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Genetische Aspekte mikroassistierter Reproduktion

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Genetik von Krankheiten des Urogenitalsystems

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Zusammenfassung

Auf dem Gebiet der in vitro-Fertilisierung und im direkten Umgang mit menschlichen Keimzellen waren in den vergangenen Jahren enorme Fortschritte zu verzeichnen. Nach der subzonalen Insemination (SUZI) stellt die intrazytoplasmatische Spermieninjektion (ICSI), also die Injektion eines einzelnen Spermiums in die Eizelle, das invasivste Verfahren dar. Diese Verfahren erhöhen deutlich die Chance, den Kinderwunsch von Paaren mit ungewollter Kinderlosigkeit, bei denen weniger invasive Verfahren der Reproduktionsmedizin, wie in vitro-Fertilisierung (IVF) und intratubarer Gameten- (GIFT) oder Zygoten- (ZIFT) Transfer u.a. versagen, zu erfüllen. Bisher werden, bei denen die Fertilitätsstörung andrologisch beding ist, bzw. bei denen trotz morphologisch und funktionell normaler Spermien die Befruchtung der Eizelle ausbleibt oder eine Störung auf der Ebene der Zona pellucida angenommen werden kann.

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Authors
  1. B. Wullich
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  2. K. Zang
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Editors and Affiliations

  1. Klinik und Poliklinik für Urologie und Kinderurologie, der Universität des Saarlandes, 66421, Homburg/Saar, Deutschland

    Bernd Wullich Priv. Doz. Dr. med.

  2. Leiter des Instituts für Humangenetik, der Universität des Saarlandes, 66421, Homburg/Saar, Deutschland

    Klaus Dieter Zang Prof. Dr. med.

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© 2000 Springer-Verlag Berlin Heidelberg

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Wullich, B., Zang, K. (2000). Genetische Aspekte mikroassistierter Reproduktion. In: Wullich, B., Zang, K.D. (eds) Genetik von Krankheiten des Urogenitalsystems. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59589-9_13

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  • DOI: https://doi.org/10.1007/978-3-642-59589-9_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64039-1

  • Online ISBN: 978-3-642-59589-9

  • eBook Packages: Springer Book Archive

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