Abstract
Amniocentesis (AC) is by far the most often used invasive prenatal diagnostic procedure. Amniotic fluid cells were first used for prenatal diagnosis by Fuchs and Philipp (1963) for sex chromatin determination in a pregnancy at risk for an X-linked disease. After successful establishing of amniotic fluid cell culture techniques by Steele and Breg (1966), 2 years later the first prenatal diagnoses of a chromosome aberration ie trisomy 21 (Valenti et al. 1968), and of a metabolic disorder ie galactosaemia (Nadler 1968) were reported.
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© 1999 Springer-Verlag Berlin Heidelberg
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Kennerknecht, I., Djalali, M., Barbi, G., Just, W., Vogel, W. (1999). Amniotic Fluid Cell Analysis. In: Wegner, RD. (eds) Diagnostic Cytogenetics. Springer Lab Manual. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59918-7_12
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DOI: https://doi.org/10.1007/978-3-642-59918-7_12
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