Abstract
Hepatic artery infusion (HAI) with floxuridine (FUDR) has resulted in CT-confirmed remission rates between 30% and 50% in patients with liver metastases from colorectal cancer [5]. In spite of very optimistic reports, especially that by Balch and Urist [1], long-term results are less impressive. There is a relatively high risk of local toxicity due to chemical hepatitis and/or sclerosing cholangitis [3]. A high proportion of the patients will eventually develop extrahepatic metastases, and no statistically significant survival advantage for patients treated by HAI with FUDR has yet been demonstrated [4,6].
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References
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© 1990 Springer-Verlag Berlin Heidelberg
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Schalhorn, A., Peyerl, G., Heinlein, W., Wilmanns, W. (1990). Regional Therapy with 5-Fluorouracil: Dependence of Systemic Concentrations on the Infusion Rate. In: Jakesz, R., Rainer, H. (eds) Progress in Regional Cancer Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74818-9_12
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DOI: https://doi.org/10.1007/978-3-642-74818-9_12
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