Abstract
Hepatic artery infusion (HAI) with floxuridine (FUDR) has resulted in CT-confirmed remission rates between 30% and 50% in patients with liver metastases from colorectal cancer [5]. In spite of very optimistic reports, especially that by Balch and Urist [1], long-term results are less impressive. There is a relatively high risk of local toxicity due to chemical hepatitis and/or sclerosing cholangitis [3]. A high proportion of the patients will eventually develop extrahepatic metastases, and no statistically significant survival advantage for patients treated by HAI with FUDR has yet been demonstrated [4,6].
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Balch CM, Urist MM (1984) Intraarterielle Chemotherapie mit einer implantierbaren Infusionspumpe bei Lebermetastasen colorectaler Tumoren und Hepatomen. Chirung 55: 485–493
Ensminger WD, Gyves J (1983) Clinical pharmacology of hepatic arterial chemotherapy. Semin Oncol 10:1876–1882
Hohn D, Rayner AA, Economou JS, Ignoffo RJ, Lewis BJ, Stagg RJ (1986) Toxicities and complications of implanted pump hepatic arterial and intravenous floxuridine infusion. Cancer 57:465–470
Hohn D, Stagg R, Friedman M, Ignoffo R, Rayner A, Hannigan J, Lewis B (1987) The NCOG randomized trial of intravenous versus hepatic arterial FUDR for colorectal cancer metastatic to the liver. ASCO Proc 6(333):85
Kemeny N, Daly J, Oderman P, Shike M, Chun H, Petroni G, Geller N (1984) Hepatic artery pump infusion: toxicity and results in patients with metastatic colorectal carcinoma. J Clin Oncol 2:595–600
Kemeny N, Daly J, Reichman B, Geller N, Botet J, Oderman P (1987) Intrahepatic or systemic infusion of fluorodeoxyuridine in patients with liver metastases from colorectal carcinoma. Ann Intern Med 107:459–465
Peyerl G (1986) Pharmakokinetik von 5-Fluorouracil bei der isolierten Leberperfusion und sein chromatographischer Nachweis im Serum. Dissertation, München
Schalhorn A, Peyerl G, Denecke H (1988) Pharmacokinetics of 5-fluorouracil during isolated liver perfusion. Reg Cancer Treat 1:21–27
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Schalhorn, A., Peyerl, G., Heinlein, W., Wilmanns, W. (1990). Regional Therapy with 5-Fluorouracil: Dependence of Systemic Concentrations on the Infusion Rate. In: Jakesz, R., Rainer, H. (eds) Progress in Regional Cancer Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74818-9_12
Download citation
DOI: https://doi.org/10.1007/978-3-642-74818-9_12
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-74820-2
Online ISBN: 978-3-642-74818-9
eBook Packages: Springer Book Archive