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Tachykinins: Central and Peripheral Effects

  • Chapter
The Pharmacology of Pain

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 130))

Abstract

The neurobiology of tachykinins and tachykinin receptors has been studied for several decades (Guard and Watson 1991; Nakanishi 1991). The tachykinins are a family of peptides that are broadly distributed in the mammalian central nervous system. This neuropeptide family includes substance P (SP), neurokinin A and neurokinin B, and these act preferentially on three major neurokinin receptors, NK-1, NK-2 and NK-3, respectively (Patacchini and Maggi 1995). Substance P and NK-1 receptors represent the most extensively studied sensory neuropeptide system, and this chapter reviews the central and peripheral effects of this tachykinin and discusses the therapeutic potential of drugs designed to interact specifically with this system.

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Authors
  1. P. J. Birch
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Editors and Affiliations

  1. Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK

    A. Dickenson

  2. Physiopharmacologie du Système Nerveux et Laboratioire de Physiopharmacologie de la Douluer (EPHE), INSERM, U.161, 2, rue d’Alésia, F-75014, Paris, France

    J.-M. Besson

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© 1997 Springer-Verlag Berlin Heidelberg

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Birch, P.J. (1997). Tachykinins: Central and Peripheral Effects. In: Dickenson, A., Besson, JM. (eds) The Pharmacology of Pain. Handbook of Experimental Pharmacology, vol 130. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60777-6_6

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  • DOI: https://doi.org/10.1007/978-3-642-60777-6_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64550-1

  • Online ISBN: 978-3-642-60777-6

  • eBook Packages: Springer Book Archive

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