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Myocardial Reperfusion Injury as a New Frontier for Clinical Therapy

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Management of Myocardial Reperfusion Injury

Abstract

Ischemic heart disease (IHD) is the leading cause of death and disability worldwide. A major manifestation of IHD is a ST-elevation myocardial infarction (STEMI), the optimal treatment for which is early myocardial reperfusion using primary percutaneous coronary intervention (PPCI). However, the process of myocardial reperfusion comes at a price, as restoring coronary blood flow to ischemic myocardium can in itself induce cardiomyocyte injury and death, a phenomenon which has been termed myocardial reperfusion injury. The presence of myocardial reperfusion injury mitigates the full benefits of PPCI in terms of myocardial salvage as it can be responsible for 40–50% of the infarct. Currently, there is no effective treatment for protecting the heart against myocardial reperfusion injury. Therefore, novel therapeutic strategies, which can be administered as adjuncts to PPCI and are capable of preventing myocardial reperfusion injury, are required to further limit infarct size, preserve left ventricular function and improve clinical outcomes in patients with IHD.

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Authors and Affiliations

  1. UCL Institute of Cardiovascular Science, The Hatter Cardiovascular Institute, University College London Hospital, 67 Chenies Mews, London, WC1E 6HX, UK

    Derek J. Hausenloy B.Sc., MBChB, MRCP, Ph.D. & Derek M. Yellon D.Sc., FESC, FACC

  2. Department of Clinical Sciences, Cardiovascular Sciences Research Centre, St. George’s, University of London, Cranmer Terrace, London, SW17 0RE, UK

    Juan Carlos Kaski DSc, DM(Hons), M.D., FRCP

  3. Division of Cardiovascular Diseases, Mayo Clinic, First Street SW, Rochester, 55902, MN, USA

    Bernard John Gersh MBChB, D.Phil., FRCP, Ph.D.

  4. Medicine Department, Mayo Clinic College of Medicine, Rochester, MN, USA

    Bernard John Gersh MBChB, D.Phil., FRCP, Ph.D.

Authors
  1. Derek J. Hausenloy B.Sc., MBChB, MRCP, Ph.D.
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  2. Juan Carlos Kaski DSc, DM(Hons), M.D., FRCP
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  3. Bernard John Gersh MBChB, D.Phil., FRCP, Ph.D.
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  4. Derek M. Yellon D.Sc., FESC, FACC
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Corresponding author

Correspondence to Derek J. Hausenloy B.Sc., MBChB, MRCP, Ph.D. .

Editor information

Editors and Affiliations

  1. Medical School, Coronary Artery Disease, Research Group, St George's Hospital, Cranmer Terrace, London, SW17 0RE, United Kingdom

    Juan Carlos Kaski

  2. Hatter Cardiovascular Inst., Div. Medicine, University College London, Chenies Mews 67, London, WC1E 6HX, United Kingdom

    Derek J. Hausenloy

  3. Mayo Graduate School of Medicine, Dept. Cardiovascular Diseases, Mayo Clinic, First Street SW. 200, Rochester, 55905, Minnesota, USA

    Bernard John Gersh

  4. Hatter Cardiovascular Institute, University College London, Chenies Mews 67, London, WC1E 6HX, United Kingdom

    Derek M. Yellon

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© 2012 Springer-Verlag London

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Hausenloy, D.J., Kaski, J.C., Gersh, B.J., Yellon, D.M. (2012). Myocardial Reperfusion Injury as a New Frontier for Clinical Therapy. In: Kaski, J., Hausenloy, D., Gersh, B., Yellon, D. (eds) Management of Myocardial Reperfusion Injury. Springer, London. https://doi.org/10.1007/978-1-84996-019-9_1

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  • DOI: https://doi.org/10.1007/978-1-84996-019-9_1

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  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84996-018-2

  • Online ISBN: 978-1-84996-019-9

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