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Coronavirus: Pure Infectious Disease or Genetic Predisposition

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Coronavirus Disease - COVID-19

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 1318))

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes novel coronavirus disease (COVID-19), is the seventh pathogenic coronavirus recently discovered in December 2019 in Wuhan, China. To date, our knowledge about its effect on the human host remains limited. It is well known that host genetic factors account for the individual differences in the susceptibility to infectious diseases. The genetic susceptibility factors to COVID-19 and its severity are associated with several unanswered questions. However, the experience gained from an earlier strain of coronavirus, SARS-CoV-1, which shows 78% genetic similarity to SARS-CoV-2 and uses the same receptor to bind to host cells, could provide some clues. It, therefore, seems possible to assemble new evidence in order to solve a potential genetic predisposition puzzle for COVID-19. In this chapter, the puzzle pieces, including virus entry receptors, immune response, and inflammation-related genes, as well as the probable genetic predisposition models to COVID-19, are discussed.

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Authors and Affiliations

  1. Department of Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Farzaneh Darbeheshti

  2. Medical Genetics Network (MeGeNe), Universal Scientific Education and Research Network (USERN), Tehran, Iran

    Farzaneh Darbeheshti & Sepideh Shahkarami

  3. Division of Clinical Immunology, Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital Huddinge, Stockholm, Sweden

    Hassan Abolhassani

  4. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran

    Hassan Abolhassani, Samaneh Zoghi & Nima Rezaei

  5. Primary Immunodeficiency Diseases Network (PIDNet), Universal Scientific Education and Research Network (USERN), Stockholm, Sweden

    Hassan Abolhassani

  6. Division of Gastroenterology, Department of Internal Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA

    Mohammad Bashashati

  7. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), El Paso, TX, USA

    Mohammad Bashashati

  8. Department of Human Anatomy and Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada

    Saeid Ghavami

  9. Faculty of Medicine, Katowice School of Technology, Katowice, Poland

    Saeid Ghavami

  10. Gene center, Ludwig-Maximilians-University of Munich, Munich, Germany

    Sepideh Shahkarami

  11. Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases, Vienna, Austria

    Samaneh Zoghi

  12. Department of Medicine, Division of Basic and Clinical Immunology, University of California, Irvine, CA, USA

    Sudhir Gupta

  13. Immunology, Allergy, and Rheumatology, Baylor College of Medicine and the Texas Children’s Hospital, Houston, TX, USA

    Jordan S. Orange

  14. School of Medicine, Department of Pediatrics, University of Washington, Seattle, WA, USA

    Hans D. Ochs

  15. Universal Scientific Education and Research Network (USERN), Seattle, WA, USA

    Hans D. Ochs

  16. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Nima Rezaei

  17. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

    Nima Rezaei

  18. Children’s Medical Center Hospital, Tehran, Iran

    Nima Rezaei

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  1. Farzaneh Darbeheshti
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  2. Hassan Abolhassani
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  3. Mohammad Bashashati
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  4. Saeid Ghavami
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  5. Sepideh Shahkarami
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  7. Sudhir Gupta
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  8. Jordan S. Orange
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  9. Hans D. Ochs
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  10. Nima Rezaei
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Correspondence to Nima Rezaei .

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  1. Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran

    Nima Rezaei

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Darbeheshti, F. et al. (2021). Coronavirus: Pure Infectious Disease or Genetic Predisposition. In: Rezaei, N. (eds) Coronavirus Disease - COVID-19. Advances in Experimental Medicine and Biology, vol 1318. Springer, Cham. https://doi.org/10.1007/978-3-030-63761-3_6

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