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How Prevalent Is Cancer in Confirmed Cases with Coronaviruses and Severe Acute Respiratory Syndromes?

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Coronavirus Disease - COVID-19

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1318))

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Abstract

Novel coronavirus disease 2019 (COVID-19) has posed a crucial hazard to global health. The new species share similarities with the two previously emerged entities: severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome (MERS) that have caused outbreaks in 2002 and 2012, respectively. Interestingly, all of these coronaviruses can cause potentially fatal respiratory syndromes, though behave differently in patients with cancer compared to patients without cancer. Accordingly, the present chapter aims to, through a systematic investigation, estimate the prevalence of cancer among COVID-19, SARS, and MERS confirmed cases. Our analysis based on data from 78 studies with SARS, MERS, and COVID-19 confirmed cases showed that the prevalence of cancer (4.94%) stands at fourth place after hypertension (20.8%), diabetes (11.39%), and cardiovascular diseases (7.46%). According to the findings of the present study, comorbidities are significantly more common in patients with MERS compared to patients with COVID-19 and SARS, and this was the cancer case as well. Further studies need to address whether or not patients with coronaviruses and cancer are different from patients with coronaviruses without cancer in terms of clinical manifestations, laboratory findings, outcomes, and men to women ratio.

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Authors and Affiliations

  1. Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran

    Maryam Fotouhi, Elham Samami, Sahar Mohseni, Amir Nasrollahizadeh, Mohammad Haddadi, Mona Mirbeyk & Amene Saghazadeh

  2. School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Maryam Fotouhi, Amir Nasrollahizadeh, Mohammad Haddadi & Mona Mirbeyk

  3. School of Medicine, Iran University of Medical Sciences, Tehran, Iran

    Elham Samami

  4. School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran

    Sahar Mohseni

  5. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

    Amene Saghazadeh & Nima Rezaei

  6. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Nima Rezaei

  7. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran University of Medical Sciences, Tehran, Iran

    Nima Rezaei

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  1. Maryam Fotouhi
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    Nima Rezaei

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Fotouhi, M. et al. (2021). How Prevalent Is Cancer in Confirmed Cases with Coronaviruses and Severe Acute Respiratory Syndromes?. In: Rezaei, N. (eds) Coronavirus Disease - COVID-19. Advances in Experimental Medicine and Biology, vol 1318. Springer, Cham. https://doi.org/10.1007/978-3-030-63761-3_17

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