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Porphyrin and Phthalocyanine Radiolabeling

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Radionanomedicine

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

Abstract

There have been substantial improvements in radiopharmaceutical chemistry with respect to designing new diagnostic and therapeutic agents for combatting diseases. Porphyrin and phthalocyanine derivatives have been explored in this field because they possess unique photophysical properties, can accumulate in human and animal tumors, and their metal complexes are both thermodynamically and kinetically stable. A wide variety of radiolabeled metalloporphyrins and metallo phthalocyanines can be prepared that are stable in biological media. Radiolabeled compounds have been employed in preclinical applications for nuclear imaging, biodistribution studies, and photodynamic therapy. This chapter provides an overview of radiopharmaceutical applications of porphyins and phthalocyanines including small molecule and nanoparticle-based approaches.

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Authors and Affiliations

  1. Department of Biomedical Engineering, University at Buffalo, State University of New York, Buffalo, NY, 14260, USA

    Venugopal Rajendiran, Sanjana Ghosh & Jonathan F. Lovell

  2. Department of Chemistry, School of Basic and Applied Sciences, Central University of Tamil Nadu, Thiruvarur, 610005, India

    Venugopal Rajendiran

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  1. Department of Nuclear Medicine, Seoul National University, Seoul, Korea (Republic of)

    Dong Soo Lee

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Rajendiran, V., Ghosh, S., Lovell, J.F. (2018). Porphyrin and Phthalocyanine Radiolabeling. In: Lee, D. (eds) Radionanomedicine. Biological and Medical Physics, Biomedical Engineering. Springer, Cham. https://doi.org/10.1007/978-3-319-67720-0_3

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