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Maligne Melanome in Kindheit und Jugend

  • Conference paper
Operative onkologische Dermatologie

Part of the book series: Fortschritte der operativen und onkologischen Dermatologie ((OP.DERMATOLOGIE,volume 15))

  • 51 Accesses

Zusammenfassung

Die in den letzten Jahren beobachtete weltweite deutliche Zunahme der malignen Melanome betrifft vor allem Erwachsene. Der Gipfel der Erkrankungshäufigkeit liegt zwischen dem 40. und 60. Lebensjahr. Als eine wahrscheinliche Ursache dafür wird die im Vergleich zu früheren Generationen viel stärkere UV-Exposition der jetzt Erwachsenen in der Kindheit und Jugend diskutiert [11]. In einigen Staaten scheint sich die Inzidenz allerdings zu stabilisieren [21]. In der Kindheit selbst können sich während dieser Altersphase solche tumorinduzierenden Faktoren naturgemäß noch kaum auswirken. Die Tumorentwicklung erfordert Zeit [28]. Dementsprechend treten maligne Melanome auch heute unterhalb des 20. Lebensjahres selten auf, sie machen ungefähr 1–3% aller Tumoren im Kindesalter und nur ungefähr 1% aller malignen Melanome aus. Nach dem Schrifttum hat ihre Inzidenz nicht zugenommen [3, 44].

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Literatur

  1. Alper JC (1985) Congenital nevi: The controversy rages on. Arch Dermatol 121: 734–735.

    Article  PubMed  CAS  Google Scholar 

  2. Bahmer FA (1986) Measurement and figure in dermatology. Arch Dermatol 122: 501.

    Article  PubMed  CAS  Google Scholar 

  3. Berg P, Lindelöf B (1997) Differences in malignant melanoma between children and adolescents. Arch Dermatol 133: 295–297.

    Article  PubMed  CAS  Google Scholar 

  4. Boddie AW Jr, Smith JL, McBride CM (1978) Malignant melanoma in children and young adults: effect of diagnostic criteria on staging and results. South med J 71: 1074–1078.

    Article  PubMed  Google Scholar 

  5. Castilla EE, Dutra MDG, Orioli-Parreiras IM (1981) Epidemiology of congenital pigmented naevi: I. Incidence rates and relative frequencies. Br J Dermatol 104: 307–315.

    Article  PubMed  CAS  Google Scholar 

  6. Davidoff AM, Cirrincione C, Hilliard F, Seigier F (1994) Malignant melanoma in children. Ann Surg Oncol 1: 278–282.

    Article  PubMed  CAS  Google Scholar 

  7. Elder DE (1985) The blind men and the elephant: Different views of small congenital nevi. Arch Dermatol 121: 263–265.

    Article  Google Scholar 

  8. English JSC, Swerdlow AJ (1987) The risk of malignant melanoma, internal malignancy and mortality in xeroderma pigmentosum patients. Br J Dermatol 117: 457–461.

    Article  PubMed  CAS  Google Scholar 

  9. Fish J, Smith EB, Canby JP (1966) Malignant melanoma in childhood. Surgery 59: 309–315.

    PubMed  CAS  Google Scholar 

  10. Gallagher RP, McLean DI, Yang CP, Coldman AJ, Silver HKB, Spinelli JJ, Beagrie M (1990) Anatomic distribution of acquired melanocytic nevi in white children. A com-parison with melanoma: The Vancouver mole study. Arch Dermatol 125: 466–471.

    Google Scholar 

  11. Garbe C (1992) Sonne und malignes Melanom. Hautarzt 43: 251–257.

    PubMed  CAS  Google Scholar 

  12. Gari LM, Rivers JK, Kopf AW (1988) Melanomas arising in large congenital nevocytic nevi: A prospective study. Pediatr Dermatol 5: 151–158.

    Article  PubMed  CAS  Google Scholar 

  13. Goldstein AM, Fräser MC, Clark WH, Tucker MA (1994) Age at diagnosis and transmission of invasive melanoma in 23 Families with cutaneous malignant melanoma/ dysplastic nevi. J Natl Cancer Inst 86: 1385–1390.

    Article  PubMed  CAS  Google Scholar 

  14. Greeley PW (1965) Incidence of malignancy in giant pigmented naevi. Plast Reconstr Surg 36: 26–37.

    Article  PubMed  CAS  Google Scholar 

  15. Greene MH, Clark WH Jr, Tucker MA, Kraemer KH, Elder DE, Fräser MC (1985) High risk of malignant melanoma in melanoma-prone families with dysplastic nevi. Ann Intern Med 102: 458–465.

    PubMed  CAS  Google Scholar 

  16. Halpern AC, Du Pont Guerry IV, Eider DE, Clark WH, Synnestvedt M, Norman S, Ayerle R (1991) Dysplastic nevi as risk markers of sporadic (nonfamilial) melanoma. Arch Dermatol 127: 995–999.

    Article  PubMed  CAS  Google Scholar 

  17. Holly EA, Kelly JW, Shpall SN, Chiù SH (1987) Number of melanocytic nevi as a major risk factor for malignant melanoma. J Am Acad Dermatol 17: 459–468.

    Article  PubMed  CAS  Google Scholar 

  18. Hundeiker M (1987) Diagnose und Therapie der kongenitalen Pigmentzellnaevi. Dtsch med Wschr 112: 807–809.

    Article  PubMed  CAS  Google Scholar 

  19. Illig L, Weidner F, Hundeiker M, Gartmann H, Biess B, Leyh F, Paul E (1985) Congenital Nevi 10 cm as precursors to melanoma: 52 cases, a review, and a new conception. Arch Dermatol 121: 1274–1281.

    Article  PubMed  CAS  Google Scholar 

  20. Kaplan EN (1974) The risk of malignancy in large congenital naevi. Plast Reconstr Surg 53: 421–428.

    Article  PubMed  CAS  Google Scholar 

  21. Katsambas A, Nicolaidou E (1996) Cutaneous malignant melanoma and sun exposure. Recent developments in epidemilogy. Arch Dermatol 132 (4): 444–450.

    CAS  Google Scholar 

  22. Keipert JA (1985) Giant pigmented naevus: the frequency of malignant change and indications for treatment in prepubertal children. Aust J Dermatol 26: 81–85.

    Article  CAS  Google Scholar 

  23. Konz B (1980) Melanome im Kindesalter. Dermatologia 161: 62–73.

    Article  Google Scholar 

  24. Kopf AW, Bart RS, Hennessey P (1979) Congenital nevocytic nevi and malignant melanomas. J Am Acad Dermatol 1: 123–130.

    Article  PubMed  CAS  Google Scholar 

  25. Kraemer KH, Greene MH, Tarone R, Elder DE, Clark WH Jr, Guerry DN (1983) Dysplastic naevi and cutaneous melanoma risk. Lancet 2: 1076–1077.

    Article  PubMed  CAS  Google Scholar 

  26. Kraemer KH, Lee MM, Scotto J (1987) Xeroderma pigmentosum: cutaneous, ocular, and neurologic abnormalities in 830 published cases. Arch Dermatol 123: 241–250.

    Article  PubMed  CAS  Google Scholar 

  27. Lartigau E, Spatz A, Avril MF, Bailly C, Lemerle J, Terrier-Lacombe MJ, Margulis A, Prade M (1995) Melanoma arising de novo in childhood: experience of the Gustave-Roussy-Institute. Melanoma Res 5: 177–122.

    Article  Google Scholar 

  28. Lippold A, Hundeiker M (1991) Alter und Tumordicke bei Melanompatienten. Z. Hautkr. 66 (7): 639–640.

    Google Scholar 

  29. MacKie RM, Watt D, Doherty V, Aitchison T (1991) Malignant melanoma occuring in those aged under 30 in the west of Scotland 1979–1986: a study of incidence, clinical features, pathological features and survival. Br J Dermatol 124: 560–564.

    Article  PubMed  CAS  Google Scholar 

  30. Melnik MK, Urdaneta LF, Al-Jurf AS, Foucar E, Jochimsen PR, Soper RT (1986) Malignant melanoma in childhood and adolescence. Am Surg 52: 142–147.

    PubMed  CAS  Google Scholar 

  31. Moss ALH, Briggs JC (1986) Cutaneous malignant melanoma in the young. Br J Plast Surg 39: 537–541.

    Article  PubMed  CAS  Google Scholar 

  32. Müller RPA, Hundeiker M (1991) Congenitale Pigmentzellnaevi-Therapiekonzepte. In: Meigel W (Hrsg.): Diagnostik und Therapie maligner Melanome. Diesbach Verlag, Berlin S 21–29.

    Google Scholar 

  33. Naasan A, Al-Nafussi, A, Quaba A (1996): Cutaneous malignant melanoma in children and adolescents in Scotland, 1979–1991. Plast Reconstr Surg 98: 442–446.

    Article  PubMed  CAS  Google Scholar 

  34. Novakovic B, Clark WH Jr, Fears TR, Fraser MC, Tucker MA (1995) Melanocytic nevi, dysplastic nevi, and malignant melanoma in children from melanoma-prone families. J Am Acad Dermatol 33 (4): 631–636.

    Article  PubMed  CAS  Google Scholar 

  35. Pers M (1963) Neavus pigmentosus giganticus: Indikationer for operative behandling. Ungeskr Laeger 125: 613–619.

    Google Scholar 

  36. Potter JF, Schoeneman M (1960): Metastasis of maternal cancer to the placenta and fetus. Cancer 25: 392–397.

    Google Scholar 

  37. Quaba AA, Wallace AE 1986) The incidence of malignant melanoma (0 to 15 years of age) arising in “large” congenital nevocellular nevi. Plast Reconstr Surg 78: 174–179.

    Article  PubMed  CAS  Google Scholar 

  38. Rampen FHJ, van der Meeren HLM, Boezeman JBM (1986) Frequency of moles as a key to melanoma incidence? J Am Acad Dermatol 15: 1200–1203.

    Article  PubMed  CAS  Google Scholar 

  39. Rao BN, Hayes FA, Pratt CB, Fleming ID, Kumar APM, Lobe T, Dilawari R, Meyer W, Parham D, Custer MD (1990): Malignant melanoma in children: its management and prognosis. J Pediatr Surg 25 (2): 198–203.

    Article  PubMed  CAS  Google Scholar 

  40. Reed WB, Becker SW Sr, Becker SW Jr, Nickel WR (1965) Giant pigmented naevi, melanoma, and leptomenigeal melanocytosis. Arch Dermatol 91: 100–119.

    Article  PubMed  CAS  Google Scholar 

  41. Reintgen DS, Vollmer R, Seigier HF (1989) Juvenile malignant melanoma. Surg Gynecol Obstet 168: 249–253.

    PubMed  CAS  Google Scholar 

  42. Rhodes AR (1986) Melanocytic precursors of cutaneous melanoma. Estimated risks and guidelines for management. Med Clin North Am 70: 3–37.

    CAS  Google Scholar 

  43. Rhodes AR, Sober AJ, Day CL, Meiski JW, Harrist TJ, Mihm MC, Fitzpatrick TB (1982): The malignant potential of small congenital nevocellular nevi: an estimate of association based on a histological study of 234 primary coutaneous melanomas. J Am Acad Dermatol 6: 230–241.

    Article  PubMed  CAS  Google Scholar 

  44. Ruiz-Maldonado R, Orozco-Covarrubias M (1997): Malignant melanoma in children. Arch Dermatol 133: 363–371.

    Article  PubMed  CAS  Google Scholar 

  45. Spatz A, Ruiter D, Hardmeier T, Renard N, Wechsler J, Bailly C, Avril MF, Kwee H, Bastian BC, Hill C, De Potter C, Prade M (1996): Melanoma in childhood: an EORTC-MCG multicenter study on the clinico-pathological aspects. Int J Cancer 68 (3): 317–324.

    Article  PubMed  CAS  Google Scholar 

  46. Swerdlow AJ, English J, MacKie RM (1986) Benign melanocytic moles as a risk factor for malignant melanoma. Br Med J 292: 1555–1559.

    Article  CAS  Google Scholar 

  47. Tate PS, Ronan SG, Feucht KA, Eng AM, Das Gupta TK (1993) Melanoma in childhood and adolescence: clinical and pathological features of 48 cases. J Pediatr Surg 28: 217–222.

    Article  PubMed  CAS  Google Scholar 

  48. The management of congenital nevocytic nevi [Symposium] (1984) Pediatr Dermatol 2: 143–156.

    Google Scholar 

  49. Tucker MA, Crutcher WA, Hartge P, Sagebiel RW (1993) Familial and cutaneous features of dysplastic nevi: a case-control study. J Am Acad Dermatol 28: 558–564.

    Article  PubMed  CAS  Google Scholar 

  50. Walton RG, Jacobs AH, Cox AJ (1976) Pigmented lesions in newborn infants. Br J Dermatol 95: 389–396.

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. A. Jansen
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  2. M. Hundeiker
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Editors and Affiliations

  1. Hautklinik, Städtische Kliniken Kassel, Mönchebergstraße 41–43, D-34125, Kassel, Germany

    Rainer Rompel  & Johannes Petres  & 

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© 1999 Springer-Verlag Berlin Heidelberg

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Jansen, A., Hundeiker, M. (1999). Maligne Melanome in Kindheit und Jugend. In: Rompel, R., Petres, J. (eds) Operative onkologische Dermatologie. Fortschritte der operativen und onkologischen Dermatologie, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60048-7_8

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  • DOI: https://doi.org/10.1007/978-3-642-60048-7_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64233-3

  • Online ISBN: 978-3-642-60048-7

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