Abstract
Corneal collagen cross-linking (CXL) using the classical Dresden protocol has the potential to create complications, including endothelial cell damage, persistent epithelial defects, scarring, and infectious keratitis. Most of these complications are due to epithelial removal, which can be avoided by newer techniques that allow penetration of riboflavin through an intact epithelium.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Wollensak G, et al. Endothelial cell damage after riboflavin-ultraviolet-A treatment in the rabbit. J Cataract Refract Surg. 2003;29(9):1786–90.
Pollhammer M, Cursiefen C. Bacterial keratitis early after corneal crosslinking with riboflavin and ultraviolet-A. J Cataract Refract Surg. 2009;35(3):588–9.
Zamora KV, Males JJ. Polymicrobial keratitis after a collagen cross-linking procedure with postoperative use of a contact lens: a case report. Cornea. 2009;28(4):474–6.
Perez-Santonja JJ, et al. Microbial keratitis after corneal collagen crosslinking. J Cataract Refract Surg. 2009;35(6):1138–40.
Yuksel N, Bilgihan K, Hondur AM. Herpetic keratitis after corneal collagen cross-linking with riboflavin and ultraviolet-A for progressive keratoconus. Int Ophthalmol. 2011;31(6):513–5.
Kymionis GD, et al. Herpetic keratitis with iritis after corneal crosslinking with riboflavin and ultraviolet A for keratoconus. J Cataract Refract Surg. 2007;33(11):1982–4.
Rama P, et al. Acanthamoeba keratitis with perforation after corneal crosslinking and bandage contact lens use. J Cataract Refract Surg. 2009;35(4):788–91.
Abbouda A, Abicca I, Alio JL. Infectious keratitis following corneal crosslinking: a systematic review of reported cases: management, visual outcome, and treatment proposed. Semin Ophthalmol. 2014:1–7.
Ferrari G, et al. Impending corneal perforation after collagen cross-linking for herpetic keratitis. J Cataract Refract Surg. 2013;39(4):638–41.
Kymionis GD, Portaliou DM. Corneal collagen crosslinking and herpetic keratitis. J Cataract Refract Surg. 2013;39(8):1281.
Sharma A, et al. Persistent corneal edema after collagen cross-linking for keratoconus. Am J Ophthalmol. 2012;154(6):922–6.e1.
Bagga B, et al. Endothelial failure after collagen cross-linking with riboflavin and UV-A: case report with literature review. Cornea. 2012;31(10):1197–200.
Raiskup F, Spoerl E. Corneal cross-linking with hypo-osmolar riboflavin solution in thin keratoconic corneas. Am J Ophthalmol. 2011;152(1):28–32.e1.
Kymionis GD, et al. Corneal collagen cross-linking with riboflavin and ultraviolet-A irradiation in patients with thin corneas. Am J Ophthalmol. 2012;153(1):24–8.
Wollensak G, et al. Keratocyte apoptosis after corneal collagen cross-linking using riboflavin/UVA treatment. Cornea. 2004;23(1):43–9.
Messmer EM, et al. Morphological and immunohistochemical changes after corneal cross-linking. Cornea. 2013;32(2):111–7.
Richoz O, et al. The effect of standard and high-fluence corneal cross-linking (CXL) on cornea and limbus. Invest Ophthalmol Vis Sci. 2014;55(9):5783–7.
Elbaz U, et al. Collagen crosslinking after radial keratotomy. Cornea. 2014;33(2):131–6.
Abad JC, Vargas A. Gaping of radial and transverse corneal incisions occurring early after CXL. J Cataract Refract Surg. 2011;37(12):2214–7.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer International Publishing Switzerland
About this chapter
Cite this chapter
Stulting, R.D. (2017). Complications of Corneal Cross-linking. In: Sinjab, M., Cummings, A. (eds) Corneal Collagen Cross Linking. Springer, Cham. https://doi.org/10.1007/978-3-319-39775-7_7
Download citation
DOI: https://doi.org/10.1007/978-3-319-39775-7_7
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-39773-3
Online ISBN: 978-3-319-39775-7
eBook Packages: MedicineMedicine (R0)