Barreto J, Caballero C, et al. Pathologic features of epidermoid carcinoma of the penis. A prospective study of 66 cases. Am J Surg Pathol. 1993;17(8):753-763.

    Article  PubMed  CAS  Google Scholar 

  35. Anneroth G, Batsakis J, Luna M. Review of the literature and a recommended system of malignancy grading in oral squamous cell carcinomas. Scand J Dent Res. 1987;95(3):229-249.

    PubMed  CAS  Google Scholar 

  36. Bryne M, Koppang HS, Lilleng R, et al. New malignancy grading is a better prognostic indicator than Broders’ grading in oral squamous cell carcinomas. J Oral Pathol Med. 1989;18(8):432-437.

    Article  PubMed  CAS  Google Scholar 

  37. Wiener JS, Effert PJ, Humphrey PA, et al. Prevalence of human papillomavirus types 16 and 18 in squamous-cell carcinoma of the penis: a retrospective analysis of primary and metastatic lesions by differential polymerase chain reaction. Int J Cancer. 1992;50(5):694-701.

    Article  PubMed  CAS  Google Scholar 

  38. Minhas S, Manseck A., Hegarty P., Watya S. Prevention and premalignant conditions. In: Pompeo AC, Heyns CF, Abrams P, Eds. Penile Cancer. International Consultation on Penile Cancer, Edition 2009.

    Google Scholar 

  39. Protzel C, Knoedel J, Zimmermann U, et al. Expression of proliferation marker Ki67 correlates to occurrence of metastasis and prognosis, histological subtypes and HPV DNA detection in penile carcinomas. Histol Histopathol. 2007;22(11):1197-1204.

    PubMed  CAS  Google Scholar 

  40. Solsona E, Iborra I, Ricós JV, et al. Corpus cavernosum invasion and tumor grade in the prediction of lymph node condition in penile carcinoma. Eur Urol. 1992;22(2):115-118.

    PubMed  CAS  Google Scholar 

  41. Solsona E, Iborra I, Rubio J, et al. Prospective validation of the association of local tumor stage and grade as a predictive factor for occult lymph node micrometastasis in patients with penile carcinoma and clinically negative inguinal lymph nodes. J Urol. 2001;165(5):1506-1509.

    Article  PubMed  CAS  Google Scholar 

  42. Solsona E, Algaba F, Horenblas S, et al. European Association of Urology. EAU Guidelines on Penile Cancer. Eur Urol. 2004;46(1):1-8.

    Article  PubMed  CAS  Google Scholar 

  43. Novara G, Artibani W, Cunico SC, et al. GUONE Penile Cancer Project. How accurately do Solsona and European Association of Urology risk groups predict for risk of lymph node metastases in patients with squamous cell carcinoma of the penis? Urology. 2008;71(2):328-333.

    Article  PubMed  Google Scholar 

  44. Ficarra V, Zattoni F, Artibani W, G.U.O.N.E. Penile Cancer Project Members, et al. Nomogram predictive of pathological inguinal lymph node involvement in patients with squamous cell carcinoma of the penis. J Urol. 2006;175(5):1700-1704.

    Article  PubMed  Google Scholar 

  45. Kattan MW, Ficarra V, Artibani W, et al. GUONE Penile Cancer Project Members. Nomogram predictive of cancer specific survival in patients undergoing partial or total amputation for squamous cell carcinoma of the penis. J Urol. 2006;175(6):2103-2108.

    Article  PubMed  Google Scholar 

  46. Bhagat SK, Gopolakrishnan G, Kekre NS, Chacko NK, Manipadam MT, Samuel P. Factors predicting inguinal node metastasis in squamous cell cancer of penis. World J Urol. 2009 Jun 2.

    Google Scholar 

  47. Heyns C, Fleshner N, Sangar V, Schlenker B, Thyavihally Y, van Poppel H. Management of the lymph nodes in penile cancer. In: Pompeo AC, Heyns CF, Abrams P, eds. Penile Cancer. International Consultation on Penile Cancer, Edition 2009.

    Google Scholar 

  48. Zhu Y, Zhou XY, Yao XD, et al. The prognostic significance of p53, Ki-67, epithelial cadherin and matrix metalloproteinase-9 in penile squamous cell carcinoma treated with surgery. BJU Int. 2007;100(1):204-208.

    Article  PubMed  CAS  Google Scholar 

  49. Behrens J, Mareel MM, Van Roy FM, et al. Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. J Cell Biol. 1989;108(6):2435-2447.

    Article  PubMed  CAS  Google Scholar 

  50. Egeblad M, Werb Z. New functions for the matrix metalloproteinases in cancer progression. Nat Rev Cancer. 2002;2(3):161-174.

    Article  PubMed  CAS  Google Scholar 

  51. Berdjis N, Meye A, Nippgen J, et al. Expression of Ki-67 in squamous cell carcinoma of the penis. BJU Int. 2005;96(1):146-148.

    Article  PubMed  CAS  Google Scholar 

  52. Dong JT, Lamb PW, Rinker-Schaeffer CW, et al. KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. Science. 1995;268(5212):884-886.

    Article  PubMed  CAS  Google Scholar 

  53. Son BH, Choi JS, Lee JH. Prognostic values of KAI1 and survivin expression in an infiltrating ductal carcinoma of the breast. Pathology. 2005;37(2):131-136.

    Article  PubMed  CAS  Google Scholar 

  54. Yang X, Wei L, Tang C, et al. KAI1 protein is down-regulated during the progression of human breast cancer. Clin Cancer Res. 2000;6(9):3424-3429.

    PubMed  CAS  Google Scholar 

  55. Zheng H, Tsuneyama K, Cheng C, et al. Expression of KAI1 and tenascin, and microvessel density are closely correlated with liver metastasis of gastrointestinal adenocarcinoma. J Clin Pathol. 2007;60(1):50-56.

    Article  PubMed  CAS  Google Scholar 

  56. Protzel C, Kakies C, Kleist B, et al. Down-regulation of the metastasis suppressor protein KAI1/CD82 correlates with occurrence of metastasis, prognosis and presence of HPV DNA in human penile squamous cell carcinoma. Virchows Arch. 2008;452(4):369-375.

    Article  PubMed  CAS  Google Scholar 

  57. Bhagat SK, Gopolakrishnan G, Kekre NS, Chacko NK, Manipadam MT, Samuel P. Factors predicting inguinal node metastasis in squamous cell cancer of penis. World J Urol. 2010;28(1):93-98.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Surgical and Oncological Sciences, Urologic Unit, University of Padua, Padua, Italy

    Vincenzo Ficarra M.D. & Giacomo Novara M.D.

  2. Department of Pathology, University of Verona, Verona, Italy

    Guido Martignoni M.D.

  3. Oncological and Surgical Sciences, Urology Clinic, University of Padua, Padua, Italy

    Filiberto Zattoni M.D.

Authors
  1. Vincenzo Ficarra M.D.
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  2. Giacomo Novara M.D.
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  3. Guido Martignoni M.D.
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  4. Filiberto Zattoni M.D.
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Editors and Affiliations

  1. Institute of Urology, Univeristy College London Hospitals, Euston Road, London, NW1 2PG, United Kingdom

    Asif Muneer

  2. University College London Hospital, Euston Road, London, N1W 2PG, United Kingdom

    Manit Arya

  3. Antoni van Leeuwenhoekhuis, Department of Urology, Netherlands Cancer Institute, Amsterdam, 1066 CX, Netherlands

    Simon Horenblas

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Ficarra, V., Novara, G., Martignoni, G., Zattoni, F. (2011). Prognostic Indicators in Penile Cancer. In: Muneer, A., Arya, M., Horenblas, S. (eds) Textbook of Penile Cancer. Springer, London. https://doi.org/10.1007/978-1-84882-879-7_10

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  • DOI: https://doi.org/10.1007/978-1-84882-879-7_10

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