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Pathophysiological Considerations Regarding Cluster Headache and Trigeminal Autonomic Cephalalgias

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Cluster Headache and other Trigeminal Autonomic Cephalgias

Part of the book series: Headache ((HEAD))

Abstract

When we discuss pathophysiological background regarding cluster headache, scientific progress over the last 20 years has put us in the fortunate situation that we can divide this question into “what drives cluster headache” and “where is the source of the pain.” For decades these (fundamentally different) questions have been mixed as so little was known about the pathophysiology of this dreadful disease. We have learned so much about modulators and generators of cluster headache attacks and—to be frank—know still relatively little of what structure actually generates the nociceptive input. We therefore focus here on central generating factors (the why) and refer to the Chaps. 8 and 9 in this book (the where) [1, 2].

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Authors and Affiliations

  1. Department of Neurology, Neuroalgology Unit, The Foundation of the Carlo Besta Neurological Institute, IRCCS, Milano, Italy

    Massimo Leone

  2. Department of Systems Neuroscience, University of Hamburg, Hamburg, Germany

    Arne May

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  1. Massimo Leone
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  2. Arne May
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Editors and Affiliations

  1. Department of Neurology, Neuroalgology Unit, The Foundation of the Carlo Besta Neurological Institute, IRCCS, Milano, Italy

    Massimo Leone

  2. Department of Systems Neuroscience, University of Hamburg, Hamburg, Germany

    Arne May

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Leone, M., May, A. (2020). Pathophysiological Considerations Regarding Cluster Headache and Trigeminal Autonomic Cephalalgias. In: Leone, M., May, A. (eds) Cluster Headache and other Trigeminal Autonomic Cephalgias. Headache. Springer, Cham. https://doi.org/10.1007/978-3-030-12438-0_6

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  • DOI: https://doi.org/10.1007/978-3-030-12438-0_6

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